University of Cambridge

About: University of Cambridge is a education organization based out in Cambridge, United Kingdom. It is known for research contribution in the topics: Population & Galaxy. The organization has 118293 authors who have published 282289 publications receiving 14497093 citations. The organization is also known as: Cambridge University & Cambridge.

Retinoblastoma protein recruits histone deacetylase to repress transcription

Abstract: The retinoblastoma protein (Rb) silences specific genes that are active in the S phase of the cell cycle and which are regulated by E2F transcription factors Rb binds to the activation domain of E2F and then actively represses the promoter by a mechanism that is poorly understood Here we show that Rb associates with a histone deacetylase, HDAC1, through the Rb 'pocket' domain Association with the deacetylase is reduced by naturally occurring mutations in the pocket and by binding of the human papilloma virus oncoprotein E7 We find that Rb can recruit histone deacetylase to E2F and that Rb cooperates with HDAC1 to repress the E2F-regulated promoter of the gene encoding the cell-cycle protein cyclin E Inhibition of histone deacetylase activity by trichostatin A (TSA) inhibits Rb-mediated repression of a chromosomally integrated E2F-regulated promoter Our results indicate that histone deacetylases are important for regulating the cell cycle and that active transcriptional repression by Rb may involve the modification of chromatin structure

Unsteady outflow models for cosmological gamma-ray bursts

Abstract: The 'event' that triggers a gamma-ray burst cannot last for more than a few seconds. This is, however, long compared with the dynamical timescale of a compact stellar-mass object (approximately 10 (exp-3) s). Energy is assumed to be released as an outflow with high mean Lorentz factor Gamma. But a compact stellar-mass collapse or merger is, realistically, likely to generate a mass (or energy) flux that is unsteady on some timescales in the range 10(exp -3) - 10 s. If Gamma fluctuates by a factor of approximately 2 around its mean value, relative motions within the outflowing material will themselves (in the comoving frame) be relativistic, and can give rise to internal shocks. For Gamma approximately 10(exp 2), the resultant dissipation occurs outside the 'photosphere' and can convert a substantial fraction of the overall outflow energy into nonthermal radiation. This suggests a mechanism for cosmological bursts that demands less extreme assumptions (in respect of Gamma-values, freedom from baryonic contamination, etc.) than earlier proposals.

Neural population dynamics during reaching

Abstract: Most theories of motor cortex have assumed that neural activity represents movement parameters. This view derives from what is known about primary visual cortex, where neural activity represents patterns of light. Yet it is unclear how well the analogy between motor and visual cortex holds. Single-neuron responses in motor cortex are complex, and there is marked disagreement regarding which movement parameters are represented. A better analogy might be with other motor systems, where a common principle is rhythmic neural activity. Here we find that motor cortex responses during reaching contain a brief but strong oscillatory component, something quite unexpected for a non-periodic behaviour. Oscillation amplitude and phase followed naturally from the preparatory state, suggesting a mechanistic role for preparatory neural activity. These results demonstrate an unexpected yet surprisingly simple structure in the population response. This underlying structure explains many of the confusing features of individual neural responses.

Experimental Realization of Teleporting an Unknown Pure Quantum State via Dual Classical and Einstein-Podolsky-Rosen Channels

Abstract: We report on a quantum optical experimental implementation of teleportation of unknown pure quantum states. This realizes all of the nonlocal aspects of the original scheme proposed by Bennett et al. and is equivalent to it up to a local operation. We exhibit results for the teleportation of a linearly polarized state and of an elliptically polarized state. We show that the experimental results cannot be explained in terms of a classical channel alone. The Bell measurement in our experiment can distinguish between all four Bell states simultaneously allowing, in the ideal case, a 100% success rate of teleportation. [S0031-9007(97)05275-7]