Institution
University of Barcelona
Education•Barcelona, Spain•
About: University of Barcelona is a education organization based out in Barcelona, Spain. It is known for research contribution in the topics: Population & Transplantation. The organization has 46197 authors who have published 108576 publications receiving 3723377 citations. The organization is also known as: Universitat de Barcelona & UB.
Topics: Population, Transplantation, Medicine, Context (language use), Catalysis
Papers published on a yearly basis
Papers
More filters
••
Seconda Università degli Studi di Napoli1, University of Graz2, University of Rome Tor Vergata3, University of Vienna4, University of Naples Federico II5, University of Regensburg6, University of Sydney7, University of L'Aquila8, University of Miami9, University of Ljubljana10, University of Tübingen11, University of Geneva12, University of Buenos Aires13, University of Florence14, Medical College of Wisconsin15, University of Connecticut16, Memorial Sloan Kettering Cancer Center17, Cornell University18, University of Lübeck19, University of Barcelona20, University of Siena21, Rutgers University22, Shinshu University23, University of Modena and Reggio Emilia24, Keio University25, Ludwig Maximilian University of Munich26, New York University27
TL;DR: The virtual Consensus Net Meeting on Dermoscopy represents a valid tool for better standardization of the dermoscopic terminology and, moreover, opens up a new territory for diagnosing and managing pigmented skin lesions.
Abstract: Background: There is a need for better standardization of the dermoscopic terminology in assessing pigmented skin lesions. Objective: The virtual Consensus Net Meeting on Dermoscopy was organized to investigate reproducibility and validity of the various features and diagnostic algorithms. Methods: Dermoscopic images of 108 lesions were evaluated via the Internet by 40 experienced dermoscopists using a 2-step diagnostic procedure. The first-step algorithm distinguished melanocytic versus nonmelanocytic lesions. The second step in the diagnostic procedure used 4 algorithms (pattern analysis, ABCD rule, Menzies method, and 7-point checklist) to distinguish melanoma versus benign melanocytic lesions. κ Values, log odds ratios, sensitivity, specificity, and positive likelihood ratios were estimated for all diagnostic algorithms and dermoscopic features. Results: Interobserver agreement was fair to good for all diagnostic methods, but it was poor for the majority of dermoscopic criteria. Intraobserver agreement was good to excellent for all algorithms and features considered. Pattern analysis allowed the best diagnostic performance (positive likelihood ratio: 5.1), whereas alternative algorithms revealed comparable sensitivity but less specificity. Interobserver agreement on management decisions made by dermoscopy was fairly good (mean κ value: 0.53). Conclusion: The virtual Consensus Net Meeting on Dermoscopy represents a valid tool for better standardization of the dermoscopic terminology and, moreover, opens up a new territory for diagnosing and managing pigmented skin lesions. (J Am Acad Dermatol 2003;48:679-93.) J Am Acad Dermatol 2003;48:679-93.
971 citations
••
TL;DR: This work provides the first comprehensive catalog of somatic mutations in CLL with relevant clinical correlates and defines a large set of new genes that may drive the development of this common form of leukemia.
Abstract: Here we perform whole-exome sequencing of samples from 105 individuals with chronic lymphocytic leukemia (CLL), the most frequent leukemia in adults in Western countries. We found 1,246 somatic mutations potentially affecting gene function and identified 78 genes with predicted functional alterations in more than one tumor sample. Among these genes, SF3B1, encoding a subunit of the spliceosomal U2 small nuclear ribonucleoprotein (snRNP), is somatically mutated in 9.7% of affected individuals. Further analysis in 279 individuals with CLL showed that SF3B1 mutations were associated with faster disease progression and poor overall survival. This work provides the first comprehensive catalog of somatic mutations in CLL with relevant clinical correlates and defines a large set of new genes that may drive the development of this common form of leukemia. The results reinforce the idea that targeting several well-known genetic pathways, including mRNA splicing, could be useful in the treatment of CLL and other malignancies.
969 citations
••
TL;DR: To overcome the complexity of genomic aberrations in HCC, combination therapies will be critical and a molecular classification of HCC based on genome‐wide investigations and identification of patient subclasses according to drug responsiveness will lead to a more personalized medicine.
