University of Cambridge

About: University of Cambridge is a education organization based out in Cambridge, United Kingdom. It is known for research contribution in the topics: Population & Galaxy. The organization has 118293 authors who have published 282289 publications receiving 14497093 citations. The organization is also known as: Cambridge University & Cambridge.

Notch signalling: a simple pathway becomes complex

Abstract: A small number of signalling pathways are used iteratively to regulate cell fates, cell proliferation and cell death in development. Notch is the receptor in one such pathway, and is unusual in that most of its ligands are also transmembrane proteins; therefore signalling is restricted to neighbouring cells. Although the intracellular transduction of the Notch signal is remarkably simple, with no secondary messengers, this pathway functions in an enormous diversity of developmental processes and its dysfunction is implicated in many cancers.

The mechanism of eukaryotic translation initiation and principles of its regulation

Abstract: Protein synthesis is principally regulated at the initiation stage (rather than during elongation or termination), allowing rapid, reversible and spatial control of gene expression. Progress over recent years in determining the structures and activities of initiation factors, and in mapping their interactions in ribosomal initiation complexes, have advanced our understanding of the complex translation initiation process. These developments have provided a solid foundation for studying the regulation of translation initiation by mechanisms that include the modulation of initiation factor activity (which affects almost all scanning-dependent initiation) and through sequence-specific RNA-binding proteins and microRNAs (which affect individual mRNAs).

How iris recognition works

Abstract: The principle that underlies the recognition of persons by their iris patterns is the failure of a test of statistical independence on texture phase structure as encoded by multiscale quadrature wavelets. The combinatorial complexity of this phase information across different persons spans about 249 degrees of freedom and generates a discrimination entropy of about 3.2 bits/mm/sup 2/ over the iris, enabling real-time decisions about personal identity with extremely high confidence. Algorithms first described by the author in 1993 have now been tested in several independent field trials and are becoming widely licensed. This presentation reviews how the algorithms work and presents the results of 9.1 million comparisons among different eye images acquired in trials in Britain, the USA, Korea, and Japan.