Institution
Queen's University Belfast
Education•Belfast, United Kingdom•
About: Queen's University Belfast is a education organization based out in Belfast, United Kingdom. It is known for research contribution in the topics: Population & Context (language use). The organization has 25457 authors who have published 55463 publications receiving 1751346 citations. The organization is also known as: Queen's College, Belfast & Queen's College.
Topics: Population, Context (language use), Laser, Catalysis, Ionic liquid
Papers published on a yearly basis
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University of Liverpool1, Charles University in Prague2, Cardiff University3, Katholieke Universiteit Leuven4, Queen's University Belfast5, Howard University6, Prince of Songkla University7, Universidad Autónoma Metropolitana8, University of Hong Kong9, University of the Western Cape10, Stellenbosch University11, University of Copenhagen12, University of California, San Francisco13, University of Bergen14, Baylor College of Medicine15, University of Greifswald16, National University of Singapore17, University College Cork18
TL;DR: This study supports the hypothesis that parental attitudes significantly impact on the establishment of habits favourable to oral health, particularly in families from deprived and non-deprived backgrounds.
Abstract: Objective: The aim of this international study was to develop a valid and reliable psychometric measure to examine the extent to which parents' attitudes about engaging in twice-daily tooth brushing and controlling sugar snacking predict these respective behaviours in their children. A supplementary objective was to assess whether ethnic group, culture, level of deprivation or children's caries experience impact upon the relationships between oral health related behaviours, attitudes to these respective behaviours and to dental caries. Clinical setting: Nurseries, health centres and dental clinics in 17 countries. Participants: 2822 children aged 3 to 4 years and their parents. Main outcome measures: Dental examination of children and questionnaire to parents. Results: Factor analysis identified 8 coherent attitudes towards toothbrushing, sugar snacking and childhood caries. Attitudes were significantly different in families from deprived and non-deprived backgrounds and in families of children with and without caries. Parents perception of their ability to control their children's toothbrushing and sugar snacking habits were the most significant predictor of whether or not favourable habits were reported. Some differences were found by site and ethnic group. Conclusions: This study supports the hypothesis that parental attitudes significantly impact on the establishment of habits favourable to oral health. An appreciation of the impact of cultural and ethnic diversity is important in understanding how parental attitudes to oral health vary. Further research should examine in a prospective intervention whether enhancing parenting skills is an effective route to preventing childhood caries.
244 citations
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Harvard University1, University of Maryland, College Park2, Space Telescope Science Institute3, Michigan State University4, University of Illinois at Urbana–Champaign5, University of Hawaii at Manoa6, University of Edinburgh7, University of Texas at Austin8, Johns Hopkins University9, Queen's University Belfast10, California Institute of Technology11, Princeton University12
TL;DR: The Pan-STARRS1 discovery of the long-lived and blue transient PS1-11af was also detected by Galaxy Evolution Explorer with coordinated observations in the near-ultraviolet (NUV) band as discussed by the authors.
Abstract: We present the Pan-STARRS1 discovery of the long-lived and blue transient PS1-11af, which was also detected by Galaxy Evolution Explorer with coordinated observations in the near-ultraviolet (NUV) band. PS1-11af is associated with the nucleus of an early type galaxy at redshift z = 0.4046 that exhibits no evidence for star formation or active galactic nucleus activity. Four epochs of spectroscopy reveal a pair of transient broad absorption features in the UV on otherwise featureless spectra. Despite the superficial similarity of these features to P-Cygni absorptions of supernovae (SNe), we conclude that PS1-11af is not consistent with the properties of known types of SNe. Blackbody fits to the spectral energy distribution are inconsistent with the cooling, expanding ejecta of a SN, and the velocities of the absorption features are too high to represent material in homologous expansion near a SN photosphere. However, the constant blue colors and slow evolution of the luminosity are similar to previous optically selected tidal disruption events (TDEs). The shape of the optical light curve is consistent with models for TDEs, but the minimum accreted mass necessary to power the observed luminosity is only ~0.002 M ☉, which points to a partial disruption model. A full disruption model predicts higher bolometric luminosities, which would require most of the radiation to be emitted in a separate component at high energies where we lack observations. In addition, the observed temperature is lower than that predicted by pure accretion disk models for TDEs and requires reprocessing to a constant, lower temperature. Three deep non-detections in the radio with the Very Large Array over the first two years after the event set strict limits on the production of any relativistic outflow comparable to Swift J1644+57, even if off-axis.
