Showing papers by "Rovira i Virgili University published in 2014"
TL;DR: The new concept of smart health is introduced, which is the context-aware complement of mobile health within smart cities and discusses the main challenges and opportunities that s-Health would imply and provide a common ground for further research.
Abstract: The new era of mobile health ushered in by the wide adoption of ubiquitous computing and mobile communications has brought opportunities for governments and companies to rethink their concept of healthcare. Simultaneously, the worldwide urbanization process represents a formidable challenge and attracts attention toward cities that are expected to gather higher populations and provide citizens with services in an efficient and human manner. These two trends have led to the appearance of mobile health and smart cities. In this article we introduce the new concept of smart health, which is the context-aware complement of mobile health within smart cities. We provide an overview of the main fields of knowledge that are involved in the process of building this new concept. Additionally, we discuss the main challenges and opportunities that s-Health would imply and provide a common ground for further research.
530 citations
TL;DR: Fundamental mechanisms to perform exploration of a city using the multiple transportation layers using random walks on multilayer networks are introduced, and it is shown how the topological structure, together with the navigation strategy, influences the efficiency in exploring the whole structure.
Abstract: Assessing the navigability of interconnected networks (transporting information, people, or goods) under eventual random failures is of utmost importance to design and protect critical infrastructures. Random walks are a good proxy to determine this navigability, specifically the coverage time of random walks, which is a measure of the dynamical functionality of the network. Here, we introduce the theoretical tools required to describe random walks in interconnected networks accounting for structure and dynamics inherent to real systems. We develop an analytical approach for the covering time of random walks in interconnected networks and compare it with extensive Monte Carlo simulations. Generally speaking, interconnected networks are more resilient to random failures than their individual layers per se, and we are able to quantify this effect. As an application––which we illustrate by considering the public transport of London––we show how the efficiency in exploring the multiplex critically depends on layers’ topology, interconnection strengths, and walk strategy. Our findings are corroborated by data-driven simulations, where the empirical distribution of check-ins and checks-out is considered and passengers travel along fastest paths in a network affected by real disruptions. These findings are fundamental for further development of searching and navigability strategies in real interconnected systems.
475 citations
Complutense University of Madrid1, University of Alcalá2, University of Adelaide3, University of the Basque Country4, Berkeley Geochronology Center5, American Museum of Natural History6, Centre national de la recherche scientifique7, United States Geological Survey8, University of Burgos9, Rovira i Virgili University10, University of Zaragoza11, National Taiwan University12
TL;DR: The sample shows a consistent morphological pattern with derived Neandertal features present in the face and anterior vault, many of which are related to the masticatory apparatus, pointing to a mosaic pattern of evolution.
Abstract: Seventeen Middle Pleistocene crania from the Sima de los Huesos site (Atapuerca, Spain) are analyzed, including seven new specimens. This sample makes it possible to thoroughly characterize a Middle Pleistocene hominin paleodeme and to address hypotheses about the origin and evolution of the Neandertals. Using a variety of techniques, the hominin-bearing layer could be reassigned to a period around 430,000 years ago. The sample shows a consistent morphological pattern with derived Neandertal features present in the face and anterior vault, many of which are related to the masticatory apparatus. This suggests that facial modification was the first step in the evolution of the Neandertal lineage, pointing to a mosaic pattern of evolution, with different anatomical and functional modules evolving at different rates.
346 citations
TL;DR: The molecular mechanisms that underlie the pathophysiological changes of hepatic lipid metabolism that contribute to non-alcoholic fatty liver disease are discussed.
Abstract: Non-alcoholic fatty liver disease (NAFLD) is a clinicopathological change characterized by the accumulation of triglycerides in hepatocytes and has frequently been associated with obesity, type 2 diabetes mellitus, hyperlipidemia, and insulin resistance. It is an increasingly recognized condition that has become the most common liver disorder in developed countries, affecting over one-third of the population and is associated with increased cardiovascular- and liver-related mortality. NAFLD is a spectrum of disorders, beginning as simple steatosis. In about 15% of all NAFLD cases, simple steatosis can evolve into non-alcoholic steatohepatitis, a medley of inflammation, hepatocellular injury, and fibrosis, often resulting in cirrhosis and even hepatocellular cancer. However, the molecular mechanism underlying NAFLD progression is not completely understood. Its pathogenesis has often been interpreted by the "double-hit" hypothesis. The primary insult or the "first hit" includes lipid accumulation in the liver, followed by a "second hit" in which proinflammatory mediators induce inflammation, hepatocellular injury, and fibrosis. Nowadays, a more complex model suggests that fatty acids (FAs) and their metabolites may be the true lipotoxic agents that contribute to NAFLD progression; a multiple parallel hits hypothesis has also been suggested. In NAFLD patients, insulin resistance leads to hepatic steatosis via multiple mechanisms. Despite the excess hepatic accumulation of FAs in NAFLD, it has been described that not only de novo FA synthesis is increased, but FAs are also taken up from the serum. Furthermore, a decrease in mitochondrial FA oxidation and secretion of very-low-density lipoproteins has been reported. This review discusses the molecular mechanisms that underlie the pathophysiological changes of hepatic lipid metabolism that contribute to NAFLD.
