University of Illinois at Urbana–Champaign

About: University of Illinois at Urbana–Champaign is a education organization based out in Urbana, Illinois, United States. It is known for research contribution in the topics: Population & Context (language use). The organization has 102114 authors who have published 225158 publications receiving 10116369 citations.

The RAST Server: Rapid Annotations using Subsystems Technology

Abstract: The number of prokaryotic genome sequences becoming available is growing steadily and is growing faster than our ability to accurately annotate them. We describe a fully automated service for annotating bacterial and archaeal genomes. The service identifies protein-encoding, rRNA and tRNA genes, assigns functions to the genes, predicts which subsystems are represented in the genome, uses this information to reconstruct the metabolic network and makes the output easily downloadable for the user. In addition, the annotated genome can be browsed in an environment that supports comparative analysis with the annotated genomes maintained in the SEED environment. The service normally makes the annotated genome available within 12–24 hours of submission, but ultimately the quality of such a service will be judged in terms of accuracy, consistency, and completeness of the produced annotations. We summarize our attempts to address these issues and discuss plans for incrementally enhancing the service. By providing accurate, rapid annotation freely to the community we have created an important community resource. The service has now been utilized by over 120 external users annotating over 350 distinct genomes.

The American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia. Report of the Multicenter Criteria Committee.

Abstract: To develop criteria for the classification of fibromyalgia, we studied 558 consecutive patients: 293 patients with fibromyalgia and 265 control patients. Interviews and examinations were performed by trained, blinded assessors. Control patients for the group with primary fibromyalgia were matched for age and sex, and limited to patients with disorders that could be confused with primary fibromyalgia. Control patients for the group with secondary-concomitant fibromyalgia were matched for age, sex, and concomitant rheumatic disorders. Widespread pain (axial plus upper and lower segment plus left- and right-sided pain) was found in 97.6% of all patients with fibromyalgia and in 69.1% of all control patients. The combination of widespread pain and mild or greater tenderness in greater than or equal to 11 of 18 tender point sites yielded a sensitivity of 88.4% and a specificity of 81.1%. Primary fibromyalgia patients and secondary-concomitant fibromyalgia patients did not differ statistically in any major study variable, and the criteria performed equally well in patients with and those without concomitant rheumatic conditions. The newly proposed criteria for the classification of fibromyalgia are 1) widespread pain in combination with 2) tenderness at 11 or more of the 18 specific tender point sites. No exclusions are made for the presence of concomitant radiographic or laboratory abnormalities. At the diagnostic or classification level, the distinction between primary fibromyalgia and secondary-concomitant fibromyalgia (as defined in the text) is abandoned.

Subjective Well-Being: Three Decades of Progress

Abstract: W. Wilson's (1967) review of the area of subjective well-being (SWB) advanced several conclusions regarding those who report high levels of "happiness". A number of his conclusions have been overturned: youth and modest aspirations no longer are seen as prerequisites of SWB. E. Diener's (1984) review placed greater emphasis on theories that stressed psychological factors. In the current article, the authors review current evidence for Wilson's conclusions and discuss modern theories of SWB that stress dispositional influences, adaptation, goals, and coping strategies. The next steps in the evolution of the field are to comprehend the interaction of psychological factors with life circumstances in producing SWB, to understand the causal pathways leading to happiness, understand the processes underlying adaptation to events, and develop theories that explain why certain variables differentially influence the different components of SWV (life satisfaction, pleasant affect, and unpleasant affect).

The capacity of wireless networks

Abstract: When n identical randomly located nodes, each capable of transmitting at W bits per second and using a fixed range, form a wireless network, the throughput /spl lambda/(n) obtainable by each node for a randomly chosen destination is /spl Theta/(W//spl radic/(nlogn)) bits per second under a noninterference protocol. If the nodes are optimally placed in a disk of unit area, traffic patterns are optimally assigned, and each transmission's range is optimally chosen, the bit-distance product that can be transported by the network per second is /spl Theta/(W/spl radic/An) bit-meters per second. Thus even under optimal circumstances, the throughput is only /spl Theta/(W//spl radic/n) bits per second for each node for a destination nonvanishingly far away. Similar results also hold under an alternate physical model where a required signal-to-interference ratio is specified for successful receptions. Fundamentally, it is the need for every node all over the domain to share whatever portion of the channel it is utilizing with nodes in its local neighborhood that is the reason for the constriction in capacity. Splitting the channel into several subchannels does not change any of the results. Some implications may be worth considering by designers. Since the throughput furnished to each user diminishes to zero as the number of users is increased, perhaps networks connecting smaller numbers of users, or featuring connections mostly with nearby neighbors, may be more likely to be find acceptance.