Institution
Queen's University Belfast
Education•Belfast, United Kingdom•
About: Queen's University Belfast is a education organization based out in Belfast, United Kingdom. It is known for research contribution in the topics: Population & Context (language use). The organization has 25457 authors who have published 55463 publications receiving 1751346 citations. The organization is also known as: Queen's College, Belfast & Queen's College.
Topics: Population, Context (language use), Laser, Catalysis, Ionic liquid
Papers published on a yearly basis
Papers
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TL;DR: The proposed basic clinical classification scale seems to be of value in predicting the risk of late AMD, and incorporating consistent nomenclature into the practice patterns of all eye care providers may improve communication and patient care.
1,114 citations
Harvard University1, Broad Institute2, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico3, McMaster University4, McGill University5, University of Leicester6, University of Lübeck7, University of Pennsylvania8, Vanderbilt University9, University of Missouri–Kansas City10, University of Münster11, University of Verona12, Queen's University Belfast13, University of Washington14, Boston University15, University of Helsinki16, National Institute for Health and Welfare17, Lund University18, University of Cambridge19, Vita-Salute San Raffaele University20, University of Ferrara21, University of Turin22, Hebrew University of Jerusalem23, University of Girona24, University of Milan25, University of Leeds26, University of Regensburg27, Ludwig Maximilian University of Munich28, University of Kiel29, Wellcome Trust Sanger Institute30, University of Paris31, MedStar Washington Hospital Center32, deCODE genetics33, University of Iceland34
TL;DR: SNPs at nine loci were reproducibly associated with myocardial infarction, but tests of common and rare CNVs failed to identify additional associations with my Cardiovascular Infarction risk.
Abstract: We conducted a genome-wide association study testing single nucleotide polymorphisms (SNPs) and copy number variants (CNVs) for association with early-onset myocardial infarction in 2,967 cases and 3,075 controls We carried out replication in an independent sample with an effective sample size of up to 19,492 SNPs at nine loci reached genome-wide significance: three are newly identified (21q22 near MRPS6-SLC5A3-KCNE2, 6p24 in PHACTR1 and 2q33 in WDR12) and six replicated prior observations1, 2, 3, 4 (9p21, 1p13 near CELSR2-PSRC1-SORT1, 10q11 near CXCL12, 1q41 in MIA3, 19p13 near LDLR and 1p32 near PCSK9) We tested 554 common copy number polymorphisms (>1% allele frequency) and none met the pre-specified threshold for replication (P < 10-3) We identified 8,065 rare CNVs but did not detect a greater CNV burden in cases compared to controls, in genes compared to the genome as a whole, or at any individual locus SNPs at nine loci were reproducibly associated with myocardial infarction, but tests of common and rare CNVs failed to identify additional associations with myocardial infarction risk
1,092 citations
Lars G. Fritsche1, Wilmar Igl2, Jessica N. Cooke Bailey3, Felix Grassmann2 +182 more•Institutions (58)
TL;DR: The results support the hypothesis that rare coding variants can pinpoint causal genes within known genetic loci and illustrate that applying the approach systematically to detect new loci requires extremely large sample sizes.
Abstract: Advanced age-related macular degeneration (AMD) is the leading cause of blindness in the elderly, with limited therapeutic options. Here we report on a study of >12 million variants, including 163,714 directly genotyped, mostly rare, protein-altering variants. Analyzing 16,144 patients and 17,832 controls, we identify 52 independently associated common and rare variants (P < 5 × 10(-8)) distributed across 34 loci. Although wet and dry AMD subtypes exhibit predominantly shared genetics, we identify the first genetic association signal specific to wet AMD, near MMP9 (difference P value = 4.1 × 10(-10)). Very rare coding variants (frequency <0.1%) in CFH, CFI and TIMP3 suggest causal roles for these genes, as does a splice variant in SLC16A8. Our results support the hypothesis that rare coding variants can pinpoint causal genes within known genetic loci and illustrate that applying the approach systematically to detect new loci requires extremely large sample sizes.
1,088 citations
University of Minnesota1, University of Michigan2, Florida State University3, University of Twente4, Queen's University Belfast5, University of California, Berkeley6, University of Belgrade7, University of Bristol8, University of Padua9, University of York10, Osaka University11, Loughborough University12, Leibniz Association13, Brno University of Technology14, Academy of Sciences of the Czech Republic15, Comenius University in Bratislava16, École Polytechnique17, Ulster University18, Clarkson University19, Michigan Technological University20, University of Antwerp21, Lublin University of Technology22, University of Montpellier23, Eindhoven University of Technology24, Max Planck Society25, University of Alberta26, Durham University27, Lawrence Berkeley National Laboratory28, National Institute of Advanced Industrial Science and Technology29, Saint Petersburg State University30
TL;DR: A review of the state-of-the-art of this multidisciplinary area and identifying the key research challenges is provided in this paper, where the developments in diagnostics, modeling and further extensions of cross section and reaction rate databases are discussed.
Abstract: Plasma–liquid interactions represent a growing interdisciplinary area of research involving plasma science, fluid dynamics, heat and mass transfer, photolysis, multiphase chemistry and aerosol science. This review provides an assessment of the state-of-the-art of this multidisciplinary area and identifies the key research challenges. The developments in diagnostics, modeling and further extensions of cross section and reaction rate databases that are necessary to address these challenges are discussed. The review focusses on non-equilibrium plasmas.
1,078 citations
TL;DR: A receptor is described that operates as a logic device with two input channels: the fluorescence signal depends on whether the molecule binds hydrogen ions, sodium ions or both and the input/output characteristics of this molecular device correspond to those of an AND gate.
Abstract: MOLECULES that perform logic operations are prerequisites for molecular information processing and computation1–11. We12,13 and others14–16 have previously reported receptor molecules that can be considered to perform simple logic operations by coupling ionic bonding or more complex molecular-recognition processes with photonic (fluorescence) signals: in these systems, chemical binding (the 'input') results in a change in fluorescence intensity (the 'output') from the receptor. Here we describe a receptor (molecule (1) in Fig. 1) that operates as a logic device with two input channels: the fluorescence signal depends on whether the molecule binds hydrogen ions, sodium ions or both. The input/output characteristics of this molecular device correspond to those of an AND gate.
1,059 citations
Authors
Showing all 25808 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| George Davey Smith | 224 | 2540 | 248373 |
| David J. Hunter | 213 | 1836 | 207050 |
| Grant W. Montgomery | 157 | 926 | 108118 |
| Caroline S. Fox | 155 | 599 | 138951 |
| Debbie A Lawlor | 147 | 1114 | 101123 |
| Markus Ackermann | 146 | 610 | 71071 |
| Hermann Kolanoski | 145 | 1279 | 96152 |
| Paul Jackson | 141 | 1372 | 93464 |
| Alan Ashworth | 134 | 578 | 72089 |
| Conor Henderson | 133 | 1387 | 88725 |
| David Smith | 129 | 2184 | 100917 |
| Stuart J. Connolly | 125 | 610 | 75925 |
| G. Merino | 123 | 687 | 66163 |
| Richard J.H. Smith | 118 | 1308 | 61779 |
| Yong-Guan Zhu | 115 | 684 | 46973 |