320 citations
TL;DR: The main findings were that frequent vacuum cleaning resulted in lower FR concentrations in dust and that dermal contact with dust was as important for the intake of organophosphate FRs as dust ingestion.
Abstract: This study investigates the occurrence of 37 organohalogen and organophosphate flame retardants (FRs) from Norwegian households (n = 48) and classrooms from two primary schools (n = 6). Around 80% of the targeted FRs were detected in air and dust from the sampling sites. The comparison of settled dust with floor dust revealed no statistical differences between median concentrations of the FRs (n = 12). Decabromodiphenyl ether and tris(2-butoxyethyl) phosphate showed the highest median floor dust concentrations in both environments. In the air samples, the highest concentrations were observed for 2,2',4,4'-tetrabromodiphenyl ether and tris(1-chloro-2-propyl) phosphate. Remarkably, the emerging FR, 4-(1,2-dibromoethyl)-1,2-dibromocyclohexane, abbreviated as TBECH or DBE-DBCH, showed the highest indoor air concentrations reported in the literature (households, 77.9 pg/m(3) and schools, 46.6 pg/m(3)). Good Spearman correlations between the FR concentrations in dust and air (0.36 < R < 0.76) showed that is possible to estimate the concentrations in air from analyzed dust, or vice versa. Sources and pathways of exposure to FRs were assessed for the households. The main findings were that frequent vacuum cleaning resulted in lower FR concentrations in dust and that dermal contact with dust, for both children and mothers, was as important for the intake of organophosphate FRs as dust ingestion.
312 citations
TL;DR: The main finding is the existence of a metacritical point, rooted in the competition principle and holds for a large set of scenarios where the awareness spreading does not imply total immunization, and where infectiondoes not imply immediate awareness of it.
Abstract: Epidemiclike spreading processes on top of multilayered interconnected complex networks reveal a rich phase diagram of intertwined competition effects. A recent study by the authors [C. Granell et al., Phys. Rev. Lett. 111, 128701 (2013).] presented an analysis of the interrelation between two processes accounting for the spreading of an epidemic, and the spreading of information awareness to prevent infection, on top of multiplex networks. The results in the case in which awareness implies total immunization to the disease revealed the existence of a metacritical point at which the critical onset of the epidemics starts, depending on completion of the awareness process. Here we present a full analysis of these critical properties in the more general scenario where the awareness spreading does not imply total immunization, and where infection does not imply immediate awareness of it. We find the critical relation between the two competing processes for a wide spectrum of parameters representing the interaction between them. We also analyze the consequences of a massive broadcast of awareness (mass media) on the final outcome of the epidemic incidence. Importantly enough, the mass media make the metacritical point disappear. The results reveal that the main finding, i.e., existence of a metacritical point, is rooted in the competition principle and holds for a large set of scenarios.
292 citations
TL;DR: muxViz as discussed by the authors is a collection of algorithms for the analysis of multilayer networks, which are an important way to represent a large variety of complex systems throughout science and engineering.
Abstract: Multilayer relationships among entities and information about entities must be accompanied by the means to analyze, visualize, and obtain insights from such data. We present open-source software (muxViz) that contains a collection of algorithms for the analysis of multilayer networks, which are an important way to represent a large variety of complex systems throughout science and engineering. We demonstrate the ability of muxViz to analyze and interactively visualize multilayer data using empirical genetic, neuronal, and transportation networks. Our software is available at this https URL.
