Showing papers by "University of Leeds published in 1993"

Wavelets and Operators

Abstract: Over the last two years, wavelet methods have shown themselves to be of considerable use to harmonic analysts and, in particular, advances have been made concerning their applications. The strength of wavelet methods lies in their ability to describe local phenomena more accurately than a traditional expansion in sines and cosines can. Thus, wavelets are ideal in many fields where an approach to transient behaviour is needed, for example, in considering acoustic or seismic signals, or in image processing. Yves Meyer stands the theory of wavelets firmly upon solid ground by basing his book on the fundamental work of Calderon, Zygmund and their collaborators. For anyone who would like an introduction to wavelets, this book will prove to be a necessary purchase.

Management, masculinity and manipulation: from paternalism to corporate strategy in financial services in britain*

Abstract: This article is concerned to demonstrate that paternalism and strategic management as forms, styles or ‘techniques’of managing people and organizations, are both constitutive of and embedded in what we term a ‘discourse of masculinism’. Within the context of the UK financial services industry, we examine how this discourse reflects and reproduces management practices, and reconstitutes individuals in accordance with masculinist priorities. This has the effect of privileging men vis-a-vis women, serves to rank some men above others, and maintains as dominant certain forms and practices of masculinity. We identify two of these as ‘paternalistic masculinity’and ‘competitive masculinity’respectively, regarding them as concrete manifestations of the interplay between historically shifting forms of management and masculinities in operation.

Selective serotonin reuptake inhibitors: meta-analysis of efficacy and acceptability.

Abstract: OBJECTIVE--To examine the evidence for using selective serotonin reuptake inhibitors instead of tricyclic antidepressants in the first line treatment of depression. DESIGN--Meta-analysis of 63 randomised controlled trials comparing the efficacy and acceptability of selective serotonin reuptake inhibitors with those of tricyclic and related antidepressants. MAIN OUTCOME MEASURES--Improvement in mean scores on Hamilton depression rating scale for 53 randomised controlled trials. Pooled drop out rates from the 58 trials which reported drop out by treatment group. RESULTS--Among the 20 studies reporting standard deviation for the Hamilton score no difference was found in efficacy between serotonin reuptake inhibitors and tricyclic and related antidepressants (standardised mean difference 0.004, 95% confidence interval -0.096 to 0.105). The difference remained insignificant when the remaining 33 studies that used the 17 item and 21 item Hamilton score were included by ascribing weighted standard deviations. The odds ratio for drop out rate in patients receiving serotonin reuptake inhibitors compared with those receiving tricyclic antidepressants was 0.95 (0.86 to 1.07). Similar proportions in both groups cited lack of efficacy as the reason for dropping out but slightly more patients in the tricyclic group cited side effects (18.8% v 15.4% in serotonin reuptake group). CONCLUSIONS--Routine use of selective serotonin reuptake inhibitors as the first line treatment of depressive illness may greatly increase cost with only questionable benefit.

Structure and sequence relationships in the lipocalins and related proteins.

Abstract: The lipocalins and fatty acid-binding proteins (FABPs) are two recently identified protein families that both function by binding small hydrophobic molecules. We have sought to clarify relationships within and between these two groups through an analysis of both structure and sequence. Within a similar overall folding pattern, we find large parts of the lipocalin and FABP structures to be quantitatively equivalent. The three largest structurally conserved regions within the lipocalin common core correspond to characteristic sequence motifs that we have used to determine the constitution of this family using an iterative sequence analysis procedure. This afforded a new interpretation of the family, which highlighted the difficulties of determining a comprehensive and coherent classification of the lipocalins. The first of the three conserved sequence motifs is also common to the FABPs and corresponds to a conserved structural element characteristic of both families. Similarities of structure and sequence within the two families suggests that they form part of a larger "structural superfamily"; we have christened this overall group the calycins to reflect the cup-shaped structure of its members.

Hydrolysis of human and pig brain natriuretic peptides, urodilatin, C-type natriuretic peptide and some C-receptor ligands by endopeptidase-24.11

