Institution
University of Texas Southwestern Medical Center
Healthcare•Dallas, Texas, United States•
About: University of Texas Southwestern Medical Center is a healthcare organization based out in Dallas, Texas, United States. It is known for research contribution in the topics: Population & Cancer. The organization has 39107 authors who have published 75242 publications receiving 4497256 citations. The organization is also known as: UT Southwestern & UT Southwestern Medical School.
Topics: Population, Cancer, Medicine, Gene, Receptor
Papers published on a yearly basis
Papers
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TL;DR: It is shown that molecular recapitulations of three prototypical adaptations associated with the unsusceptible phenotype are each sufficient to promote resistant behavior and validate a multidisciplinary approach to examine the neurobiological mechanisms of variations in stress resistance.
1,863 citations
TL;DR: It is proposed that the NAc and VTA contribute importantly to the pathophysiology and symptomatology of depression and may even be involved in its etiology.
1,859 citations
TL;DR: It is found that TRAF6, a RING domain protein, functions together with Ubc13/Uev1A to catalyze the synthesis of unique polyubiquitin chains linked through lysine-63 (K63) of ubiquitin.
1,853 citations
TL;DR: Cl cloning and characterization of two ERK1-related kinases, ERK2 and ERK3, are described and evidence suggesting that there are additional ERK family members is provided, which may serve as intermediates that depend on tyrosine phosphorylation to activate serine/threonineosphorylation cascades.
1,853 citations
TL;DR: A conceptual framework to understand how and why metabolic reprogramming occurs in tumor cells, and the mechanisms linking altered metabolism to tumorigenesis and metastasis will progressively support the development of new strategies to treat human cancer.
Abstract: Tumors reprogram pathways of nutrient acquisition and metabolism to meet the bioenergetic, biosynthetic, and redox demands of malignant cells. These reprogrammed activities are now recognized as hallmarks of cancer, and recent work has uncovered remarkable flexibility in the specific pathways activated by tumor cells to support these key functions. In this perspective, we provide a conceptual framework to understand how and why metabolic reprogramming occurs in tumor cells, and the mechanisms linking altered metabolism to tumorigenesis and metastasis. Understanding these concepts will progressively support the development of new strategies to treat human cancer.
1,850 citations
Authors
Showing all 39410 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Eugene Braunwald | 230 | 1711 | 264576 |
| Joseph L. Goldstein | 207 | 556 | 149527 |
| Eric N. Olson | 206 | 814 | 144586 |
| Craig B. Thompson | 195 | 557 | 173172 |
| Thomas C. Südhof | 191 | 653 | 118007 |
| Scott M. Grundy | 187 | 841 | 231821 |
| Michael S. Brown | 185 | 422 | 123723 |
| Eric Boerwinkle | 183 | 1321 | 170971 |
| Jiaguo Yu | 178 | 730 | 113300 |
| John J.V. McMurray | 178 | 1389 | 184502 |
| Eric J. Nestler | 178 | 748 | 116947 |
| John D. Minna | 169 | 951 | 106363 |
| Yuh Nung Jan | 162 | 460 | 74818 |
| Andrew P. McMahon | 162 | 415 | 90650 |
| Elliott M. Antman | 161 | 716 | 179462 |