283 citations
Centraalbureau voor Schimmelcultures1, University of Johannesburg2, Beijing Forestry University3, Royal Botanic Gardens4, Rovira i Virgili University5, University of Pretoria6, Universidade Federal de Viçosa7, Martin Luther University of Halle-Wittenberg8, Federal University of Bahia9, Polytechnic University of Valencia10, Madawalabu University11, Chiang Mai University12, University of Alcalá13, University of Foggia14, University of Texas Health Science Center at San Antonio15, University of the Republic16, Air Force Research Laboratory17, University of Findlay18, University of Sydney19
TL;DR: In this article, a number of microfungi were described from South Africa, including Cercosporella dolichandrae from Dolichandra unguiscati, Seiridium podocarpi from Podocarpus latifolius, Pseudocercospora parapseudarthriae from Pseudarthria hookeri, Neodevriesia coryneliae from Corynelia uberata on leaves of Afrocarpus falcatus, Ramichloridium eucleae from Euclea undulata and
Abstract: Novel species of microfungi described in the present study include the following from South Africa: Cercosporella dolichandrae from Dolichandra unguiscati, Seiridium podocarpi from Podocarpus latifolius, Pseudocercospora parapseudarthriae from Pseudarthria hookeri, Neodevriesia coryneliae from Corynelia uberata on leaves of Afrocarpus falcatus, Ramichloridium eucleae from Euclea undulata and Stachybotrys aloeticola from Aloe sp. (South Africa), as novel member of the Stachybotriaceae fam. nov. Several species were also described from Zambia, and these include Chaetomella zambiensis on unknown Fabaceae, Schizoparme pseudogranati from Terminalia stuhlmannii, Diaporthe isoberliniae from Isoberlinia angolensis, Peyronellaea combreti from Combretum mossambiciensis, Zasmidium rothmanniae and Phaeococcomyces rothmanniae from Rothmannia engleriana, Diaporthe vangueriae from Vangueria infausta and Diaporthe parapterocarpi from Pterocarpus brenanii. Novel species from the Netherlands include: Stagonospora trichophoricola, Keissleriella trichophoricola and Dinemasporium trichophoricola from Trichophorum cespitosum, Phaeosphaeria poae, Keissleriella poagena, Phaeosphaeria poagena, Parastagonospora poagena and Pyrenochaetopsis poae from Poa sp., Septoriella oudemansii from Phragmites australis and Dendryphion europaeum from Hedera helix (Germany) and Heracleum sphondylium (the Netherlands). Novel species from Australia include: Anungitea eucalyptorum from Eucalyptus leaf litter, Beltraniopsis neolitseae and Acrodontium neolitseae from Neolitsea australiensis, Beltraniella endiandrae from Endiandra introrsa, Phaeophleospora parsoniae from Parsonia straminea, Penicillifer martinii from Cynodon dactylon, Ochroconis macrozamiae from Macrozamia leaf litter, Triposporium cycadicola, Circinotrichum cycadis, Cladosporium cycadicola and Acrocalymma cycadis from Cycas spp. Furthermore, Vermiculariopsiella dichapetali is described from Dichapetalum rhodesicum (Botswana), Marasmius vladimirii from leaf litter (India), Ophiognomonia acadiensis from Picea rubens (Canada), Setophoma vernoniae from Vernonia polyanthes and Penicillium restingae from soil (Brazil), Pseudolachnella guaviyunis from Myrcianthes pungens (Uruguay) and Pseudocercospora neriicola from Nerium oleander (Italy). Novelties from Spain include: Dendryphiella eucalyptorum from Eucalyptus globulus, Conioscypha minutispora from dead wood, Diplogelasinospora moalensis and Pseudoneurospora canariensis from soil and Inocybe lanatopurpurea from reforested woodland of Pinus spp. Novelties from France include: Kellermania triseptata from Agave angustifolia, Zetiasplozna acaciae from Acacia melanoxylon, Pyrenochaeta pinicola from Pinus sp. and Pseudonectria rusci from Ruscus aculeatus. New species from China include: Dematiocladium celtidicola from Celtis bungeana, Beltrania pseudorhombica, Chaetopsina beijingensis and Toxicocladosporium pini from Pinus spp. and Setophaeosphaeria badalingensis from Hemerocallis fulva. Novel genera of Ascomycetes include Alfaria from Cyperus esculentus (Spain), Rinaldiella from a contaminated human lesion (Georgia), Hyalocladosporiella from Tectona grandis (Brazil), Pseudoacremonium from Saccharum spontaneum and Melnikomyces from leaf litter (Vietnam), Annellosympodiella from Juniperus procera (Ethiopia), Neoceratosperma from Eucalyptus leaves (Thailand), Ramopenidiella from Cycas calcicola (Australia), Cephalotrichiella from air in the Netherlands, Neocamarosporium from Mesembryanthemum sp. and Acervuloseptoria from Ziziphus mucronata (South Africa) and Setophaeosphaeria from Hemerocallis fulva (China). Several novel combinations are also introduced, namely for Phaeosphaeria setosa as Setophaeosphaeria setosa, Phoma heteroderae as Peyronellaea heteroderae and Phyllosticta maydis as Peyronellaea maydis. Morphological and culture characteristics along with ITS DNA barcodes are provided for all taxa.
