scispace - formally typeset
Search or ask a question

Showing papers by "University of Colorado Boulder published in 1998"


Journal ArticleDOI
TL;DR: In this article, a step-by-step guide to wavelet analysis is given, with examples taken from time series of the El Nino-Southern Oscillation (ENSO).
Abstract: A practical step-by-step guide to wavelet analysis is given, with examples taken from time series of the El Nino–Southern Oscillation (ENSO). The guide includes a comparison to the windowed Fourier transform, the choice of an appropriate wavelet basis function, edge effects due to finite-length time series, and the relationship between wavelet scale and Fourier frequency. New statistical significance tests for wavelet power spectra are developed by deriving theoretical wavelet spectra for white and red noise processes and using these to establish significance levels and confidence intervals. It is shown that smoothing in time or scale can be used to increase the confidence of the wavelet spectrum. Empirical formulas are given for the effect of smoothing on significance levels and confidence intervals. Extensions to wavelet analysis such as filtering, the power Hovmoller, cross-wavelet spectra, and coherence are described. The statistical significance tests are used to give a quantitative measure of change...

12,803 citations


Journal ArticleDOI
TL;DR: The adequacy of LSA's reflection of human knowledge has been established in a variety of ways, for example, its scores overlap those of humans on standard vocabulary and subject matter tests; it mimics human word sorting and category judgments; it simulates word‐word and passage‐word lexical priming data.
Abstract: Latent Semantic Analysis (LSA) is a theory and method for extracting and representing the contextual‐usage meaning of words by statistical computations applied to a large corpus of text (Landauer & Dumais, 1997). The underlying idea is that the aggregate of all the word contexts in which a given word does and does not appear provides a set of mutual constraints that largely determines the similarity of meaning of words and sets of words to each other. The adequacy of LSA's reflection of human knowledge has been established in a variety of ways. For example, its scores overlap those of humans on standard vocabulary and subject matter tests; it mimics human word sorting and category judgments; it simulates word‐word and passage‐word lexical priming data; and, as reported in 3 following articles in this issue, it accurately estimates passage coherence, learnability of passages by individual students, and the quality and quantity of knowledge contained in an essay.

4,391 citations


Journal ArticleDOI
TL;DR: Significantly better language development was associated with early identification of hearing loss and early intervention and the variable on which the two groups differed must be considered a potential explanation for the language advantage documented in the earlier-identified group.
Abstract: Objective. To compare the language abilities of earlier- and later-identified deaf and hard-of-hearing children. Method. We compared the receptive and expressive language abilities of 72 deaf or hard-of-hearing children whose hearing losses were identified by 6 months of age with 78 children whose hearing losses were identified after the age of 6 months. All of the children received early intervention services within an average of 2 months after identification. The participants9 receptive and expressive language abilities were measured using the Minnesota Child Development Inventory. Results. Children whose hearing losses were identified by 6 months of age demonstrated significantly better language scores than children identified after 6 months of age. For children with normal cognitive abilities, this language advantage was found across all test ages, communication modes, degrees of hearing loss, and socioeconomic strata. It also was independent of gender, minority status, and the presence or absence of additional disabilities. Conclusions. Significantly better language development was associated with early identification of hearing loss and early intervention. There was no significant difference between the earlier- and later-identified groups on several variables frequently associated with language ability in deaf and hard-of-hearing children. Thus, the variable on which the two groups differed (age of identification and intervention) must be considered a potential explanation for the language advantage documented in the earlier-identified group.

1,917 citations


Journal ArticleDOI
TL;DR: Recent declines in honeybee numbers in the United States and Europe bring home the importance of healthy pollination systems, and the need to further develop native bees and other animals as crop pollinators.
Abstract: ▪ Abstract The pollination of flowering plants by animals represents a critical ecosystem service of great value to humanity, both monetary and otherwise. However, the need for active conservation of pollination interactions is only now being appreciated. Pollination systems are under increasing threat from anthropogenic sources, including fragmentation of habitat, changes in land use, modern agricultural practices, use of chemicals such as pesticides and herbicides, and invasions of non-native plants and animals. Honeybees, which themselves are non-native pollinators on most continents, and which may harm native bees and other pollinators, are nonetheless critically important for crop pollination. Recent declines in honeybee numbers in the United States and Europe bring home the importance of healthy pollination systems, and the need to further develop native bees and other animals as crop pollinators. The “pollination crisis” that is evident in declines of honeybees and native bees, and in damage to web...