Abstract: Endopeptidase-24.11 (E-24.11, EC 3.4.24.11) is widely believed to play a physiological role in metabolizing atrial natriuretic peptide (ANP). Since the discovery of ANP, new natriuretic peptides have been isolated and other peptides synthesized as receptor ligands. The hydrolysis in vitro of six related peptides by the endopeptidase has been studied, mainly by h.p.l.c. The initial attack on the 32-residue form of pig brain natriuretic peptide (pBNP-32) was shown to be at the Ser20-Leu21 bond, as had been previously shown for the 26-residue form. In contrast, human brain natriuretic peptide-32 (hBNP-32), which differs in ten residues from pBNP-32, was attacked first at the Met4-Val5 bond, releasing the N-terminal tetrapeptide, and only later at bonds within the ring: at Arg17-Ile18 and subsequently at four other sites. Urodilatin, which has a four-residue extension at the N-terminus compared with alpha-human atrial natriuretic peptide-28 (alpha-hANP), was degraded at about half the rate of the latter, though the C-terminal Phe-Arg-Tyr was released at the same rate. The 22-residue C-type natriuretic peptide was hydrolysed more rapidly than alpha-hANP, as were two C-receptor ligands (peptides with deletions within the ring): C-ANP4-23 (rANP4-23 des-Gln18,Ser19,Gly20,Leu21,Gly22) and SC 46542 (hANP5-28 des-Phe8,Gly9,Ala17,Gln18). Angiotensin-converting enzyme failed to hydrolyse pBNP-32, hBNP-32 or 125I-rat (r) ANP, even after prolonged incubation. Km and kcat values were determined for the hydrolysis of alpha-hANP, porcine BNP-26, porcine BNP-32 and 125I-rANP by E-24.11. Ki values were determined for six peptides, alpha-hANP, urodilatin, hBNP-32, C-type natriuretic peptide (CNP), SC 46542 and C-type natriuretic peptide (C-ANP4-23), in radiometric assays of E-24.11 with either [125I] insulin B chain or [125I] rANP as substrate. The Ki values (2.5-13 microM) for CNP were the lowest of any of the group, whereas those for hBNP-32 (151-172 microM) were the highest. The physiological significance of these results is discussed, especially in regard to the relative resistance of hBNP-32 to attack and the ability of the C-receptor ligands to compete with natriuretic peptides for hydrolysis by E-24.11.

Image pre-processing

Abstract: Pre-processing is a common name for operations with images at the lowest level of abstraction — both input and output are intensity images. These iconic images are of the same kind as the original data captured by the sensor, with an intensity image usually represented by a matrix of image function values (brightnesses). The aim of pre-processing is an improvement of the image data that suppresses unwilling distortions or enhances some image features important for further processing, although geometric transformations of images (e.g. rotation, scaling, translation) are classified among pre-processing methods here since similar techniques are used.

Late Eocene–Recent volcanism and faulting in the southern main Ethiopian rift

Abstract: Few constraints on the timing, amount and distribution of lithospheric extension associated with flood-basalt magmatism were available from the southern Main Ethiopian rift system, where the base of the Cenozoic volcanic succession is exposed by faulting. New structural observations, together with K–Ar and 40 Ar/ 39 Ar geochronology data from a transect of the Chamo basin–Amaro horst–Galana basin, show that basins are bounded by faults with steep dips at the surface, and the stratal dips of Eocene–Recent volcanic and sedimentary units are generally less than 20°. Little or no extension accompanied the extrusion of a 0.5 to 1 km thick sequence of transitional tholeiitic flood basalts between 45 and 35 Ma. Stratigraphical correlations with basins to the north and southwest suggest that felsic eruption(s) at c. 37 Ma blanketed much of the southern Ethiopian plateau region with a felsic tuff unit. A second, less widespread, episode of alkali basalt and trachyte volcanism occurred between 18 and 11 Ma, and Recent alkali basalt volcanism occurs within the Chamo basin. The attitude, distribution, and diversity of Neo–gene–Recent volcanic and sedimentary strata within the Chamo and Galana basins indicate that crustal extension, basin subsidence, and rift flank uplift began during or after the second flood-basalt phase. Based on cross-sectional reconstruction to the top of the Oligocene tuff, we estimate a minimum of 12 km crustal extension (β ≈ 1.12), and infer that maximum extension across the southern Ethiopian rift is less than 25 km. Extension is primarily accommodated by slip along the border faults bounding the asymmetric basins, with small amounts of extension occurring within the hanging walls. Crude estimates of original basalt layer thickness prior to erosion in the Amaro region suggest that roughly comparable volumes of basaltic material erupted during the two episodes of flood-basalt magmatism (45–35 Ma and 18–11 Ma). The small amounts of lithospheric extension and the large volumes of magma estimated in this study of the southern Main Ethiopian rift suggest a very hot plume and/or efficient thinning of the mantle lithosphere from below by mantle plume processes during the two discrete episodes of flood-basalt volcanism.