276 citations
Carlos III Health Institute1, Rovira i Virgili University2, Harvard University3, University of Navarra4, Barcelona Biomedical Research Park5, University of Barcelona6, University of Valencia7, University of Málaga8, University of Las Palmas de Gran Canaria9, Bellvitge University Hospital10, Spanish National Research Council11
TL;DR: Olive oil consumption, specifically the extra-virgin variety, is associated with reduced risks of cardiovascular disease and mortality in individuals at high cardiovascular risk.
Abstract: Background: It is unknown whether individuals at high cardiovascular risk sustain a benefit in cardiovascular disease from increased olive oil consumption. The aim was to assess the association between total olive oil intake, its varieties (extra virgin and common olive oil) and the risk of cardiovascular disease and mortality in a Mediterranean population at high cardiovascular risk. Methods: We included 7,216 men and women at high cardiovascular risk, aged 55 to 80 years, from the PREvencion con DIeta MEDiterranea (PREDIMED) study, a multicenter, randomized, controlled, clinical trial. Participants were randomized to one of three interventions: Mediterranean Diets supplemented with nuts or extra-virgin olive oil, or a control low-fat diet. The present analysis was conducted as an observational prospective cohort study. The median follow-up was 4.8 years. Cardiovascular disease (stroke, myocardial infarction and cardiovascular death) and mortality were ascertained by medical records and National Death Index. Olive oil consumption was evaluated with validated food frequency questionnaires. Multivariate Cox proportional hazards and generalized estimating equations were used to assess the association between baseline and yearly repeated measurements of olive oil intake, cardiovascular disease and mortality. Results: During follow-up, 277 cardiovascular events and 323 deaths occurred. Participants in the highest energy-adjusted tertile of baseline total olive oil and extra-virgin olive oil consumption had 35% (HR: 0.65; 95% CI: 0.47 to 0.89) and 39% (HR: 0.61; 95% CI: 0.44 to 0.85) cardiovascular disease risk reduction, respectively, compared to the reference. Higher baseline total olive oil consumption was associated with 48% (HR: 0.52; 95% CI: 0.29 to 0.93) reduced risk of cardiovascular mortality. For each 10 g/d increase in extra-virgin olive oil consumption, cardiovascular disease and mortality risk decreased by 10% and 7%, respectively. No significant associations were found for cancer and all-cause mortality. The associations between cardiovascular events and extra virgin olive oil intake were significant in the Mediterranean diet intervention groups and not in the control group. Conclusions: Olive oil consumption, specifically the extra-virgin variety, is associated with reduced risks of cardiovascular disease and mortality in individuals at high cardiovascular risk.
274 citations
TL;DR: Gold(i) controls complex transformations proceeding through carbocationic species by stabilising the key reactive intermediates.
272 citations
TL;DR: A Mediterranean diet supplemented with either extra virgin olive oil or nuts is not associated with the onset of metabolic syndrome, but such diets are more likely to cause reversion of the condition.
Abstract: Background: Little evidence exists on the effect of an energy-unrestricted healthy diet on metabolic syndrome. We evaluated the long-term effect of Mediterranean diets ad libitum on the incidence or reversion of metabolic syndrome. Methods: We performed a secondary analysis of the PREDIMED trial — a multicentre, randomized trial done between October 2003 and December 2010 that involved men and women (age 55–80 yr) at high risk for cardiovascular disease. Participants were randomly assigned to 1 of 3 dietary interventions: a Mediterranean diet supplemented with extra-virgin olive oil, a Mediterranean diet supplemented with nuts or advice on following a low-fat diet (the control group). The interventions did not include increased physical activity or weight loss as a goal. We analyzed available data from 5801 participants. We determined the effect of diet on incidence and reversion of metabolic syndrome using Cox regression analysis to calculate hazard ratios (HRs) and 95% confidence intervals (CIs). Results: Over 4.8 years of follow-up, metabolic syndrome developed in 960 (50.0%) of the 1919 participants who did not have the condition at baseline. The risk of developing metabolic syndrome did not differ between participants assigned to the control diet and those assigned to either of the Mediterranean diets (control v. olive oil HR 1.10, 95% CI 0.94–1.30, p = 0.231; control v. nuts HR 1.08, 95% CI 0.92–1.27, p = 0.3). Reversion occurred in 958 (28.2%) of the 3392 participants who had metabolic syndrome at baseline. Compared with the control group, participants on either Mediterranean diet were more likely to undergo reversion (control v. olive oil HR 1.35, 95% CI 1.15–1.58, p p p = 0.02); participants in the group supplemented with nuts showed a significant decrease in central obesity. Interpretation: A Mediterranean diet supplemented with either extra virgin olive oil or nuts is not associated with the onset of metabolic syndrome, but such diets are more likely to cause reversion of the condition. An energy-unrestricted Mediterranean diet may be useful in reducing the risks of central obesity and hyperglycemia in people at high risk of cardiovascular disease. Trial registration: ClinicalTrials.gov, no. ISRCTN35739639.