1,653 citations


Journal ArticleDOI
TL;DR: In this article, the authors propose a communication-based model of relationship marketing and discuss how communication is the foundation of the new customer-focused marketing efforts, rather than persuading.
Abstract: The authors propose a communication-based model of relationship marketing and discuss how communication (rather than persuasion) is the foundation of the “new” customer-focused marketing efforts. T...

1,263 citations


Journal ArticleDOI
TL;DR: A theory of task/technology fit in GSS environments based on attributes of task complexity and their relationship to relevant dimensions of GSS technology is developed.
Abstract: The characteristics of a group's task have been shown to account for more than half the variation in group interaction. In the context of group support systems (GSS), the importance of task has been underscored by the recommendation that achieving a fit between task and technology should be a principle for effective GSS use. Although the body of group support systems research has grown in recent years, and experience with different tasks and technologies now exists, no generally accepted theory of task/technology fit has emerged. This paper develops a theory of task/technology fit in GSS environments based on attributes of task complexity and their relationship to relevant dimensions of GSS technology. Propositions to guide further research are developed from the theory.

1,066 citations


Journal ArticleDOI
TL;DR: It is found that pairs (dimers) of aromatic side chain amino acids preferentially align their respective aromatic rings in an off-centered parallel orientation, which is referred to as parallel displaced pi-stacking and is consistent with ab initio and molecular mechanics calculations of benzene dimer.

1,025 citations


Posted Content
TL;DR: In this article, the authors proposed a model to predict relationships between affiliate sales and country characteristics, and then subject these predictions to empirical tests, showing that the model predicts relationships between the two properties.
Abstract: What we term the firm includes three principal assumptions. First, services of knowledge-based and knowledge-generating activities, such as R&D, can be geographically separated from production and supplied to production facilities at low cost. Second, these knowledge-intensive activities are skilled-labor intensive relative to production. These characteristics give rise to vertical multinationals, which fragment production and locate activities according to factor prices and market size. Third, knowledge-based services have a (partial) joint-input characteristic that they can be supplied to additional production facilities at low cost. This characteristic gives rise to horizontal multinationals, which produce the same goods or services in multiple locations. In this paper, we note how this model predicts relationships between affiliate sales and country characteristics. We then subject these predictions to empirical tests.

999 citations


Journal ArticleDOI
08 May 1998-Science
TL;DR: Three biodemographic insights--concerning the correlation of death rates across age, individual differences in survival chances, and induced alterations in age patterns of fertility and mortality--offer clues and suggest research on the failure of complicated systems, on new demographic equations for evolutionary theory, and on fertility-longevity interactions.
Abstract: Old-age survival has increased substantially since 1950 Death rates decelerate with age for insects, worms, and yeast, as well as humans This evidence of extended postreproductive survival is puzzling Three biodemographic insights—concerning the correlation of death rates across age, individual differences in survival chances, and induced alterations in age patterns of fertility and mortality—offer clues and suggest research on the failure of complicated systems, on new demographic equations for evolutionary theory, and on fertility-longevity interactions Nongenetic changes account for increases in human life-spans to date Explication of these causes and the genetic license for extended survival, as well as discovery of genes and other survival attributes affecting longevity, will lead to even longer lives

974 citations


Journal ArticleDOI
TL;DR: In this article, the authors describe a Markov method for process discovery, as well as two additional methods that are adopted from other domains and augmented for their purposes, and compare the methods and discuss their application in an industrial case study.
Abstract: Many software process methods and tools presuppose the existence of a formal model of a process. Unfortunately, developing a formal model for an on-going, complex process can be difficult, costly, and error prone. This presents a practical barrier to the adoption of process technologies, which would be lowered by automated assistance in creating formal models. To this end, we have developed a data analysis technique that we term process discovery. Under this technique, data describing process events are first captured from an on-going process and then used to generate a formal model of the behavior of that process. In this article we describe a Markov method that we developed specifically for process discovery, as well as describe two additional methods that we adopted from other domains and augmented for our purposes. The three methods range from the purely algorithmic to the purely statistical. We compare the methods and discuss their application in an industrial case study.