969 citations
••
TL;DR: In this paper, the authors presented new determinations of the cosmic expansion history from red-envelope galaxies using the Keck-LRIS spectrograph of 24 galaxy clusters in the redshift range 0.2 < z < 1.0.
Abstract: We present new determinations of the cosmic expansion history from red-envelope galaxies. We have obtained for this purpose high-quality spectra with the Keck-LRIS spectrograph of red-envelope galaxies in 24 galaxy clusters in the redshift range 0.2 < z < 1.0. We complement these Keck spectra with high-quality, publicly available archival spectra from the SPICES and VVDS surveys. We improve over our previous expansion history measurements in Simon et al. (2005) by providing two new determinations of the expansion history: H(z) = 97±62 km sec^(−1) Mpc^(−1) at z ≃ 0.5 and H(z) = 90±40 km sec^(−1) Mpc^(−1) at z ≃ 0.9. We discuss the uncertainty in the expansion history determination that arises from uncertainties in the synthetic stellar-population models. We then use these new measurements in concert with cosmic-microwave-background (CMB) measurements to constrain cosmological parameters, with a special emphasis on dark-energy parameters and constraints to the curvature. In particular, we demonstrate the usefulness of direct H(z) measurements by constraining the dark-energy equation of state parameterized by w_0 and w_a and allowing for arbitrary curvature. Further, we also constrain, using only CMB and H(z) data, the number of relativistic degrees of freedom to be 4±0.5 and their total mass to be < 0.2 eV, both at 1σ.
966 citations
••
William F. Laurance1, William F. Laurance2, D. Carolina Useche2, Julio Rendeiro2 +213 more•Institutions (101)
TL;DR: These findings suggest that tropical protected areas are often intimately linked ecologically to their surrounding habitats, and that a failure to stem broad-scale loss and degradation of such habitats could sharply increase the likelihood of serious biodiversity declines.
Abstract: The rapid disruption of tropical forests probably imperils global biodiversity more than any other contemporary phenomenon(1-3). With deforestation advancing quickly, protected areas are increasingly becoming final refuges for threatened species and natural ecosystem processes. However, many protected areas in the tropics are themselves vulnerable to human encroachment and other environmental stresses(4-9). As pressures mount, it is vital to know whether existing reserves can sustain their biodiversity. A critical constraint in addressing this question has been that data describing a broad array of biodiversity groups have been unavailable for a sufficiently large and representative sample of reserves. Here we present a uniquely comprehensive data set on changes over the past 20 to 30 years in 31 functional groups of species and 21 potential drivers of environmental change, for 60 protected areas stratified across the world's major tropical regions. Our analysis reveals great variation in reserve 'health': about half of all reserves have been effective or performed passably, but the rest are experiencing an erosion of biodiversity that is often alarmingly widespread taxonomically and functionally. Habitat disruption, hunting and forest-product exploitation were the strongest predictors of declining reserve health. Crucially, environmental changes immediately outside reserves seemed nearly as important as those inside in determining their ecological fate, with changes inside reserves strongly mirroring those occurring around them. These findings suggest that tropical protected areas are often intimately linked ecologically to their surrounding habitats, and that a failure to stem broad-scale loss and degradation of such habitats could sharply increase the likelihood of serious biodiversity declines.
962 citations
Authors
Showing all 46622 results
Name | H-index | Papers | Citations |
---|---|---|---|
Joan Massagué | 189 | 408 | 149951 |
Michael Snyder | 169 | 840 | 130225 |
Michael R. Stratton | 161 | 443 | 142586 |
Johan Auwerx | 158 | 653 | 95779 |
Bart Staels | 152 | 824 | 86638 |
David D'Enterria | 150 | 1592 | 116210 |
Thomas E. Starzl | 150 | 1625 | 91704 |
Manel Esteller | 146 | 713 | 96429 |
Peter B. Jones | 145 | 1857 | 94641 |
Carlos Cordon-Cardo | 144 | 589 | 84862 |
Kjell Fuxe | 142 | 1479 | 89846 |
Kenneth M. Yamada | 139 | 446 | 72136 |
John G.F. Cleland | 137 | 1172 | 110227 |
António Amorim | 136 | 1477 | 96519 |
Elias Campo | 135 | 761 | 85160 |