TL;DR: In this paper, a meeting of leading scholars of firm growth and innovation has been organized to shed light on the link between firm's growth and its innovation sources, and the results of the workshop have been presented at the workshop on "Firm Growth and Innovation" held on 28 and 29 June 2012, in Tarragona, Spain.
Abstract: In recent years, there has been an increase in empirical and theoretical work that addresses the role of innovation as one of the main sources of firm growth. The purpose of this special issue is to strengthen the role played by innovation as a determinant of firm growth. Despite the emergence of a vast empirical literature on whether innovative firms grow more quickly in terms of sales and employees, a number of crucial questions and answers remain. While a large number of applied papers observe a positive link between innovation and firm growth, the complexity of R&D activities, together with the diversity of innovation strategies and the multiplicity of growth modes, requires a multidimensional approach to examine the contribution of innovations on firm growth. To shed light on the link between firm’ growth and innovation sources, we organized a meeting of leading scholars of firm’ growth and innovation. The papers of this special issue were presented at the workshop on ‘Firm growth and innovation’ held on 28 and 29 June, 2012, in Tarragona, Spain. The papers that compose this special issue deal in depth with innovation activity, firm growth and the interaction between firm growth and innovation.
01 Dec 2014
TL;DR: In this paper, the authors present an inventory of existing approaches, privacy design strategies, and technical building blocks of various degrees of maturity from research and development, and sketch a method to map legal obligations to design strategies.
Abstract: Privacy and data protection constitute core values of individuals and of democratic societies. There have been decades of debate on how those values -and legal obligations- can be embedded into systems, preferably from the very beginning of the design process. One important element in this endeavour are technical mechanisms, known as privacy-enhancing technologies (PETs). Their effectiveness has been demonstrated by researchers and in pilot implementations. However, apart from a few exceptions, e.g., encryption became widely used, PETs have not become a standard and widely used component in system design. Furthermore, for unfolding their full benefit for privacy and data protection, PETs need to be rooted in a data governance strategy to be applied in practice. This report contributes to bridging the gap between the legal framework and the available technological implementation measures by providing an inventory of existing approaches, privacy design strategies, and technical building blocks of various degrees of maturity from research and development. Starting from the privacy principles of the legislation, important elements are presented as a first step towards a design process for privacy-friendly systems and services. The report sketches a method to map legal obligations to design strategies, which allow the system designer to select appropriate techniques for implementing the identified privacy requirements. Furthermore, the report reflects limitations of the approach. It concludes with recommendations on how to overcome and mitigate these limits.
TL;DR: In this article, the authors discussed the challenges encountered during the application of the Social Life Cycle Assessment (SLCA) methodology defined by UNEP/SETAC S-LCA guidelines in a case study under the framework of life cycle sustainability assessment.
TL;DR: In this article, the extent to which innovative Spanish firms pursue improvements in energy efficiency (EE) within their innovation objectives is examined, using a panel data coming from CIS (Community Innovation Survey) for the period 2008-2011 that includes 4,458 manufacturing firms.
Abstract: This paper examines the extent to which innovative Spanish firms pursue improvements in energy efficiency (EE) within their innovation objectives. The increase in energy consumption and its impact on greenhouse gas emissions justifies the greater attention being paid to energy efficiency and especially to industrial EE. The ability of manufacturing companies to innovate and improve their EE has a substantial influence on reaching the objectives regarding climate change mitigation. Despite the effort to design more efficient energy policies, the EE determinants in manufacturing firms have been little studied in the empirical literature. From an exhaustive sample of Spanish manufacturing firms and using a probit model, we examine the energy efficiency determinants to those firms that have innovated. To carry out the econometric analysis, we use a panel data coming from CIS (Community Innovation Survey) for the period 2008-2011 that includes 4,458 manufacturing firms. Among firm characteristics, the empirical results underline the importance of size in facilitating the adoption of technology that improves energy efficiency; while among the factors related to companies’ behavior, the favorable influence of organizational innovations and innovations related with the reduction of environmental impacts stand out as the main factors in carrying out innovations with the objective of increasing energy efficiency.