962 citations


Journal ArticleDOI
TL;DR: In this article, the authors report on joint helioseismic analyses of solar rotation in the convection zone and in the outer part of the radiative core using the Michelson Doppler Imager (MDI) on the Solar and Heliospheric Observatory (SOHO) spacecraft.
Abstract: The splitting of the frequencies of the global resonant acoustic modes of the Sun by large-scale flows and rotation permits study of the variation of angular velocity Ω with both radius and latitude within the turbulent convection zone and the deeper radiative interior. The nearly uninterrupted Doppler imaging observations, provided by the Solar Oscillations Investigation (SOI) using the Michelson Doppler Imager (MDI) on the Solar and Heliospheric Observatory (SOHO) spacecraft positioned at the L1 Lagrangian point in continuous sunlight, yield oscillation power spectra with very high signal-to-noise ratios that allow frequency splittings to be determined with exceptional accuracy. This paper reports on joint helioseismic analyses of solar rotation in the convection zone and in the outer part of the radiative core. Inversions have been obtained for a medium-l mode set (involving modes of angular degree l extending to about 250) obtained from the first 144 day interval of SOI-MDI observations in 1996. Drawing inferences about the solar internal rotation from the splitting data is a subtle process. By applying more than one inversion technique to the data, we get some indication of what are the more robust and less robust features of our inversion solutions. Here we have used seven different inversion methods. To test the reliability and sensitivity of these methods, we have performed a set of controlled experiments utilizing artificial data. This gives us some confidence in the inferences we can draw from the real solar data. The inversions of SOI-MDI data have confirmed that the decrease of Ω with latitude seen at the surface extends with little radial variation through much of the convection zone, at the base of which is an adjustment layer, called the tachocline, leading to nearly uniform rotation deeper in the radiative interior. A prominent rotational shearing layer in which Ω increases just below the surface is discernible at low to mid latitudes. Using the new data, we have also been able to study the solar rotation closer to the poles than has been achieved in previous investigations. The data have revealed that the angular velocity is distinctly lower at high latitudes than the values previously extrapolated from measurements at lower latitudes based on surface Doppler observations and helioseismology. Furthermore, we have found some evidence near latitudes of 75° of a submerged polar jet which is rotating more rapidly than its immediate surroundings. Superposed on the relatively smooth latitudinal variation in Ω are alternating zonal bands of slightly faster and slower rotation, each extending some 10° to 15° in latitude. These relatively weak banded flows have been followed by inversion to a depth of about 5% of the solar radius and appear to coincide with the evolving pattern of torsional oscillations reported from earlier surface Doppler studies.

Journal ArticleDOI
TL;DR: In this paper, a model is constructed in which multinational firms arise endogenously, and it is shown that multinational firms are more important in total activity when countries are similar in incomes (size) and in relative factor endowments, and when total world income is high.

Journal ArticleDOI
TL;DR: It is demonstrated that the cross-spectral metric is optimal in the sense that it maximizes mutual information between the observed and desired processes and is capable of outperforming the more complex eigendecomposition-based methods.
Abstract: The Wiener filter is analyzed for stationary complex Gaussian signals from an information theoretic point of view. A dual-port analysis of the Wiener filter leads to a decomposition based on orthogonal projections and results in a new multistage method for implementing the Wiener filter using a nested chain of scalar Wiener filters. This new representation of the Wiener filter provides the capability to perform an information-theoretic analysis of previous, basis-dependent, reduced-rank Wiener filters. This analysis demonstrates that the cross-spectral metric is optimal in the sense that it maximizes mutual information between the observed and desired processes. A new reduced-rank Wiener filter is developed based on this new structure which evolves a basis using successive projections of the desired signal onto orthogonal, lower dimensional subspaces. The performance is evaluated using a comparative computer analysis model and it is demonstrated that the low-complexity multistage reduced-rank Wiener filter is capable of outperforming the more complex eigendecomposition-based methods.

