Institution
United States Department of the Army
Government•Arlington, Virginia, United States•
About: United States Department of the Army is a government organization based out in Arlington, Virginia, United States. It is known for research contribution in the topics: Poison control & Population. The organization has 32668 authors who have published 42453 publications receiving 947075 citations. The organization is also known as: DA & U.S. Department of the Army.
Topics: Poison control, Population, Laser, Signal, Virus
Papers published on a yearly basis
Papers
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TL;DR: Data indicate that the sulfonamides and phenytoin are the most common etiologic agents, expeditious transfer to a burn center reduces morbidity, and corticosteroid administration dramatically increases mortality in patients with TEN.
Abstract: BACKGROUND Toxic epidermal necrolysis (TEN) is a life threatening exfoliative disorder that is most commonly precipitated by the administration of a medication. Efforts to reduce morbidity and improve survival have brought into question the use of corticosteroids and recommend the transfer of patients to a burn center to facilitate wound care. STUDY DESIGN This study evaluated the correlation of measures of disease severity and impact of treatment strategies on morbidity and mortality in patients with TEN. The records of all patients with TEN admitted to the United States Army Institute of Surgical Research during a 12 year period were reviewed. Patient characteristics, etiologic agents, time to referral of patients to the burn center, corticosteroid therapy, and other demographic features were studied. Univariate and multivariate analyses were used to determine the significance of these factors with respect to outcome. RESULTS The sulfonamides and phenytoin were the most frequently identified etiologic agents. Patients at the extremes of age had a higher mortality rate. The period of hospitalization was longer in patients transferred to the burn center more than seven days after skin slough. Percent of epidermalysis, white blood cell count nadir, and corticosteroid administration for more than 48 hours were independently associated with mortality. CONCLUSIONS These data indicate that the sulfonamides and phenytoin are the most common etiologic agents, expeditious transfer to a burn center reduces morbidity, and corticosteroid administration dramatically increases mortality.
149 citations
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TL;DR: It was concluded that various bioactive molecules for bone regeneration might be efficiently incorporated with calcium phosphate-based bioceramics using biodegradable polymeric microspheres.
149 citations
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TL;DR: A biomarker-based disease activity score showed a dose-dependent decrease at week 12, indicating suppression of disease-related biological pathways, suggesting that inhibiting the mononuclear phagocyte pathway may provide a novel therapeutic approach for RA.
Abstract: Objectives Mavrilimumab, a human monoclonal antibody targeting the alpha subunit of the granulocyte-macrophage colony-stimulating factor receptor, was evaluated in a phase 2 randomised, double-blind, placebo-controlled study to investigate efficacy and safety in subjects with rheumatoid arthritis (RA). Methods Subcutaneous mavrilimumab (10 mg, 30 mg, 50 mg, or 100 mg) or placebo was administered every other week for 12 weeks in subjects on stable background methotrexate therapy. The primary endpoint was the proportion of subjects achieving a ≥1.2 decrease from baseline in Disease Activity Score (DAS28-CRP) at week 12. Results 55.7% of mavrilimumab-treated subjects met the primary endpoint versus 34.7% placebo (p=0.003) at week 12; for the 10 mg, 30 mg, 50 mg, and 100 mg groups, responses were 41.0% (p=0.543), 61.0% (p=0.011), 53.8% (p=0.071), and 66.7% (p=0.001) respectively. Response rate differences from placebo were observed at week 2 and increased throughout the treatment period. The 100 mg dose demonstrated a significant effect versus placebo on DAS28-CRP Conclusions Mavrilimumab induced rapid clinically significant responses in RA subjects, suggesting that inhibiting the mononuclear phagocyte pathway may provide a novel therapeutic approach for RA.
149 citations
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TL;DR: In this article, a three parameter Weibull distribution is fitted to the observed storm peak data giving due consideration to data censoring, and the use of the peaks over threshold method is recommended.
Abstract: Recommended methods for the statistical analysis of extreme waves are presented. Proper data selection is stressed. Data from different seasons and/or of different type or origin should be analysed separately. Use of the peaks over threshold method is recommended. It is advised that a three parameter Weibull distribution is fitted to the observed storm peak data giving due consideration to data censoring.
149 citations
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TL;DR: A new generation of tools are being developed in the following areas: interpolation from multidimensional scattered point data, analysis of surfaces and hypersurfaces, modelling of spatial processes and 3D dynamic visualization.
Abstract: The concept of GRASS (Geographic Resources Analysis Support System) as an open system has created a favourable environment for integration of process based modelling and GIS. To support this integration a new generation of tools is being developed in the following areas: (a) interpolation from multidimensional scattered point data, (b) analysis of surfaces and hypersurfaces, (c) modelling of spatial processes and, (d) 3D dynamic visualization. Examples of two applications are given-spatial and temporal modelling of erosion and deposition, and multivariate interpolation and visualization of nitrogen concentrations in the Chesapeake Bay.
148 citations
Authors
Showing all 32680 results
Name | H-index | Papers | Citations |
---|---|---|---|
David L. Kaplan | 177 | 1944 | 146082 |
Russel J. Reiter | 169 | 1646 | 121010 |
Donald G. Truhlar | 165 | 1518 | 157965 |
Jie Liu | 131 | 1531 | 68891 |
Martin A. Green | 127 | 1069 | 76807 |
William J. Kraemer | 123 | 755 | 54774 |
Steven J. Jacobsen | 123 | 662 | 62716 |
Roger H Unger | 121 | 493 | 48035 |
Thomas C. Quinn | 120 | 827 | 65881 |
John B. Holcomb | 120 | 733 | 53760 |
Stephen Mann | 120 | 669 | 55008 |
Bette T. Korber | 117 | 392 | 49526 |
Thomas G. Ksiazek | 113 | 398 | 46108 |
John R. Anderson | 112 | 538 | 84725 |
Stanley I. Rapoport | 107 | 696 | 45793 |