TL;DR: Density functional theory (DFT) studies combined with kinetic data provides a rational for the relative high activity found for these Al(III) complexes, and the data are consistent with a monometallic mechanism.
Abstract: AlIII complexes of amino-tris(phenolate) ligand scaffolds have been prepared to attain highly Lewis acidic catalysts. Combination of the aforementioned systems with ammonium halides provides highly active catalysts for the synthesis of organic carbonates through addition of carbon dioxide to oxiranes with initial turnover frequencies among the highest reported to date within the context of cyclic carbonate formation. Density functional theory (DFT) studies combined with kinetic data provides a rational for the relative high activity found for these AlIII complexes, and the data are consistent with a monometallic mechanism. The activity and versatility of these AlIII complexes has also been evaluated against some state-of-the-art catalysts and the combined results compare favorably in terms of catalyst construction, stability, activity, and applicability.
TL;DR: Environmental monitoring studies are required not only to assure that the current state of pollution of Pardo River does not mean a risk for the riverside population, but also to assess the potential trends in the environmental levels of those elements.
TL;DR: It is found that synchronization is promoted by strong alignments between frequencies and the dominant Laplacian eigenvectors, as well as a matching between the heterogeneity of frequencies and network structure.
Abstract: We study optimal synchronization in networks of heterogeneous phase oscillators. Our main result is the derivation of a synchrony alignment function that encodes the interplay between network structure and oscillators' frequencies and that can be readily optimized. We highlight its utility in two general problems: constrained frequency allocation and network design. In general, we find that synchronization is promoted by strong alignments between frequencies and the dominant Laplacian eigenvectors, as well as a matching between the heterogeneity of frequencies and network structure.
TL;DR: This paper presents a unifying framework that aims to improve the understanding of semantic measures, to highlight their equivalences and to propose bridges between their theoretical bases, and unify a large number of state-of-the-art semantic similarity measures through common expressions.
TL;DR: The findings at Barranc de la Boella suggest that early LCT lithic assemblages appeared in the SW of Europe during earlier hominin dispersal episodes before the definitive colonization of temperate Eurasia took place.
Abstract: The first arrivals of hominin populations into Eurasia during the Early Pleistocene are currently considered to have occurred as short and poorly dated biological dispersions. Questions as to the tempo and mode of these early prehistoric settlements have given rise to debates concerning the taxonomic significance of the lithic assemblages, as trace fossils, and the geographical distribution of the technological traditions found in the Lower Palaeolithic record. Here, we report on the Barranc de la Boella site which has yielded a lithic assemblage dating to ,1 million years ago that includes large cutting tools (LCT). We argue that distinct technological traditions coexisted in the Iberian archaeological repertoires of the late Early Pleistocene age in a similar way to the earliest sub-Saharan African artefact assemblages. These differences between stone tool assemblages may be attributed to the different chronologies of hominin dispersal events. The archaeological record of Barranc de la Boella completes the geographical distribution of LCT assemblages across southern Eurasia during the EMPT (Early-Middle Pleistocene Transition, circa 942 to 641 kyr). Up to now, chronology of the earliest European LCT assemblages is based on the abundant Palaeolithic record found in terrace river sequences which have been dated to the end of the EMPT and later. However, the findings at Barranc de la Boella suggest that early LCT lithic assemblages appeared in the SW of Europe during earlier hominin dispersal episodes before the definitive colonization of temperate Eurasia took place.
Centraalbureau voor Schimmelcultures1, University of Pretoria2, Royal Botanic Gardens3, Rovira i Virgili University4, Kunming Institute of Botany5, King Saud University6, Mae Fah Luang University7, University of Calcutta8, University of Alcalá9, Madawalabu University10, Universidad de las Américas Puebla11, Murdoch University12, American Museum of Natural History13, Université catholique de Louvain14, California Department of Fish and Wildlife15, Mie University16, United States Department of Agriculture17, University of the Free State18, University of Johannesburg19, Beijing Forestry University20
TL;DR: Novel species of fungi described in the present study include the following from South Africa; and Diaporthe acaciarum and Roussoella acacia are newly described from Acacia tortilis in Tanzania.
