J
Joseph B. Muhlestein
Researcher at Intermountain Medical Center
Publications - 340
Citations - 18961
Joseph B. Muhlestein is an academic researcher from Intermountain Medical Center. The author has contributed to research in topics: Coronary artery disease & Myocardial infarction. The author has an hindex of 66, co-authored 311 publications receiving 17498 citations. Previous affiliations of Joseph B. Muhlestein include University of Wisconsin-Madison & Primary Children's Hospital.
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Journal ArticleDOI
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease
Heribert Schunkert,Inke R. König,Sekar Kathiresan,Muredach P. Reilly,Themistocles L. Assimes,Hilma Holm,Michael Preuss,Alexandre F.R. Stewart,Maja Barbalić,Christian Gieger,Devin Absher,Zouhair Aherrahrou,Hooman Allayee,David Altshuler,Sonia S. Anand,Karl Andersen,Jeffrey L. Anderson,Diego Ardissino,Stephen G. Ball,Anthony J. Balmforth,Timothy A. Barnes,Diane M. Becker,Lewis C. Becker,Klaus Berger,Joshua C. Bis,S. Matthijs Boekholdt,Eric Boerwinkle,Peter S. Braund,Morris J. Brown,Mary Susan Burnett,Ian Buysschaert,John F. Carlquist,Li Chen,Sven Cichon,Veryan Codd,Robert W. Davies,George Dedoussis,Abbas Dehghan,Serkalem Demissie,Joseph M. Devaney,Patrick Diemert,Ron Do,Angela Doering,Sandra Eifert,Nour Eddine El Mokhtari,Stephen G. Ellis,Roberto Elosua,James C. Engert,Stephen E. Epstein,Ulf de Faire,Marcus Fischer,Aaron R. Folsom,Jennifer Freyer,Bruna Gigante,Domenico Girelli,Solveig Gretarsdottir,Vilmundur Gudnason,Jeffrey R. Gulcher,Eran Halperin,Naomi Hammond,Stanley L. Hazen,Albert Hofman,Benjamin D. Horne,Thomas Illig,Carlos Iribarren,Gregory T. Jones,J. Wouter Jukema,Michael A. Kaiser,Lee M. Kaplan,John J.P. Kastelein,Kay-Tee Khaw,Joshua W. Knowles,G. Kolovou,Augustine Kong,Reijo Laaksonen,Diether Lambrechts,Karin Leander,Guillaume Lettre,Mingyao Li,Wolfgang Lieb,Christina Loley,Andrew J. Lotery,Pier Mannuccio Mannucci,Seraya Maouche,Nicola Martinelli,Pascal P. McKeown,Christa Meisinger,Thomas Meitinger,Olle Melander,Pier Angelica Merlini,Vincent Mooser,Thomas M. Morgan,Thomas W. Mühleisen,Joseph B. Muhlestein,Thomas Münzel,Kiran Musunuru,Janja Nahrstaedt,Christopher P. Nelson,Markus M. Nöthen,Oliviero Olivieri,Riyaz S. Patel,Christopher Patterson,Annette Peters,Flora Peyvandi,Liming Qu,Arshed A. Quyyumi,Daniel J. Rader,Loukianos S. Rallidis,Catherine M. Rice,Frits R. Rosendaal,Diana Rubin,Veikko Salomaa,M. Lourdes Sampietro,M. S. Sandhu,Eric E. Schadt,Arne Scḧsignfer,Arne Schillert,Stefan Schreiber,Jürgen Schrezenmeir,Stephen M. Schwartz,David S. Siscovick,Mohan U. Sivananthan,Suthesh Sivapalaratnam,Albert V. Smith,Tamara B. Smith,Jaapjan D. Snoep,Nicole Soranzo,John A. Spertus,Klaus Stark,Kathy Stirrups,Monika Stoll,W.H. Wilson Tang,Stephanie Tennstedt,Gudmundur Thorgeirsson,Gudmar Thorleifsson,Maciej Tomaszewski,André G. Uitterlinden,Andre M. van Rij,Benjamin F. Voight,Nicholas J. Wareham,George A. Wells,H.-Erich Wichmann,Philipp S. Wild,Christina Willenborg,Jaqueline C M Witteman,Benjamin J. Wright,Shu Ye,Tanja Zeller,Andreas Ziegler,François Cambien,Alison H. Goodall,L. Adrienne Cupples,Thomas Quertermous,Winfried Mäsignrz,Christian Hengstenberg,Stefan Blankenberg,Willem H. Ouwehand,Alistair S. Hall,Panos Deloukas,John R. Thompson,Kari Stefansson,Robert Roberts,Unnur Thorsteinsdottir,Christopher J. O'Donnell,Ruth McPherson,Jeanette Erdmann,Nilesh J. Samani +166 more
TL;DR: This paper performed a meta-analysis of 14 genome-wide association studies of coronary artery disease (CAD) comprising 22,233 individuals with CAD (cases) and 64,762 controls of European descent followed by genotyping of top association signals in 56,682 additional individuals.
Journal ArticleDOI
Which White Blood Cell Subtypes Predict Increased Cardiovascular Risk
Benjamin D. Horne,Jeffrey L. Anderson,Jeffrey L. Anderson,Jerry M. John,Jerry M. John,Aaron N. Weaver,Aaron N. Weaver,Tami L Bair,Kurt R. Jensen,Dale G. Renlund,Dale G. Renlund,Joseph B. Muhlestein,Joseph B. Muhlestein +12 more
TL;DR: Total WBC count is confirmed to be an independent predictor of death/MI in patients with or at high risk for CAD, but greater predictive ability is provided by high N (Q4 >6.6 x 10(3)/microl) or low L counts.
Journal ArticleDOI
Randomized Trial of Genotype-Guided Versus Standard Warfarin Dosing in Patients Initiating Oral Anticoagulation
Jeffrey L. Anderson,Benjamin D. Horne,Scott M. Stevens,Amanda Grove,Stephanie Barton,Zachery P. Nicholas,Samera F.S. Kahn,Heidi T. May,Samuelson K,Joseph B. Muhlestein,John F. Carlquist +10 more
TL;DR: An algorithm guided by pharmacogenetic and clinical factors improved the accuracy and efficiency of warfarin dose initiation and showed promise for wild-type and multiple variant genotypes.
Journal ArticleDOI
Relation of Vitamin D Deficiency to Cardiovascular Risk Factors, Disease Status, and Incident Events in a General Healthcare Population
Jeffrey L. Anderson,Jeffrey L. Anderson,Heidi T May,Benjamin D. Horne,Benjamin D. Horne,Tami L Bair,Nathaniel L. Hall,Nathaniel L. Hall,John F. Carlquist,John F. Carlquist,Donald L. Lappé,Joseph B. Muhlestein,Joseph B. Muhlestein +12 more
TL;DR: A high prevalence of vitamin D deficiency in the general healthcare population and an association between vitamin D levels and prevalent and incident CV risk factors and outcomes are confirmed, lending strong support to the hypothesis that vitamin D might play a primary role in CV risk Factors and disease.
Journal ArticleDOI
Ischemic Heart Disease Events Triggered by Short-Term Exposure to Fine Particulate Air Pollution
C. Arden Pope,Joseph B. Muhlestein,Heidi T May,Dale G. Renlund,Jeffrey L. Anderson,Benjamin D. Horne +5 more
TL;DR: Short-term particulate exposures contributed to acute ischemic coronary events, especially among patients with underlying coronary artery disease, and individuals with stable presentation and those with angiographically demonstrated clean coronaries are not as susceptible to short- term particulate exposure.