University of Antwerp

About: University of Antwerp is a education organization based out in Antwerp, Belgium. It is known for research contribution in the topics: Population & Context (language use). The organization has 16682 authors who have published 48837 publications receiving 1689748 citations. The organization is also known as: Universiteit Antwerpen & UAntwerp.

Sustainable development : a bird's eye view

Abstract: At the turn of the millennium, the world's political leadership adopted sustainable development as a leading model for societal development. However, the terms "sustainable development", "sustainability" and "sustainable" are sometimes over- and misused despite wide consensus about the concept's meaning among sustainability scholars and practitioners. While the concept allows various sustainability views to co-exist, random conceptualizations which do not respect the fundamental sustainability principles undermine the concept's objective to steer action. This lack of understanding of sustainability arguably inhibits its practical realization and a proper understanding of sustainability is urgently needed. In this paper we aim to contribute to a better understanding of sustainability by adopting a bird's eye perspective. We review the rich contemporary literature, with a specific focus on the terminology, genesis, fundamental principles, mainstream views of sustainability, and several governing aspects. Further, using the evolving body of sustainability literature, the paper provides arguments to combat common misconceptions of sustainability.

Traumatic Intracranial Hypertension

Abstract: This article reviews the methods of monitoring and treating traumatic intracranial hypertension in intensive care settings.

Functional Analysis of Lactobacillus rhamnosus GG Pili in Relation to Adhesion and Immunomodulatory Interactions with Intestinal Epithelial Cells

Abstract: Lactobacillus rhamnosus GG, a probiotic with good survival capacity in the human gut, has well-documented adhesion properties and health effects. Recently, spaCBA-encoded pili that bind to human intestinal mucus were identified on its cell surface. Here, we report on the phenotypic analysis of a spaCBA pilus knockout mutant in comparison with the wild type and other adhesin mutants. The SpaCBA pilus of L. rhamnosus GG showed to be key for efficient adherence to the Caco-2 intestinal epithelial cell (IEC) line and biofilm formation. Moreover, the spaCBA mutant induces an elevated level of interleukin-8 (IL-8) mRNA in Caco-2 cells compared to the wild type, possibly involving an interaction of lipoteichoic acid with Toll-like receptor 2. In contrast, an L. rhamnosus GG mutant without exopolysaccharides but with an increased exposure of pili leads to the reduced expression of IL-8. Using Transwells to partition bacteria from Caco-2 cells, IL-8 induction is blocked completely regardless of whether wild-type or mutant L. rhamnosus GG cells are used. Taken together, our data suggest that L. rhamnosus GG SpaCBA pili, while promoting strong adhesive interactions with IECs, have a functional role in balancing IL-8 mRNA expression induced by surface molecules such as lipoteichoic acid.