Institution
University of Texas Southwestern Medical Center
Healthcare•Dallas, Texas, United States•
About: University of Texas Southwestern Medical Center is a healthcare organization based out in Dallas, Texas, United States. It is known for research contribution in the topics: Population & Cancer. The organization has 39107 authors who have published 75242 publications receiving 4497256 citations. The organization is also known as: UT Southwestern & UT Southwestern Medical School.
Topics: Population, Cancer, Medicine, Gene, Receptor
Papers published on a yearly basis
Papers
More filters
600 citations
TL;DR: A role for Reelin is revealed in controlling synaptic plasticity in the adult brain and the impairment of apoE receptor-dependent neuromodulation may contribute to cognitive impairment and synaptic loss in Alzheimer disease.
599 citations
TL;DR: Transcription profiling of yaa-bearing B cells revealed the overexpression of a cluster of X-linked genes that included Tlr7, and FISH analysis demonstrated the translocation of this segment onto the yaa chromosome, suggesting that Sles1 modulates the activation of adaptive immunity in response to innate immune signaling.
Abstract: The y-linked autoimmune accelerating (yaa) locus is a potent autoimmune disease allele. Transcription profiling of yaa-bearing B cells revealed the overexpression of a cluster of X-linked genes that included Tlr7. FISH analysis demonstrated the translocation of this segment onto the yaa chromosome. The resulting overexpression of Tlr7 increased in vitro responses to Toll-like receptor (TLR) 7 signaling in all yaa-bearing males. B6.yaa mice are not overtly autoimmune, but the addition of Sle1, which contains the autoimmune-predisposing Slam/Cd2 haplotype, causes the development of fatal lupus with numerous immunological aberrations. B6.Sle1yaa CD4 T cells develop the molecular signature for TFH cells and also show expression changes in numerous cytokines and chemokines. Disease development and all component autoimmune phenotypes were inhibited by Sles1, a potent suppressor locus. Sles1 had no effect on yaa-enhanced TLR7 signaling in vitro, and these data place Sles1 downstream from the lesion in innate immune responses mediated by TLR7, suggesting that Sles1 modulates the activation of adaptive immunity in response to innate immune signaling.
598 citations
TL;DR: Data supporting the role of gelsolin in cytoskeletal remodeling and phosphoinositide signaling is summarized and the structural basis for the Ca and PIP2 regulation of severing and capping by gelsolini is discussed.
598 citations
TL;DR: NMIBC is a heterogeneous disease with varying therapies, follow-up strategies, and oncologic outcomes for an individual patient, and multiplicity, tumour size, and prior recurrence rate are the most important variables for recurrence.
598 citations
Authors
Showing all 39410 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Eugene Braunwald | 230 | 1711 | 264576 |
| Joseph L. Goldstein | 207 | 556 | 149527 |
| Eric N. Olson | 206 | 814 | 144586 |
| Craig B. Thompson | 195 | 557 | 173172 |
| Thomas C. Südhof | 191 | 653 | 118007 |
| Scott M. Grundy | 187 | 841 | 231821 |
| Michael S. Brown | 185 | 422 | 123723 |
| Eric Boerwinkle | 183 | 1321 | 170971 |
| Jiaguo Yu | 178 | 730 | 113300 |
| John J.V. McMurray | 178 | 1389 | 184502 |
| Eric J. Nestler | 178 | 748 | 116947 |
| John D. Minna | 169 | 951 | 106363 |
| Yuh Nung Jan | 162 | 460 | 74818 |
| Andrew P. McMahon | 162 | 415 | 90650 |
| Elliott M. Antman | 161 | 716 | 179462 |