01 Jul 1998
TL;DR: The Earth Gravitational Model 1996 (EGM96) as discussed by the authors was developed by the NASA Goddard Space Flight Center (GSFC), the National Imagery and Mapping Agency (NIMA), and The Ohio State University (OSU) to develop an improved spherical harmonic model of the Earth's gravitational potential.
Abstract: The NASA Goddard Space Flight Center (GSFC), the National Imagery and Mapping Agency (NIMA), and The Ohio State University (OSU) have collaborated to develop an improved spherical harmonic model of the Earth's gravitational potential to degree 360. The new model, Earth Gravitational Model 1996 (EGM96), incorporates improved surface gravity data, altimeter-derived gravity anomalies from ERS-1 and from the GEOSAT Geodetic Mission (GM), extensive satellite tracking data-including new data from Satellite Laser Ranging (SLR), the Global Postioning System (GPS), NASA's Tracking and Data Relay Satellite System (TDRSS), the French DORIS system, and the US Navy TRANET Doppler tracking system-as well as direct altimeter ranges from TOPEX/POSEIDON (T/P), ERS-1, and GEOSAT. The final solution blends a low-degree combination model to degree 70, a block-diagonal solution from degree 71 to 359, and a quadrature solution at degree 360. The model was used to compute geoid undulations accurate to better than one meter (with the exception of areas void of dense and accurate surface gravity data) and realize WGS84 as a true three-dimensional reference system. Additional results from the EGM96 solution include models of the dynamic ocean topography to degree 20 from T/P and ERS-1 together, and GEOSAT separately, and improved orbit determination for Earth-orbiting satellites.

Journal ArticleDOI
TL;DR: The approach for predicting coherence through reanalyzing sets of texts from 2 studies that manipulated the coherence of texts and assessed readers’ comprehension indicates that the method is able to predict the effect of text coherence on comprehension and is more effective than simple term‐term overlap measures.
Abstract: Latent Semantic Analysis (LSA) is used as a technique for measuring the coherence of texts. By comparing the vectors for 2 adjoining segments of text in a high‐dimensional semantic space, the method provides a characterization of the degree of semantic relatedness between the segments. We illustrate the approach for predicting coherence through reanalyzing sets of texts from 2 studies that manipulated the coherence of texts and assessed readers’ comprehension. The results indicate that the method is able to predict the effect of text coherence on comprehension and is more effective than simple term‐term overlap measures. In this manner, LSA can be applied as an automated method that produces coherence predictions similar to propositional modeling. We describe additional studies investigating the application of LSA to analyzing discourse structure and examine the potential of LSA as a psychological model of coherence effects in text comprehension.

Journal ArticleDOI
TL;DR: A new method for generating tunable degrees of alignment of macromolecules by addition of magnetically aligned Pf1 filamentous bacteriophage as a cosolute is introduced.
Abstract: Dipolar coupling interactions represent an extremely valuable source of long-range distance and angle information that was previously not available for solution structure determinations of macromolecules. This is because observation of these dipolar coupling data requires creating an anisotropic environment for the macromolecule. Here we introduce a new method for generating tunable degrees of alignment of macromolecules by addition of magnetically aligned Pf1 filamentous bacteriophage as a cosolute. This phage-induced alignment technique has been used to study 1H-1H, 1H-13C, and 1H-15N dipolar coupling interactions in a DNA duplex, an RNA hairpin and several proteins including thioredoxin and apo-calmodulin. The phage allow alignment of macromolecules over a wide range of temperature and solution conditions and thus represent a stable versatile method for generating partially aligned macromolecules in solution.

Journal ArticleDOI
TL;DR: The survey establishes a baseline assessment that was conducted by states as part of their first year of participation in a Maternal and Child Health Bureau grant on state systems for universal newborn hearing screening, assessment, and intervention.
Abstract: This study reports the results of a comprehensive survey of 16 states regarding the coordination and characteristics of universal newborn hearing screening, audiologic assessment, and intervention ...