Abstract: Novel species of fungi described in the present study include the following from South Africa: Alanphillipsia aloeicola from Aloe sp., Arxiella dolichandrae from Dolichandra unguiscati, Ganoderma austroafricanum from Jacaranda mimosifolia, Phacidiella podocarpi and Phaeosphaeria podocarpi from Podocarpus latifolius, Phyllosticta mimusopisicola from Mimusops zeyheri and Sphaerulina pelargonii from Pelargonium sp. Furthermore, Barssia maroccana is described from Cedrus atlantica (Morocco), Codinaea pini from Pinus patula (Uganda), Crucellisporiopsis marquesiae from Marquesia acuminata (Zambia), Dinemasporium ipomoeae from Ipomoea pes-caprae (Vietnam), Diaporthe phragmitis from Phragmites australis (China), Marasmius vladimirii from leaf litter (India), Melanconium hedericola from Hedera helix (Spain), Pluteus albotomentosus and Pluteus extremiorientalis from a mixed forest (Russia), Rachicladosporium eucalypti from Eucalyptus globulus (Ethiopia), Sistotrema epiphyllum from dead leaves of Fagus sylvatica in a forest (The Netherlands), Stagonospora chrysopyla from Scirpus microcarpus (USA) and Trichomerium dioscoreae from Dioscorea sp. (Japan). Novel species from Australia include: Corynespora endiandrae from Endiandra introrsa, Gonatophragmium triuniae from Triunia youngiana, Penicillium coccotrypicola from Archontophoenix cunninghamiana and Phytophthora moyootj from soil. Novelties from Iran include Neocamarosporium chichastianum from soil and Seimatosporium pistaciae from Pistacia vera. Xenosonderhenia eucalypti and Zasmidium eucalyptigenum are newly described from Eucalyptus urophylla in Indonesia. Diaporthe acaciarum and Roussoella acacia are newly described from Acacia tortilis in Tanzania. New species from Italy include Comoclathris spartii from Spartium junceum and Phoma tamaricicola from Tamarix gallica. Novel genera include (Ascomycetes): Acremoniopsis from forest soil and Collarina from water sediments (Spain), Phellinocrescentia from a Phellinus sp. (French Guiana), Neobambusicola from Strelitzia nicolai (South Africa), Neocladophialophora from Quercus robur (Germany), Neophysalospora from Corymbia henryi (Mozambique) and Xenophaeosphaeria from Grewia sp. (Tanzania). Morphological and culture characteristics along with ITS DNA barcodes are provided for all taxa.
TL;DR: The potential use of Er:Yb:NaY2F5O nanoparticles as lifetime based thermal probes is reported, providing the first experimental evidence on sub-tissue lifetime fluorescence thermal sensing by using up-conversion nanoparticles in an ex vivo experiment.
Abstract: Non-contact thermometry is essential in biomedical studies requiring thermal sensing and imaging with high thermal and spatial resolutions. In this work, we report the potential use of Er:Yb:NaYF4 and Er:Yb:NaY2F5O up-conversion nanoparticles as thermal sensors by means of lifetime based luminescent thermometry. We demonstrate how Er:Yb:NaY2F5O nanocrystals present a higher thermal sensitivity than the Er:Yb:NaYF4 ones and that their lifetime thermal coefficient is comparable to those corresponding to other nano-sized luminescent systems already used for high resolution lifetime fluorescence thermal sensing. We evaluate the potential use of Er:Yb:NaY2F5O nanoparticles as lifetime based thermal probes by providing the first experimental evidence on sub-tissue lifetime fluorescence thermal sensing by using up-conversion nanoparticles in an ex vivo experiment.
TL;DR: The paper describes the signal processing to estimate sleep apnea detection and breathing rate, and some techniques to solve several problems in these types of measurements, such as the clutter suppression, body movement and body orientation detection are described.
Abstract: This paper focuses on the feasibility of tracking the chest wall movement of a human subject during respiration from the waveforms recorded using an impulse-radio (IR) ultra-wideband radar. The paper describes the signal processing to estimate sleep apnea detection and breathing rate. Some techniques to solve several problems in these types of measurements, such as the clutter suppression, body movement and body orientation detection are described. Clutter suppression is achieved using a moving averaging filter to dynamically estimate it. The artifacts caused by body movements are removed using a threshold method before analyzing the breathing signal. The motion is detected using the time delay that maximizes the received signal after a clutter removing algorithm is applied. The periods in which the standard deviations of the time delay exceed a threshold are considered macro-movements and they are neglected. The sleep apnea intervals are detected when the breathing signal is below a threshold. The breathing rate is determined from the robust spectrum estimation based on Lomb periodogram algorithm. On the other hand the breathing signal amplitude depends on the body orientation respect to the antennas, and this could be a problem. In this case, in order to maximize the signal-to-noise ratio, multiple sensors are proposed to ensure that the backscattered signal can be detected by at least one sensor, regardless of the direction the human subject is facing. The feasibility of the system is compared with signals recorded by a microphone.
TL;DR: A new solid-state reference electrode using a polymeric membrane of polyvinyl butyral (PVB), Ag/AgCl and NaCl to be used in decentralized chemical measurements is presented and shows good correlation when compared with a conventional double-junction reference electrode.
