University of Cambridge

About: University of Cambridge is a education organization based out in Cambridge, United Kingdom. It is known for research contribution in the topics: Population & Galaxy. The organization has 118293 authors who have published 282289 publications receiving 14497093 citations. The organization is also known as: Cambridge University & Cambridge.

Remyelination in the CNS: from biology to therapy

Abstract: Remyelination involves reinvesting demyelinated axons with new myelin sheaths. In stark contrast to the situation that follows loss of neurons or axonal damage, remyelination in the CNS can be a highly effective regenerative process. It is mediated by a population of precursor cells called oligodendrocyte precursor cells (OPCs), which are widely distributed throughout the adult CNS. However, despite its efficiency in experimental models and in some clinical diseases, remyelination is often inadequate in demyelinating diseases such as multiple sclerosis (MS), the most common demyelinating disease and a cause of neurological disability in young adults. The failure of remyelination has profound consequences for the health of axons, the progressive and irreversible loss of which accounts for the progressive nature of these diseases. The mechanisms of remyelination therefore provide critical clues for regeneration biologists that help them to determine why remyelination fails in MS and in other demyelinating diseases and how it might be enhanced therapeutically.

Central cholinergic systems and cognition

Abstract: The organization and possible functions of basal forebrain and pontine cholinergic systems are reviewed. Whereas the basal forebrain cholinergic neuronal projections likely subserve a common electrophysiological function, e.g. to boost signal-to-noise ratios in cortical target areas, this function has different effects on psychological processes dependent upon the neural network operations within these various cortical domains. Evidence is presented that (a) the nucleus basalis-neocortical cholinergic system contributes greatly to visual attentional function, but not to mnemonic processes per se; (b) the septohippocampal projection is involved in the modulation of short-term spatial (working) memory processes, perhaps by prolonging the neural representation of external stimuli within the hippocampus; and (c) the diagonal band-cingulate cortex cholinergic projection impacts on the ability to utilize response rules through conditional discrimination. We also suggest that nucleus basalis-amygdala cholinergic projections have a role in the retention of affective conditioning while brainstem cholinergic projections to the thalamus and midbrain dopamine neurons affect basic arousal processes (e.g. sleep-wake cycle) and behavioral activation, respectively. The possibilities and limitations of therapeutic interventions with procholinergic drugs in patients with Alzheimer's disease and other neurodegenerative disorders in which basal forebrain cholinergic neurons degenerate are also discussed.

World Alzheimer Report 2015 - The Global Impact of Dementia: An analysis of prevalence, incidence, cost and trends

Abstract: for which we are very grateful. All the authors and investigators of dementia studies who provided us more specific data from their work. foreword Today, over 46 million people live with dementia worldwide, more than the population of Spain. This number is estimated to increase to 131.5 million by 2050. Dementia also has a huge economic impact. Today, the total estimated worldwide cost of dementia is US $818 billion, and it will become a trillion dollar disease by 2018. This means that if dementia care were a country, it would be the world's 18th largest economy, more than the market values of companies such as Apple (US$ 742 billion), Google (US$ 368 billion) and Exxon (US$ 357 billion). In many parts of the world, there is a growing awareness of dementia, but across the globe it remains the case that a diagnosis of dementia can bring with it stigma and social isolation. Today, we estimate that 94% of people living with dementia in low and middle income countries are cared for at home. These are regions where health and care systems often provide limited or no support to people living with dementia or to their families. The 2015 World Alzheimer Report updates data on the prevalence, incidence, cost and trends of dementia worldwide. It also estimates how these numbers will increase in the future, leaving us with no doubt that dementia, including Alzheimer's disease and other causes, is one of the biggest global public health and social care challenges facing people today and in the future. The two organisations we lead are ADI, the only worldwide federation of Alzheimer associations and global voice on dementia, and Bupa, a purpose-driven global health and care company that is the leading international provider of specialist dementia care, caring for around 60,000 people living with dementia each year. Together, we are committed to ensuring that dementia becomes an international health priority. We believe national dementia plans are the first step towards ensuring all countries are equipped to enable people to live well with dementia, and help to reduce the risk of dementia for future generations. There is now a growing list of countries which have such provision in place or which are developing national dementia plans, but it's not enough. Given the epidemic scale of dementia, with no known cure on the horizon, and with a global ageing population, we're calling on governments and …

A dwarf satellite galaxy in Sagittarius

Abstract: WE have detected a large, extended group of comoving stars in the direction of the Galactic Centre, which we interpret as belonging to a dwarf galaxy that is closer to our own Galaxy than any other yet known. Located in the constellation of Sagittarius, and on the far side of the Galactic Centre, it has not previously been seen because of the large number of foreground stars (in the Milky Way) in that direction. Following convention, we propose to call it the Sagittarius dwarf galaxy. Its properties are similar to those of the eight other dwarf spheroidal companions to the Milky Way, and it is comparable in size and luminosity to the largest of them— the Fornax system. The Sagittarius dwarf is elongated towards the plane of the Milky Way, suggesting that it is undergoing some tidal disruption before being absorbed by the Milky Way.

High-redshift star formation in the Hubble Deep Field revealed by a submillimetre-wavelength survey

Abstract: In the local Universe, most galaxies are dominated by stars, with less than ten per cent of their visible mass in the form of gas. Determining when most of these stars formed is one of the central issues of observational cosmology. Optical and ultraviolet observations of high-redshift galaxies (particularly those in the Hubble Deep Field) have been interpreted as indicating that the peak of star formation occurred between redshifts of 1 and 1.5. But it is known that star formation takes place in dense clouds, and is often hidden at optical wavelengths because of extinction by dust in the clouds. Here we report a deep submillimetre-wavelength survey of the Hubble Deep Field; these wavelengths trace directly the emission from dust that has been warmed by massive star-formation activity. The combined radiation of the five most significant detections accounts for 30–50 per cent of the previously unresolved background emission in this area. Four of these sources appear to be galaxies in the redshift range 2< z < 4, which, assuming these objects have properties comparable to local dust-enshrouded starburst galaxies, implies a star-formation rate during that period about a factor of five higher than that inferred from the optical and ultraviolet observations.