Journal ArticleDOI
TL;DR: This paper considers the realistic situation where the fluid and structure subproblems have different resolution requirements and their computational domains have non-matching discrete interfaces, and addresses the proper discretization of the governing interface boundary conditions.

Journal Article
TL;DR: Retrospective data from sinus floor augmentation bone grafts was collected from 38 surgeons for 1007 sinus grafts that involved the placement of 2997 implants over a 10-year period, with the majority of the implants followed for 3 years or more postrestoration.
Abstract: Retrospective data from sinus floor augmentation bone grafts were collected from 38 surgeons for 1007 sinus grafts that involved the placement of 2997 implants over a 10-year period, with the majority of the implants followed for 3 years or more postrestoration. There were 229 implant failures reported. Various root-form implants and grafting modalities were used. A consensus conference was organized to evaluate the data and reach a consensus on optimal treatment protocols. The complete database demonstrated a 90.0% success rate for implants placed in sinus grafts with at least 3 years of function. Differences in grafting materials, implant surfaces, and timing protocols were statistically analyzed. However, the database was so multivariate and multifactorial that it was difficult to draw definitive conclusions; these must await controlled prospective studies. The consensus conference therefore developed and voted on multiple consensus statements derived by committee review for bone graft materials, type of implants, timing for implant placement, failure analysis, radiographic analysis, indications/contraindications, prosthetics, and nomenclature. Several consensus statements were obtained, the most significant being that the sinus graft should now be considered a highly predictable and effective therapeutic modality.

Journal ArticleDOI
TL;DR: The authors examined the full range of past natural drought variability, deduced from a com- prehensive review of the paleoclimatic literature, suggests that droughts more severe than those of the 1930s and 1950s are likely to occur in the future, a likelihood that might be exacerbated by greenhouse warming in the next century.
Abstract: Droughts are one of the most devastating natural hazards faced by the United States today. Severe droughts of the twentieth century have had large impacts on economies, society, and the environment, especially in the Great Plains. However, the instrumental record of the last 100 years contains only a limited subset of drought realizations. One must turn to the paleoclimatic record to examine the full range of past drought variability, including the range of mag- nitude and duration, and thus gain the improved understanding needed for society to anticipate and plan for droughts of the future. Historical documents, tree rings, archaeological remains, lake sediment, and geomorphic data make it clear that the droughts of the twentieth century, including those of the 1930s and 1950s, were eclipsed several times by droughts earlier in the last 2000 years, and as recently as the late sixteenth century. In general, some droughts prior to 1600 appear to be characterized by longer duration (i.e., multidecadal) and greater spatial extent than those of the twentieth century. The authors' assessment of the full range of past natural drought variability, deduced from a com- prehensive review of the paleoclimatic literature, suggests that droughts more severe than those of the 1930s and 1950s are likely to occur in the future, a likelihood that might be exacerbated by greenhouse warming in the next century. Persistence conditions that lead to decadal-scale drought may be related to low-frequency variations, or base-state shifts, in both the Pacific and Atlantic Oceans, although more research is needed to understand the mechanisms of severe drought.

Journal ArticleDOI
01 Mar 1998-Chest
TL;DR: Autofluorescence bronchoscopy, when used as an adjunct to standard WLB, enhances the bronchoscopeopist's ability to localize small neoplastic lesions, especially intraepithelial lesions that may have significant implication in the management of lung cancer in the future.

Proceedings ArticleDOI
01 Nov 1998
TL;DR: An integrative review of the evolution of operational tra=formation techniques, with the go~ of identifying the major is-m, dgotiths, achievements, and remaining Mlenges, and a new optimized generic operational transformation control algorithm.
Abstract: Rd-time group editors dow a group of users to view and edit, the same document at the same time horn geograpbicdy di.~ersed sites connected by communication networks. Consistency maintenance is one of the most si@cant &alwiges in the design and implementation of thwe types of systems. R=earch on rd-time group editors in the past decade has invented au inuolative tetique for consistency maintenance, ded operational transformation This paper presents an integrative review of the evolution of operational tra=formation techniques, with the go~ of identifying the major is-m~s, dgotiths, achievements, and remaining Mlenges. In addition, this paper contribut= a new optimized generic operational transformation control algorithm. Ke~vords Consistency maint enauce, operational transformation, convergence, CauS*ty pras~ation, intention pre~tion, group e&tors, groupware, distributed computing.