243 citations
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TL;DR: It is suggested that cell surface expression of CD44 on prostate and breast cancer cells may promote the retention of a HA coat that facilitates their initial arrest on bone marrow endothelium.
Abstract: The aim of this current study was to examine the significance of CD44 expression in mediating cancer cell adhesion to human bone marrow endothelial cell(s) (hBMEC). Differential CD44 expression on two metastatic prostate cancer cell lines, PC3 (CD44 +ve) and DU145 (CD44 -ve) and four breast cancer cell lines was confirmed by immunoblotting and immunocytochemistry. In cell adhesion assays, PC3 but not DU145 cells demonstrated a rapid adhesion to hBMECs. Treatment of PC3 cells with a neutralizing antibody against CD44 standard (CD44s) and CD44 splice variants decreased PC3 cell adhesion to hBMECs. Similarly, depletion of CD44 expression using RNA interference decreased the ability of PC3 cells and two CD44 +ve breast cancer cell lines (MDA-MB-231 and MDA-MB-157) to bind FITC-conjugated hyaluronan (FITC-HA) and to adhere to hBMECs. In contrast, transfection of DU145 cells or the T47D and MCF-7 breast cancer cell lines to express CD44s increased cell surface binding of FITC-HA and cell adherence to hBMECs. Treatment of PC3 and MDA-MD-231 cells but not hBMECs with hyaluronidase attenuated cell adhesion, suggesting that cell surface expression of CD44 on prostate and breast cancer cells may promote the retention of a HA coat that facilitates their initial arrest on bone marrow endothelium.
243 citations
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TL;DR: Deteriorating health status was the central theme derived from this analysis and an earlier and more effective implementation of the palliative care approach is necessary if the needs of patients in the final stages of chronic illness are to be adequately addressed.
Abstract: Background : There is consensus in the literature that the end of life care for patients with chronic illness is suboptimal, but research on the specific needs of this population is limited Aim : This study aimed to use a mixed methodology and case study approach to explore the palliative care needs of patients with a non-cancer diagnosis from the perspectives of the patient, their significant other and the clinical team responsible for their care Patients (n = 18) had a diagnosis of either end-stage heart failure, renal failure or respiratory disease Methods : The Short Form 36 and Hospital and Anxiety and Depression Questionnaire were completed by all patients Unstructured interviews were (n = 35) were conducted separately with each patient and then their significant other These were followed by a focus group discussion (n = 18) with the multiprofessional clinical team Quantitative data were analysed using simple descriptive statistics and simple descriptive statistics All qualitative data were t
243 citations
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TL;DR: This work reviews the diversity of approaches and current progress made by national genomic-medicine initiatives in the UK, France, Australia, and US and provides a roadmap for sharing strategies, standards, and data internationally to accelerate implementation.
Abstract: Genomic sequencing is rapidly transitioning into clinical practice, and implementation into healthcare systems has been supported by substantial government investment, totaling over US$4 billion, in at least 14 countries. These national genomic-medicine initiatives are driving transformative change under real-life conditions while simultaneously addressing barriers to implementation and gathering evidence for wider adoption. We review the diversity of approaches and current progress made by national genomic-medicine initiatives in the UK, France, Australia, and US and provide a roadmap for sharing strategies, standards, and data internationally to accelerate implementation.
243 citations
Authors
Showing all 25808 results
Name | H-index | Papers | Citations |
---|---|---|---|
George Davey Smith | 224 | 2540 | 248373 |
David J. Hunter | 213 | 1836 | 207050 |
Grant W. Montgomery | 157 | 926 | 108118 |
Caroline S. Fox | 155 | 599 | 138951 |
Debbie A Lawlor | 147 | 1114 | 101123 |
Markus Ackermann | 146 | 610 | 71071 |
Hermann Kolanoski | 145 | 1279 | 96152 |
Paul Jackson | 141 | 1372 | 93464 |
Alan Ashworth | 134 | 578 | 72089 |
Conor Henderson | 133 | 1387 | 88725 |
David Smith | 129 | 2184 | 100917 |
Stuart J. Connolly | 125 | 610 | 75925 |
G. Merino | 123 | 687 | 66163 |
Richard J.H. Smith | 118 | 1308 | 61779 |
Yong-Guan Zhu | 115 | 684 | 46973 |