Institution
United States Department of the Army
Government•Arlington, Virginia, United States•
About: United States Department of the Army is a government organization based out in Arlington, Virginia, United States. It is known for research contribution in the topics: Poison control & Population. The organization has 32668 authors who have published 42453 publications receiving 947075 citations. The organization is also known as: DA & U.S. Department of the Army.
Topics: Poison control, Population, Laser, Signal, Virus
Papers published on a yearly basis
Papers
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TL;DR: The treatment of symptomatic single-level cervical spondylosis with PCM achieves clinical outcomes that are at least equivalent to ACDF while maintaining motion and meeting radiographical criteria of motion for PCM and fusion for ACDF.
Abstract: Study design Prospective, multicenter, randomized Food and Drug Administration approved investigational device exemption clinical trial. Objective To evaluate the safety and effectiveness of the PCM Cervical Disc compared with anterior cervical discectomy and fusion (ACDF) in the treatment of patients with degenerative spondylosis and neurological symptoms at 1 level between C3-C4 and C7-T1. Summary of background data Cervical disc arthroplasty in the treatment of symptomatic cervical spondylosis has been studied in other series. The PCM Cervical Disc is a nonconstrained motion-sparing alternative to ACDF. Methods Patients 18 to 65 years of age with single-level symptomatic cervical spondylosis with radiculopathy and/or myelopathy unresponsive to nonoperative treatment were enrolled, including patients with prior nonadjacent or adjacent single-level fusions. The per-protocol patient sample at 2 years included 342 patients (189 PCM, 153 ACDF). Longitudinal outcomes were comparatively evaluated. Results At 2 years postoperatively, clinical measures-neck and arm pain visual analogue scale, Neck Disability Index (NDI), SF-36, and neurological status-were significantly improved from preoperative baselines in both groups. Mean NDI score at 2 years was significantly lower in PCM group (P = 0.029). There were no statistical differences between groups in rates of surgery-related serious adverse events (5.6% PCM, 7.4% ACDF) or secondary surgical procedures (5.2% PCM, 5.4% ACDF). Patients with PCM reported lower dysphagia scores (8.8/100 vs. 12.1/100; P = 0.045) and higher patient satisfaction (82.8/100 vs. 81.4/100). Overall success, a composite endpoint including minimum 20% NDI improvement, no major complications, no neurological worsening, no secondary surgical procedures, and meeting radiographical criteria of motion for PCM and fusion for ACDF, was significantly greater in the PCM group (75.1% vs. 64.9%; P = 0.020). Conclusion The treatment of symptomatic single-level cervical spondylosis with PCM achieves clinical outcomes that are at least equivalent to ACDF while maintaining motion. At 2 years, patients with PCM had lower NDI scores, statistically lower rate of prolonged dysphagia, greater patient satisfaction, and superior overall success.
181 citations
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TL;DR: PUR scaffolds incorporating V-FB could be a potential clinical therapy for treatment of infected bone defects as well as a biodegradable porous polyurethane system which does not require the extra surgical removal step in clinical use.
181 citations
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TL;DR: Fragment C, a approximately 50-kDa fragment, of botulinum neurotoxin serotype A was constructed from oligonucleotides and has many properties that make it a good candidate for human use to protect againstBotulinum toxin.
Abstract: A completely synthetic gene encoding fragment C, a approximately 50-kDa fragment, of botulinum neurotoxin serotype A was constructed from oligonucleotides. The gene was expressed in Escherichia coli, and full-sized product was produced as judged by Western blot (immunoblot) analysis. Crude extracts of E. coli expressing the gene were used to vaccinate mice and evaluate their survival against challenge with active toxin. Mice given three subcutaneous vaccinations were protected against an intraperitoneal administration of 10(6) 50% lethal doses (ID50) of serotype A toxin. The same mice survived when challenged with 3 LD50 of botulinum toxin serotype E but died when challenged with 10 LD50 of serotype E or 3 LD50 of serotype B. Purified fragment C was compared with the botulinum toxoid vaccine in a vaccination and challenge study. Fragment C was as efficacious in protecting against challenge with active botulinum neurotoxin serotype A as the toxoid vaccine. This recombinant protein product has many properties that make it a good candidate for human use to protect against botulinum toxin.
180 citations
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TL;DR: In this article, the anodic oxidation of cobalt in 0.2-8.0 N potassium hydroxide solutions was studied by cyclic voltammetry and the equilibrium potentials for several electrode reactions were calculated from the thermodynamic data.
180 citations
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TL;DR: In this article, a relationship between the breaker height-breaking depth ratio, the incident wave steepness and the beach slope is found, when combined with experimental observations of breaker travel, permits an estimate of the maximum breaking wave height a coastal structure might experience given a design wave period and design depth.
Abstract: Based on a re-evaluation of available experimental data on breaking waves, a relationship between the breaker height-breaking depth ratio, the incident wave steepness and the beach slope is found. This relationship, when combined with experimental observations of breaker travel, permits an estimate of the maximum breaking wave height a coastal structure might experience given a design wave period and design depth at the structure site. Breaker-type classification according to inshore and offshore parameters as presently defined cannot be reconciled to observations of the relationship between breaker-height index, wave steepness and beach slope. Revised criteria for breaker classification are presented.
180 citations
Authors
Showing all 32680 results
Name | H-index | Papers | Citations |
---|---|---|---|
David L. Kaplan | 177 | 1944 | 146082 |
Russel J. Reiter | 169 | 1646 | 121010 |
Donald G. Truhlar | 165 | 1518 | 157965 |
Jie Liu | 131 | 1531 | 68891 |
Martin A. Green | 127 | 1069 | 76807 |
William J. Kraemer | 123 | 755 | 54774 |
Steven J. Jacobsen | 123 | 662 | 62716 |
Roger H Unger | 121 | 493 | 48035 |
Thomas C. Quinn | 120 | 827 | 65881 |
John B. Holcomb | 120 | 733 | 53760 |
Stephen Mann | 120 | 669 | 55008 |
Bette T. Korber | 117 | 392 | 49526 |
Thomas G. Ksiazek | 113 | 398 | 46108 |
John R. Anderson | 112 | 538 | 84725 |
Stanley I. Rapoport | 107 | 696 | 45793 |