Institution
University of Cambridge
Education•Cambridge, United Kingdom•
About: University of Cambridge is a education organization based out in Cambridge, United Kingdom. It is known for research contribution in the topics: Population & Galaxy. The organization has 118293 authors who have published 282289 publications receiving 14497093 citations. The organization is also known as: Cambridge University & Cambridge.
Topics: Population, Galaxy, Context (language use), Gene, Transplantation
Papers published on a yearly basis
Papers
More filters
••
TL;DR: This study sequence 173 genes in 2,433 primary breast tumours that have copy number aberration, gene expression and long-term clinical follow-up data, and determines associations between mutations, driver CNA profiles, clinical-pathological parameters and survival.
Abstract: The genomic landscape of breast cancer is complex, and inter- and intra-tumour heterogeneity are important challenges in treating the disease. In this study, we sequence 173 genes in 2,433 primary breast tumours that have copy number aberration (CNA), gene expression and long-term clinical follow-up data. We identify 40 mutation-driver (Mut-driver) genes, and determine associations between mutations, driver CNA profiles, clinical-pathological parameters and survival. We assess the clonal states of Mut-driver mutations, and estimate levels of intra-tumour heterogeneity using mutant-allele fractions. Associations between PIK3CA mutations and reduced survival are identified in three subgroups of ER-positive cancer (defined by amplification of 17q23, 11q13–14 or 8q24). High levels of intra-tumour heterogeneity are in general associated with a worse outcome, but highly aggressive tumours with 11q13–14 amplification have low levels of intra-tumour heterogeneity. These results emphasize the importance of genome-based stratification of breast cancer, and have important implications for designing therapeutic strategies.
1,205 citations
••
TL;DR: The main factors — including models of the allelic architecture of common diseases, sample size, map density and sample-collection biases — that need to be taken into account in order to optimize the cost efficiency of identifying genuine disease-susceptibility loci are outlined.
Abstract: To fully understand the allelic variation that underlies common diseases, complete genome sequencing for many individuals with and without disease is required. This is still not technically feasible. However, recently it has become possible to carry out partial surveys of the genome by genotyping large numbers of common SNPs in genome-wide association studies. Here, we outline the main factors - including models of the allelic architecture of common diseases, sample size, map density and sample-collection biases - that need to be taken into account in order to optimize the cost efficiency of identifying genuine disease-susceptibility loci.
1,204 citations
••
TL;DR: The origins and effects of loss in turbomachines are discussed in this article with the emphasis on trying to understand the physical origins of loss rather than on reviewing the available prediction methods.
Abstract: The origins and effects of loss in turbomachines are discussed with the emphasis on trying to understand the physical origins of loss rather than on reviewing the available prediction methods. Loss is defined in terms of entropy increase and the relationship of this to the more familiar loss coefficients is derived and discussed. The sources of entropy are, in general: viscous effects in boundary layers, viscous effects in mixing processes, shock waves, and heat transfer across temperature differences. These are first discussed in general and then the results are applied to turbomachinery flows. Understanding of the loss due to heat transfer requires some discussion of cycle thermodynamics
1,203 citations
••
TL;DR: In this paper, the authors examine the differences between covalent random networks with high and low average coordination and make rigorous assumptions about the number of continuous deformations (i.e., zero frequency modes) allowed within the network.
Abstract: We examine some current ideas concerning the differences between covalent random networks with high and low average coordination. These ideas can be made rigorous by considering the number of continuous deformations (i.e. zero frequency modes) allowed within the network. In the transition from one kind of network to another, rigidity percolates through the system. This leads to a picture in which random networks with low average coordination (polymeric glasses) have large floppy or spongy regions with a few rigid inclusions. On the other hand in random networks with high average coordination (amorphous solids) the rigid regions have percolated to form a rigid solid with a few floppy or spongy inclusions.
1,202 citations
••
TL;DR: The analysis of the behavioural and neural mechanisms of reinforcement and motivation has benefited from the recent application of learning theory and better anatomical knowledge of the connectivity of certain key neural structures, such as the nucleus accumbens.
1,200 citations
Authors
Showing all 119522 results
Name | H-index | Papers | Citations |
---|---|---|---|
Albert Hofman | 267 | 2530 | 321405 |
Zhong Lin Wang | 245 | 2529 | 259003 |
Solomon H. Snyder | 232 | 1222 | 200444 |
Trevor W. Robbins | 231 | 1137 | 164437 |
George Davey Smith | 224 | 2540 | 248373 |
Nicholas J. Wareham | 212 | 1657 | 204896 |
Cyrus Cooper | 204 | 1869 | 206782 |
Eric B. Rimm | 196 | 988 | 147119 |
Martin White | 196 | 2038 | 232387 |
Simon D. M. White | 189 | 795 | 231645 |
Michael Rutter | 188 | 676 | 151592 |
George Efstathiou | 187 | 637 | 156228 |
Mark Hallett | 186 | 1170 | 123741 |
David H. Weinberg | 183 | 700 | 171424 |
Paul G. Richardson | 183 | 1533 | 155912 |