Institution
Queen's University Belfast
Education•Belfast, United Kingdom•
About: Queen's University Belfast is a education organization based out in Belfast, United Kingdom. It is known for research contribution in the topics: Population & Context (language use). The organization has 25457 authors who have published 55463 publications receiving 1751346 citations. The organization is also known as: Queen's College, Belfast & Queen's College.
Topics: Population, Context (language use), Laser, Catalysis, Ionic liquid
Papers published on a yearly basis
Papers
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University College London1, Oregon Health & Science University2, Harvard University3, Lund University4, Vita-Salute San Raffaele University5, University of Manchester6, University of British Columbia7, Monash University8, The Royal Marsden NHS Foundation Trust9, Columbia University10, University of Texas MD Anderson Cancer Center11, University of California, Davis12, University of Bologna13, University of California, San Francisco14, Institut Gustave Roussy15, Duke University16, University of Cologne17, Medical University of Vienna18, University of Oslo19, Fred Hutchinson Cancer Research Center20, University of Washington21, University of Melbourne22, Peter MacCallum Cancer Centre23, Northwestern University24, Memorial Sloan Kettering Cancer Center25, Cornell University26, American University of Beirut27, Tel Aviv University28, National and Kapodistrian University of Athens29, Tata Memorial Hospital30, Icahn School of Medicine at Mount Sinai31, Ghent University32, Queen's University Belfast33, Belfast City Hospital34, The Chinese University of Hong Kong35, University of California, Los Angeles36, University of Bern37, University of Minnesota38, Université de Montréal39, Tulane University40, Prostate Cancer Foundation41, University of Hamburg42, Toho University43, Université catholique de Louvain44, Radboud University Nijmegen45, University of St. Gallen46
TL;DR: These voting results from a panel of prostate cancer experts can help clinicians and patients navigate controversial areas of advanced prostate management for which high-level evidence is sparse and provide a practical guide to help clinicians discuss therapeutic options with patients.
255 citations
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TL;DR: The informed decision to administer or not and the control of bleaching effects should stand in the hand of dental surgeons and certainly not as it appears at present, as cosmetics sold without any restriction despite the potential health hazards of peroxides.
Abstract: Hydrogen peroxide (H2O2) is a powerful oxidising agent. It gives rise to agents known to be effective bleaching agents. The mechanisms of bleaching involve the degradation of the extracellular matrix and oxidation of chromophores located within enamel and dentin. However, H2O2 produces also local undesirable effects on tooth structures and oral mucosa. In clinical conditions, the daily low-level doses used to produce tooth whitening never generate general acute and sub-acute toxic effects. Genotoxicity and carcinogenicity only occur at concentrations that are never reached during dental treatments. Some transient adverse effects have been reported on the oral mucosa and the digestive tract if the product is swallowed. Local effects may occur on the oral mucosa and dental tissues during whitening, namely, pulp sensitivity, cervical resorption, release of selected components of dental restorative materials, and alteration of the enamel surface. Most of the local effects are dependent of the technique and concentration of the product so far used, but as the results of bleaching obtained are not stable, repeated treatments add to the adverse effects. The informed decision to administer or not and the control of bleaching effects should stand in the hand of dental surgeons and certainly not as it appears at present, as cosmetics sold without any restriction despite the potential health hazards of peroxides.
255 citations
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TL;DR: Findings confirm the importance of two genetic factors associated with long-term antipsychotic-induced weight increases in schizophrenia, and implicate a role for leptin in the 5-HT receptor-mediated weight regulation.
Abstract: ObjectivesWeight gain, leading to further morbidity and poor treatment adherence, is a common consequence of treatment with antipsychotic drugs. Two recent studies in the same cohort of Chinese Han subjects have shown that polymorphisms of the promoter regions of both the serotonin 5-hydroxytryptami
255 citations
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01 Dec 1996TL;DR: This paper presents geological evidence for orbital-forcing of climatic oscillations, a proxy for biological response to climate change, and its implications for evolution and ecology.
Abstract: The mechanisms of macroevolutionary change have long been a contentious issue. Palaeoecological evidence, presented in this book, shows that evolutionary processes visible in ecological time do not build up into macroevolutionary trends, contrary to Darwin's original thesis. The author discusses how climatic oscillations on ice-age time-scales are paced by variations in the Earth's orbit, and have thus been a permanent feature of Earth history. There is, however, little evidence for macroevolutionary change in response to these climatic changes, suggesting that over geological time macroevolution does not occur as a result of accumulated short term processes. These conclusions are used to construct a post-modern evolutionary synthesis in which evolution and ecology play an equal role. Written by a leading palaeoecologist, this book will be of interest to researchers in both ecology and evolutionary biology.
255 citations
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TL;DR: The aim of this study was to determine sperm nuclear DNA integrity and mitochondrial function, to quantify possible apoptosis and to investigate any relationship between these parameters.
Abstract: Sperm DNA integrity is essential for accurate transmission of genetic material to offspring. Fragmentation of genomic DNA is an initial hallmark of apoptosis (programmed cell death). The aim of this study was to determine sperm nuclear DNA integrity and mitochondrial function, to quantify possible apoptosis and to investigate any relationship between these parameters. Semen samples (n = 25) were prepared by discontinuous Percoll density centrifugation (95.0:47.5). DNA integrity was determined using a modified alkaline single cell gel electrophoresis (Comet) assay. DNA fragmentation, possibly indicative of apoptosis, was detected by terminal deoxynucleotidyl transferase-mediated dUTP nick end labelling (TUNEL). Mitochondrial transmembrane potential was determined using the mitochondrial probe 5,5',6,6'-tetrachloro-1,1', 3,3'-tetraethylbenzimidazolyl carbocyanine iodide (JC-1). The DNA integrity of prepared spermatozoa was significantly greater than that of semen (P < 0.005). Further, the percentage of spermatozoa with fragmented DNA and the degree of fragmentation within these cells in prepared spermatozoa is significantly less than in semen (P < 0.005). There is a significant correlation between DNA damage quantified using the Comet assay and DNA fragmentation determined using TUNEL (R = 0.562, P < 0.01). The percentage of spermatozoa with dysfunctional, possibly apoptotic, mitochondria was significantly lower in prepared spermatozoa than in neat semen samples (P < 0.001). There was a negative correlation between the percentage of spermatozoa with dysfunctional mitochondria and the percentage of progressively motile spermatozoa (R = -0.67, P < 0.01).
254 citations
Authors
Showing all 25808 results
Name | H-index | Papers | Citations |
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George Davey Smith | 224 | 2540 | 248373 |
David J. Hunter | 213 | 1836 | 207050 |
Grant W. Montgomery | 157 | 926 | 108118 |
Caroline S. Fox | 155 | 599 | 138951 |
Debbie A Lawlor | 147 | 1114 | 101123 |
Markus Ackermann | 146 | 610 | 71071 |
Hermann Kolanoski | 145 | 1279 | 96152 |
Paul Jackson | 141 | 1372 | 93464 |
Alan Ashworth | 134 | 578 | 72089 |
Conor Henderson | 133 | 1387 | 88725 |
David Smith | 129 | 2184 | 100917 |
Stuart J. Connolly | 125 | 610 | 75925 |
G. Merino | 123 | 687 | 66163 |
Richard J.H. Smith | 118 | 1308 | 61779 |
Yong-Guan Zhu | 115 | 684 | 46973 |