The interaction between normal faulting and drainage in active extensional basins, with examples from the western United States and central Greece

Abstract: Faulting exerts an important control upon drainage development in active extensional basins and thus helps determine the architecture of the sedimentary infill to a synrift basin. Examples of the interaction between faulting and drainage from the western United States and central Greece may be grouped into a relatively small number of classes based upon the structural position of a drainage catchment: footwall, hangingwall, fault offset and axial. Our examples illustrate the diversity of erosional effects that might arise because of variations in the spacing, orientation and segmentation of faults and their interactions. Where basement lithology is similar, footwall catchments are generally smaller, shorter and steeper than those of the hangingwall. Footwall-sourced alluvial fans and fan deltas are generally smaller in area than those sourced from similar lithologies in the hangingwall. Wide fault offsets often give rise to large drainage catchments in the footwall. The development of axial drainage depends upon the breaching of transverse bedrock ridges by headward stream erosion or by lake overflow. Once breaching has occurred the direction of axial streamflow is controlled by the potential developed between basins of contrasting widths. Fault migration and propagation leads to the uplift, erosion and resedimentation of the sedimentary infill to formerly active basins, leading to the cutting of footwall unconformities. The outward sediment flux from structurally controlled catchments is modulated in an important way by lithology and runoff. The greatest contrasts in basement lithology arise when fault migration and propagation have occurred, such that the sedimentary fill to previously active basins is uplifted, incised and eroded by the establishment of large new drainage systems in the footwalls of younger faults. Drainage patterns in areas.where faults interact can shed light on the relative timing of activity and therefore the occurrence of fault migration and propagation. Facies and palaeocurrent trends in ancient grabens may only be correctly interpreted when observations are made on a length scale of 10-20 km, comparable to that of the largest fault segments.

Issues In Corporate Accountability and Governance: An Editorial

Abstract: (1993). Issues In Corporate Accountability and Governance: An Editorial. Accounting and Business Research: Vol. 23, Corporate Governance Special Issue, pp. 291-303.

SPROUT: A program for structure generation

Abstract: SPROUT is a new computer program for constrained structure generation that is designed to generate molecules for a range of applications in molecular recognition. It uses artificial intelligence techniques to moderate the combinatorial explosion that is inherent in structure generation. The program is presented here for the design of enzyme inhibitors. Structure generation is divided into two phases: (i) primary structure generation to produce molecular graphs to fit the steric constraints; and (ii) secondary structure generation which is the process of introducing appropriate functionality to the graphs to produce molecules that satisfy the secondary constraints, e.g., electrostatics and hydrophobicity. Primary structure generation has been tested on two enzyme receptor sites; the p-amidino-phenyl-pyruvate binding site of trypsin and the acetyl pepstatin binding site of HIV-1 protease. The program successfully generates structures that resemble known substrates and, more importantly, the predictive power of the program has been demonstrated by its ability to suggest novel structures.

A conceptual model of solute acquisition by Alpine glacial meltwaters

Abstract: Solute acquisition by Alpine glacial meltwaters is the result of the coupling of different pairs of reactions, one of which usually involves dissolved gases. Hence, the availability of atmospheric gases to solution is an important control on the composition of glacial meltwaters. The chemical compositions of the two main components of the bulk meltwater, quick flow and delayed flow, are dominated by different geochemical processes. Delayed flow waters are solute-rich and exhibit high p(CO2) characteristics. The slow transit of these waters through a distributed drainage system and the predominance of relatively rapid reactions, such as sulphide oxidation and carbonate dissolution, in this environment maximize solute acquisition. Quick-flow waters are dilute, both because of their rapid transit through ice-walled conduits and open channels, and because the weathering reactions are fuelled by relatively slow gaseous diffusion of (CO2) into solution, despite solute acquisition being dominated by rapid surface exchange reactions. As a consequence, quick flow usually bears a low or open-system p(CO2) signature. Bulk meltwaters are more likely to exhibit low p(CO2) values when suspended-sediment concentrations are high, which promotes post-mixing reactions. This conceptual model suggests that the composition of both quick flow and delayed flow is likely to be temporally variable, since kinetic, rather than equilibrium, factors determine the composition.

Dietary fat and appetite control in obese subjects: weak effects on satiation and satiety.

Abstract: The present study assessed the capacity of both high fat and high carbohydrate (CHO) foods to lead to overconsumption in 12 obese women (mean BMI = 42 kg/m2). Subjects were provided with either a low (527 kcal) or high (985 kcal) energy meal at midday. Energy intake was then measured in a later ad libitum dinner meal in which subjects ate from a range of either high fat or high CHO foods. Energy intake following exposure to these meals was then assessed using food intake diary records which were kept for the rest of the day and for the following 24 h. The energy manipulations at lunch gave rise to different levels in the rated intensity of hunger. At the dinner meal subjects consumed an average of 937 kcal following the high energy lunch and 1026 kcal following the low energy lunch (an increase of 10%). However, average intake from the high CHO dinner meal was only 677 kcal compared to 1336 kcal from the high fat dinner meal (an increase of 97%). Consequently the most important variable influencing dinner meal size was not level of hunger but the nutrient content of the range of foods consumed. Analysis of dinner meal intake revealed a significant interaction between lunch meal size and dinner meal type. This means that when hunger level was high subjects over-ate on the high fat but not the high CHO foods. Average post-dinner intakes following the high fat and high CHO meals did not differ significantly.(ABSTRACT TRUNCATED AT 250 WORDS)