Journal ArticleDOI
TL;DR: In this paper, a measure of consumers' attitude toward private label brands is developed, and its psychometric properties are assessed, and predictions are then tested regarding relationships between private label attitude and latent perceptual and sales promotion constructs, and purchase behaviors measured in a field setting.
Abstract: A measure of consumers’ attitude toward private label brands is developed, and its psychometric properties are assessed. Predictions are then tested regarding relationships between private label attitude and (1) latent perceptual and sales promotion constructs, and (2) purchase behaviors measured in a field setting. The measure is positively related to value consciousness, deal proneness, and smart-shopper self-perceptions, and negatively related to the propensity to be brand loyal and hold price-quality perceptions. Predictive validity of the private label measure is supported by a positive relationship with private label purchases from a grocery store shopping trip. Despite a positive relationship between the latent constructs of private label attitude and deal proneness, the consumer segment that allocated a high percentage of total purchases to private label products made fewer purchases on sale or with a coupon. These findings suggest that consumers may choose between price-related deals and private label purchases.

Journal ArticleDOI
TL;DR: In this paper, large-scale features of circulation, temperature, and precipitation appear in the simulations from the NCAR Community Climate Model Version 1 (CCM 1), and the implications of the simulated climate for the past continental-scale distributions of three plant taxa (Picea spp., Pseudotsuga menziesii, and Artemisia tridentata) are discussed.

Journal ArticleDOI
TL;DR: In this article, a new algorithm for modeling radiative transfer in inhomogeneous three-dimensional media is described, which uses a spherical harmonic angular representation to reduce memory use and time computing the source function.
Abstract: A new algorithm for modeling radiative transfer in inhomogeneous three-dimensional media is described. The spherical harmonics discrete ordinate method uses a spherical harmonic angular representation to reduce memory use and time computing the source function. The radiative transfer equation is integrated along discrete ordinates through a spatial grid to model the streaming of radiation. An adaptive grid approach, which places additional points where they are most needed to improve accuracy, is implemented. The solution method is a type of successive order of scattering approach or Picard iteration. The model computes accurate radiances or fluxes in either the shortwave or longwave regions, even for highly peaked phase functions. Broadband radiative transfer is computed efficiently with a k distribution. The results of validation tests and examples illustrating the efficiency and accuracy of the algorithm are shown for simple geometries and realistic simulated clouds.

Journal ArticleDOI
TL;DR: It is concluded that central, but not peripheral, arterial stiffness increases with age in sedentary healthy females in the absence of age-related increases in arterial blood pressure and aerobic fitness and plasma total cholesterol and LDL-cholesterol levels are significant independent physiological correlates of central arterials stiffness in this population.
Abstract: —Increased arterial stiffness is thought to contribute to the increased incidence of cardiovascular disease with age. Little, however, is known about the influence of aging on central and peripheral arterial stiffness in females. Moreover, it is unknown whether physical activity status influences age-related increases in arterial stiffness in females. Arterial pulse wave velocity (PWV) and augmentation index (AI, applanation tonometry) were measured in 53 healthy females, including 10 premenopausal (Pre-S) and 18 postmenopausal (Post-S) sedentary women, and 9 premenopausal (Pre-PA) and 16 postmenopausal (Post-PA) physically active women. In the sedentary women, there were no age-related differences in arterial blood pressure, but aortic PWV and carotid AI (measures of central arterial stiffness) were higher ( P <.01) in Post-S versus Pre-S (1065±110 versus 690±80 cm/sec and 16.5%±1.8% versus 0.3%±1.6%, respectively); however, there were no significant differences in leg and arm PWV (measures of peripheral arterial stiffness). Systolic and mean arterial blood pressures were higher ( P <.05) in Post-PA versus Pre-PA. Despite this and in contrast to the sedentary women, aortic PWV and AI were not different in Post-PA versus Pre-PA. Stepwise multiple regression indicated that maximal oxygen consumption, plasma total cholesterol, and plasma LDL-cholesterol were significant independent predictors and together explained up to 50% of the variability in central arterial stiffness. We concluded that (1) central, but not peripheral, arterial stiffness increases with age in sedentary healthy females in the absence of age-related increases in arterial blood pressure; (2) significant age-related increases in central arterial stiffness are not observed in highly physically active women; and (3) aerobic fitness and plasma total cholesterol and LDL-cholesterol levels are significant independent physiological correlates of central arterial stiffness in this population.