TL;DR: In this paper, a mini-review focuses on the recent efforts to replace petro-based feedstocks with polybenzoxazine precursors, which have attracted significant attention from both academia and industry because of their unique advantages.
TL;DR: The development of gold(I)-catalyzed intermolecular carbo- and hetero-cycloadditions of alkynes and allenes with alkenes has been more challenging than their intramolecular counterparts.
Abstract: The development of gold(I)-catalyzed intermolecular carbo- and hetero-cycloadditions of alkynes and allenes has been more challenging than their intramolecular counterparts. Here we review, with a mechanistic perspective, the most fundamental intermolecular cycloadditions of alkynes and allenes with alkenes.
TL;DR: An economic evaluation and the harm-benefit ratios of screening strategies that vary in their intensity and interval ages based on breast cancer risk are assessed and the gain in terms of cost and harm reductions using risk-based screening with respect to the usual practice is estimated.
Abstract: The one-size-fits-all paradigm in organized screening of breast cancer is shifting towards a personalized approach. The present study has two objectives: 1) To perform an economic evaluation and to assess the harm-benefit ratios of screening strategies that vary in their intensity and interval ages based on breast cancer risk; and 2) To estimate the gain in terms of cost and harm reductions using risk-based screening with respect to the usual practice. We used a probabilistic model and input data from Spanish population registries and screening programs, as well as from clinical studies, to estimate the benefit, harm, and costs over time of 2,624 screening strategies, uniform or risk-based. We defined four risk groups, low, moderate-low, moderate-high and high, based on breast density, family history of breast cancer and personal history of breast biopsy. The risk-based strategies were obtained combining the exam periodicity (annual, biennial, triennial and quinquennial), the starting ages (40, 45 and 50 years) and the ending ages (69 and 74 years) in the four risk groups. Incremental cost-effectiveness and harm-benefit ratios were used to select the optimal strategies. Compared to risk-based strategies, the uniform ones result in a much lower benefit for a specific cost. Reductions close to 10% in costs and higher than 20% in false-positive results and overdiagnosed cases were obtained for risk-based strategies. Optimal screening is characterized by quinquennial or triennial periodicities for the low or moderate risk-groups and annual periodicity for the high-risk group. Risk-based strategies can reduce harm and costs. It is necessary to develop accurate measures of individual risk and to work on how to implement risk-based screening strategies.
TL;DR: An overview of the state of the art and the latest trends used in the literature from 2005 to the present in the analysis of drugs of abuse in hair, with a special focus on separation analytical techniques and their hyphenation with mass spectrometry detection is provided.
TL;DR: An experimentally validated numerical model is presented that can be used to predict power production with distributed maximum power point tracking (DMPPT) down to the cell level and shows that DMPPT solutions that are based on submodule integrated converters offer 6.9-11.1% improvements in annual energy yield relative to a baseline centralized MPPT scenario.
Abstract: Mismatch power losses in photovoltaic (PV) systems can be reduced by the use of distributed power electronics at the module or submodule level. This paper presents an experimentally validated numerical model that can be used to predict power production with distributed maximum power point tracking (DMPPT) down to the cell level. The model allows the investigations of different DMPPT architectures, as well as the impact of conversion efficiencies and power constraints. Results are presented for annual simulations of three representative partial shading scenarios and two scenarios where mismatches are due to aging over a period of 25 years. It is shown that DMPPT solutions that are based on submodule integrated converters offer 6.9-11.1% improvements in annual energy yield relative to a baseline centralized MPPT scenario.
TL;DR: In this paper, the authors conceptualize local tourism destinations' evolution as a complex, path-and place-dependent process that is determined by the action and interaction of stakeholders and their ability to adapt or create new paths, as well as to survive in response to local and global changes.
Abstract: Analytical approaches from emergent paradigms in economic geography – namely, evolutionary economic geography (EEG) and relational economic geography (REG) – can help to advance and integrate extant research in tourism geography on destinations’ dynamics and organisation. Taking into account concepts such as human agency, contextuality and path dependence, the paper conceptualises local tourism destinations’ evolution as a complex, path- and place-dependent process that is determined by the action and interaction of stakeholders and their ability to adapt or create new paths, as well as to survive in response to local and global changes. Hence, it discusses the bidirectional effects between stakeholder practices and local tourism destinations’ evolutionary performance. Furthermore, it attempts to increase the understanding of how and why destinations change over time, which is valuable for policy formation and to improve local tourism destinations’ competitiveness and sustainability. All in all, the paper...