Institution
University of Costa Rica
Education•San José, Costa Rica•
About: University of Costa Rica is a education organization based out in San José, Costa Rica. It is known for research contribution in the topics: Population & Venom. The organization has 9817 authors who have published 16781 publications receiving 238208 citations. The organization is also known as: UCR & Universidad de Costa Rica.
Topics: Population, Venom, Antivenom, Snake venom, Context (language use)
Papers published on a yearly basis
Papers
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TL;DR: This toxicovenomic study identified the 3FTx group of α-neurotoxins in the venom of N. melanoleuca as the relevant targets to be neutralized, which has implications for the improvement of current antivenoms and for the development of novel antivenom based on biotechnological approaches.
79 citations
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TL;DR: Identification of their membrane target(s), and a deeper understanding of the catalytic-dependent and -independent mechanisms that result in membrane destabilization, are two crucial, but still unclarified aspects of their myotoxic action.
Abstract: Phospholipases A2 (PLA2s) are abundant components in snake venoms, which play important toxic roles. This review focuses on group II PLA2s endowed with myotoxic effects, present in Viperidae venoms. These PLA2s are subdivided into catalytically-active (Asp49) PLA2s, and catalytically-inactive PLA2 homologues, the latter most frequently presenting the Lys49 substitution. Both protein subgroups induce skeletal muscle necrosis, although by different mechanisms. Current evidence indicates that phospholipid hydrolysis plays a central role in the necrotizing action of Asp49 myotoxins, whereas PLA2 homologues rely on the direct membrane-destabilizing actions of their cationic C-terminal region to achieve such effect, in the absence of catalysis. Both mechanisms converge in sarcolemmal permeabilization, triggering a series of intracellular events that lead to necrosis. Most viperid PLA2 myotoxins act only locally, but those forming heterodimeric complexes such as crotoxin spread to distant muscles and induce rhabdomyolysis. This divergence between local and systemic myotoxicity might be related to differences in binding specificity to cell targets. Nevertheless, the identity of molecular targets recognized by viperid PLA2 myotoxins remains elusive. Identification of their membrane target(s), and a deeper understanding of the catalytic-dependent and -independent mechanisms that result in membrane destabilization, are two crucial, but still unclarified aspects of their myotoxic action.
79 citations
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TL;DR: A myotoxic phospholipase A2 was isolated from the venom of the South American snake Bothrops jararacussu and the pathogenesis of myonecrosis induced by this toxin was studied in mice, demonstrating that this toxin affects muscle fibers by first disrupting the integrity of plasma membrane.
79 citations
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TL;DR: In this paper, the link between chirality in the fermion sector and (anti-)self-duality of the boson sector is reexamined in the light of Connes' noncommutative geometry approach to the Standard Model.
79 citations
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TL;DR: In this article, a multinivel approach was used to predict calificaciones finales en cursos de carrera, for una muestra estratificada, por areas academicas, of 848 estudiantes de la Universidad de Costa Rica.
Abstract: Se realizo un analisis multinivel para predecir calificaciones finales en cursos de carrera, para una muestra estratificada, por areas academicas, de 848 estudiantes de la Universidad de Costa Rica. Se utilizaron como variables independientes un conjunto de factores en dimensiones institucionales, sociodemograficas, psicosociales y pedagogicas. El mejor predictor fue el Promedio de Admision, medida que combina notas de secundaria y el puntaje en una prueba de habilidades de razonamiento. Tambien variables no cognitivas resultaron explicativas, siendo la mas importante el puntaje de una escala de inteligencia emocional. La metodologia empleada por el (la) docente mostro asimismo poder explicativo.
79 citations
Authors
Showing all 9922 results
Name | H-index | Papers | Citations |
---|---|---|---|
Alberto Ascherio | 136 | 462 | 69578 |
Gervasio Gomez | 133 | 1844 | 99695 |
Myron M. Levine | 123 | 789 | 60865 |
Hong-Cai Zhou | 114 | 489 | 66320 |
Edward O. Wilson | 101 | 406 | 89994 |
Mary Claire King | 100 | 336 | 47454 |
Olga Martín-Belloso | 86 | 384 | 23428 |
José María Gutiérrez | 84 | 607 | 26779 |
Cesare Montecucco | 84 | 382 | 27738 |
Rodolphe Clérac | 78 | 506 | 22604 |
Kim R. Dunbar | 74 | 470 | 20262 |
Paul J. Hanson | 70 | 251 | 19504 |
Hannia Campos | 69 | 210 | 15164 |
Jean-Pierre Gorvel | 67 | 231 | 15005 |
F. Albert Cotton | 66 | 1023 | 27647 |