Journal ArticleDOI
TL;DR: In this paper, a survey of recent developments in the analysis of cointegrating vector autoregressions (VARs) to examine their links to the older structural modelling traditions using Autoregressive Distributed Lag (ARDL), and Simultaneous Equations Models (SEMs).
Abstract: This survey uses a number of recent developments in the analysis of cointegrating Vector Autoregressions (VARs) to examine their links to the older structural modelling traditions using Autoregressive Distributed Lag (ARDL), and Simultaneous Equations Models (SEMs). In particular, it emphasizes the importance of using judgement and economic theory to supplement the statistical information. After a brief historical review it sets out the statistical framework, discusses the identification of impulse responses using the Generalized Impulse Response functions, reviews the analysis of cointegrating VARs and highlights the large number of choices applied workers have to make in determining a specification. In particular, it considers the problem of specification of intercepts and trends and the size of the VAR in more detail, and examines the advantages of the use of exogenous variables in cointegration analysis. The issues are illustrated with a small U.S. Macroeconomic model.

Journal ArticleDOI
TL;DR: In this article, a simple stochastically forced, one-dimensional, linear, coupled energy balance model is proposed to quantify the effects of coupling between the atmosphere and ocean in the midlatitudes.
Abstract: Starting from the assumption that the atmosphere is the primary source of variability internal to the midlatitude atmosphere–ocean system on intraseasonal to interannual timescales, the authors construct a simple stochastically forced, one-dimensional, linear, coupled energy balance model. The coupled system is then dissected into partially coupled and uncoupled systems in order to quantify the effects of coupling. The simplicity of the model allows for analytic evaluation of many quantities of interest, including power spectra, total variance, lag covariance between atmosphere and ocean, and surface flux spectra. The model predicts that coupling between the atmosphere and ocean in the midlatitudes will enhance the variance in both media and will decrease the energy flux between the atmosphere and the ocean. The model also demonstrates that specification of historical midlatitude sea surface temperature anomalies as a boundary condition for an atmospheric model will not generally lead to a correc...

Journal ArticleDOI
TL;DR: Structural comparisons of the dsRBD‐dsRNA complex and models proposed for polynucleotidyl transferase‐nucleic acid complexes suggest that similarities in nucleic acid binding also exist between these families of proteins.
Abstract: Protein interactions with double-stranded RNA (dsRNA) are critical for many cell processes; however, in contrast to protein-dsDNA interactions, surprisingly little is known about the molecular basis of protein-dsRNA interactions. A large and diverse class of proteins that bind dsRNA do so by utilizing an approximately 70 amino acid motif referred to as the dsRNA-binding domain (dsRBD). We have determined a 1.9 A resolution crystal structure of the second dsRBD of Xenopus laevis RNA-binding protein A complexed with dsRNA. The structure shows that the protein spans 16 bp of dsRNA, interacting with two successive minor grooves and across the intervening major groove on one face of a primarily A-form RNA helix. The nature of these interactions explains dsRBD specificity for dsRNA (over ssRNA or dsDNA) and the apparent lack of sequence specificity. Interestingly, the dsRBD fold resembles a portion of the conserved core structure of a family of polynucleotidyl transferases that includes RuvC, MuA transposase, retroviral integrase and RNase H. Structural comparisons of the dsRBD-dsRNA complex and models proposed for polynucleotidyl transferase-nucleic acid complexes suggest that similarities in nucleic acid binding also exist between these families of proteins.

Journal ArticleDOI
TL;DR: The authors used policy capturing, a real-time method common in cognitive psychology, to capture the VC's "actual theories in use" versus their "espoused theories" and found that VCs are very consistent in their decision process.