United States Department of the Army

About: United States Department of the Army is a government organization based out in Arlington, Virginia, United States. It is known for research contribution in the topics: Poison control & Population. The organization has 32668 authors who have published 42453 publications receiving 947075 citations. The organization is also known as: DA & U.S. Department of the Army.

On the calibration and verification of two-dimensional, distributed, Hortonian, continuous watershed models

Abstract: Physically based, two-dimensional, distributed parameter Hortonian hydrologic models are sensitive to a number of spatially varied parameters and inputs and are particularly sensitive to the initial soil moisture field. However, soil moisture data are generally unavailable for most catchments. Given an erroneous initial soil moisture field, single-event calibrations are easily achieved using different combinations of model parameters, including physically unrealistic values. Verification of single-event calibrations is very difficult for models of this type because of parameter estimation errors that arise from initial soil moisture field uncertainty. The purpose of this study is to determine if the likelihood of obtaining a verifiable calibration increases when a continuous flow record, consisting of multiple runoff producing events is used for model calibration. The physically based, two-dimensional, distributed, Hortonian hydrologic model CASC2D [Julien et al., 1995] is converted to a continuous formulation that simulates the temporal evolution of soil moisture between rainfall events. Calibration is performed using 6 weeks of record from the 21.3 km 2 Goodwin Creek Experimental Watershed, located in northern Mississippi. Model parameters are assigned based on soil textures, land use/land cover maps, and a combination of both. The sensitivity of the new model formulation to parameter variation is evaluated. Calibration is performed using the shuffled complex evolution method [Duan et al., 1991]. Three different tests are conducted to evaluate model performance based on continuous calibration. Results show that calibration on a continuous basis significantly improves model performance for periods, or subcatchments, not used in calibration and the likelihood of obtaining realistic simulations of spatially varied catchment dynamics. The automated calibration reveals that the parameter assignment methodology used in this study results in overparameterization. Additional research is needed in spatially distributed hydrologic model parameter assignment methodologies for hydrologic forecasting.

Supercontinuum generation from ~19 to 45 μmin ZBLAN fiber with high average power generation beyond 38 μm using a thulium-doped fiber amplifier

Abstract: A mid-IR supercontinuum (SC) fiber laser based on a thulium-doped fiber amplifier (TDFA) is demonstrated. A continuous spectrum extending from ∼1.9 to 4.5 μm is generated with ∼0.7 W time-average power in wavelengths beyond 3.8 μm. The laser outputs a total average power of up to ∼2.6 W from ∼8.5 m length of ZrF4─BaF2─LaF3─AlF3─NaF (ZBLAN) fiber, with an optical conversion efficiency of ∼9% from the TDFA pump to the mid-IR SC. Optimal efficiency in generating wavelengths beyond 3.8 μm is achieved by reducing the losses in the TDFA stage and optimizing the ZBLAN fiber length. We demonstrate a novel (to our knowledge) approach of generating modulation instability-initiated SC starting from 1.55 μm by splitting the spectral shifting process into two steps. In the first step, amplified approximately nanosecond-long 1.55 μm laser diode pulses with ∼2.5 kW peak power generate a SC extending beyond 2.1 μm in ∼25 m length of standard single-mode fiber (SMF). The ∼2 μm wavelength components at the standard SMF output are amplified in a TDFA and coupled into ZBLAN fiber leading to mid-IR SC generation. Up to ∼270 nm SC long wavelength edge extension and ∼2.5× higher optical conversion efficiency to wavelengths beyond 3.8 μm are achieved by switching an Er:Yb-based power amplifier stage with a TDFA. The laser also demonstrates scalability in the average output power with respect to the pulse repetition rate and the amplifier pump power. Numerical simulations are performed by solving the generalized nonlinear Schrodinger equation, which show the long wavelength edge of the SC to be limited by the loss in ZBLAN.

Rational design of small molecules as vaccine adjuvants

Abstract: Adjuvants increase vaccine potency largely by activating innate immunity and promoting inflammation. Limiting the side effects of this inflammation is a major hurdle for adjuvant use in vaccines for humans. It has been difficult to improve on adjuvant safety because of a poor understanding of adjuvant mechanism and the empirical nature of adjuvant discovery and development historically. We describe new principles for the rational optimization of small-molecule immune potentiators (SMIPs) targeting Toll-like receptor 7 as adjuvants with a predicted increase in their therapeutic indices. Unlike traditional drugs, SMIP-based adjuvants need to have limited bioavailability and remain localized for optimal efficacy. These features also lead to temporally and spatially restricted inflammation that should decrease side effects. Through medicinal and formulation chemistry and extensive immunopharmacology, we show that in vivo potency can be increased with little to no systemic exposure, localized innate immune activation and short in vivo residence times of SMIP-based adjuvants. This work provides a systematic and generalizable approach to engineering small molecules for use as vaccine adjuvants.