Influence of prior maze experience on behaviour and response to diazepam in the elevated plus-maze and light/dark tests of anxiety in mice

Abstract: A single prior undrugged exposure to the elevated plus-maze has been reported to reduce open arm activity on retest and to attenuate/abolish the anxiolytic response to benzodiazepines at retest intervals ranging from 48 h to 14 days. The present study was designed to examine the generality of these findings by comparing the effects of prior maze experience on baseline behaviour and response to diazepam in two murine models of anxiety. Parallel experiments were conducted in which DBA/2 mice were exposed/not exposed to the plus-maze, treated daily with saline or diazepam (2-4 mg/kg daily for 8 days) and then tested on either the elevated plus-maze or in the light/dark test of exploration. Results show that, in both tests, diazepam reduced behavioural indices of anxiety in maze-naive mice only. However, interpretation of this apparent loss of diazepam efficacy is at least partially confounded by the observation that maze experience per se altered baseline behaviour in both procedures, reducing open arm activity in the plus-maze and increasing light compartment activity in the light/dark test. The apparent elimination of an anxiolytic response to diazepam in two animal models of anxiety by prior plus-maze experience is discussed in relation to experience-related baseline shifts in behaviour.

Placental malaria. I. Pathological classification.

Abstract: Pregnant women are more likely to contract malaria than their non-pregnant counterparts. The aim of this study was to develop a simple classification system for the histopathological diagnosis of placental malaria infection applicable to placentas collected in field conditions. The placentas were classified into four groups depending on the presence and distribution of parasites and malaria pigment: active infection, active-chronic infection, past-chronic infection, not infected. The frequency of parasitized placentas (26.4%) was in keeping with the prevalence of placental parasitaemia documented in epidemiological studies. An additional 29.8% placentas showed pigment in fibrin only, indicating past-chronic infection. Chronic placental malaria infection was most common in primigravidae, possibly reflecting ineffective clearance of parasites from the placenta. Seasonal fluctuations between infection categories support progression of placental infection with delayed clearance of pigment from fibrin. The proposed classification system has allowed diagnosis of different categories of placental malaria infection by two independent observers. A standardized method of diagnosis may enhance understanding of placental pathology and reduced birth weight in malaria infection during pregnancy.

The hot compaction of high modulus melt-spun polyethylene fibres

Abstract: The production of solid section highly oriented polyethylene by compaction of melt-spun polyethylene fibres is described. Differential scanning calorimetry, X-ray diffraction and electron microscopy have been used to determine the structure of the compacted polymer. The essential feature of the process is shown to be selective surface melting of the fibres to form a polyethylene/polyethylene composite of very high integrity, yet maintaining a very high proportion of the strength and stiffness of the fibres.

Rapid detection of allele loss in colorectal tumours using microsatellites and fluorescent DNA technology.

Abstract: In order to investigate allele loss in colorectal tumours we have developed a rapid technique which overcomes most of the problems associated with radioactive Restriction Fragment Length Polymorphism (RFLP) analysis of allele loss. We utilise microsatellite length polymorphisms which are highly informative and are closely linked to loci of interest. Sequences containing microsatellites can be amplified from normal and tumour DNA pairs by a polymerase chain reaction (PCR) in which one of the primers is fluorescently labelled. This enables us to detect the products on polyacrylamide gels run on an automated DNA sequencer using dedicated software, by which results are automatically quantitated in terms of peak size, height, and area. Using this technique we have analysed 26 normal tissue: cancer pairs for allele loss at two loci linked to the adenomatous polyposis coli (APC) gene on chromosome 5q. Repeated assays yielded identical results for each pair. Allele loss was found in 10 out of 25 informative samples (40%).

Asymptotic decay of liquid structure: oscillatory liquid-vapour density profiles and the Fisher-Widom line

Abstract: Recent work has highlighted the existence of a unified theory for the asymptotic decay of the density profile ρ(r) of an inhomogeneous fluid and of the bulk radial distribution function g(r). For a given short-ranged interatomic potential ρ(r) decays into bulk in the same fashion as g(r), i.e. with the same exponential decay length (α0/-1) and, for sufficiently high bulk density (ρb) and/or temperature (T), oscillatory wavelength (2π/α1). The quantities α0 and α1 are determined by a linear stability analysis of the bulk fluid; they depend on only the bulk direct correlation function. In this paper we reintroduce the concept of the Fisher-Widom (FW) line. This line was originally introduced, in say the (ρb, T plane, as that which separates pure exponential from exponentially damped oscillatory decay of g(r). We explore the relevance of the FW line for the form of the density profile at a liquid-vapour interface. Using a weighted density approximation (WDA) density functional theory we locate the FW line fo...