Current state and challenges in developing oral vaccines.
TLDR
The rationale for oral vaccines is addressed, including key biological and physicochemical considerations for next-generation oral vaccine design.About:
This article is published in Advanced Drug Delivery Reviews.The article was published on 2017-05-15 and is currently open access. It has received 227 citations till now. The article focuses on the topics: Tolerance induction.read more
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Encapsulation, protection, and delivery of bioactive proteins and peptides using nanoparticle and microparticle systems: A review.
TL;DR: A critical assessment of the characteristics of colloidal particles that impact the effectiveness of protein delivery systems, such as particle composition, size, permeability, interfacial properties, and stability are provided.
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Biomimetic Micromotor Enables Active Delivery of Antigens for Oral Vaccination.
Xiaoli Wei,Mara Beltrán-Gastélum,Emil Karshalev,Berta Esteban-Fernández de Ávila,Jiarong Zhou,Danni Ran,Pavimol Angsantikul,Ronnie H. Fang,Joseph Wang,Liangfang Zhang +9 more
TL;DR: A biomimetic self-propelling micromotor formulation is developed for use as an oral antivirulence vaccine, and it is confirmed that the propulsion greatly improves retention and uptake of the antigenic material in the small intestine in vivo.
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Enabling Technologies for Personalized and Precision Medicine
Dean Ho,Stephen R. Quake,Edward R.B. McCabe,Wee Joo Chng,Wee Joo Chng,Edward Kai-Hua Chow,Xianting Ding,Bruce D. Gelb,Geoffrey S. Ginsburg,Jason Hassenstab,Chih-Ming Ho,William C. Mobley,Garry P. Nolan,Steven T. Rosen,Patrick Tan,Yun Yen,Ali Zarrinpar +16 more
TL;DR: This work highlights key breakthroughs in the development of enabling technologies that further the goal of personalized and precision medicine, and remaining challenges that, when addressed, may forge unprecedented capabilities in realizing truly individualized patient care.
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Materials for Immunotherapy
C. Wyatt Shields,C. Wyatt Shields,Lily Li-Wen Wang,Lily Li-Wen Wang,Lily Li-Wen Wang,Michael A. Evans,Michael A. Evans,Samir Mitragotri,Samir Mitragotri +8 more
TL;DR: An overview of the materials used to enable or improve the success of immunotherapies in preclinical studies is presented, from immunosuppressive to proinflammatory strategies, with particular emphasis on technologies poised for clinical translation.
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Designing the new generation of intelligent biocompatible carriers for protein and peptide delivery.
TL;DR: Recent advances in formulation and drug delivery technologies to enhance bioavailability are discussed, including the co-administration of compounds to alter conditions in the GI tract, the modification of the macromolecule physicochemical properties, and the use of improved targeted and controlled release carriers.
References
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PLGA-based nanoparticles: An overview of biomedical applications
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TL;DR: This review presents why PLGA has been chosen to design nanoparticles as drug delivery systems in various biomedical applications such as vaccination, cancer, inflammation and other diseases.
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World health statistics.
TL;DR: It is a cause of rejoicing to be able to speak here today of World Health Statistics, not as one of the many desiderata still needed as a basis for a vigorous and wholesome international life, but as an accomplished fact.
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Liposome: classification, preparation, and applications
Abolfazl Akbarzadeh,Rogaie Rezaei-Sadabady,Rogaie Rezaei-Sadabady,Soodabeh Davaran,Sang Woo Joo,Nosratollah Zarghami,Younes Hanifehpour,Mohammad Samiei,Mohammad Kouhi,Kazem Nejati-Koshki +9 more
TL;DR: This paper summarizes exclusively scalable techniques and focuses on strengths and limitations in respect to industrial applicability and regulatory requirements concerning liposomal drug formulations based on FDA and EMEA documents.