Journal ArticleDOI
Impact of high-fat diet on the intestinal microbiota and small intestinal physiology before and after the onset of obesity
TLDR
Prebiotics, probiotics, polyphenols, peroxisome proliferator-activated receptor-γ agonists and exercise have been shown to reverse HFD-induced intestinal phenotype and to attenuate the severity of obesity and its associated metabolic complications.About:
This article is published in Biochimie.The article was published on 2017-10-01. It has received 185 citations till now. The article focuses on the topics: Proinflammatory cytokine & Small intestine.read more
Citations
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Journal ArticleDOI
Mucus barrier, mucins and gut microbiota: the expected slimy partners?
Paola Paone,Patrice D. Cani +1 more
TL;DR: Different aspects of the mucus layer are debated by focusing on its chemical composition, regulation of synthesis and degradation by the microbiota as well as some characteristics of the slime layer in both physiological and pathological situations.
Journal ArticleDOI
The Role of Gut Microbiota in Intestinal Inflammation with Respect to Diet and Extrinsic Stressors.
TL;DR: The roles of the gut microbiota in intestinal inflammation in relation to diet and other extrinsic stressors are discussed.
Journal ArticleDOI
Gut microbes from the phylogenetically diverse genus Eubacterium and their various contributions to gut health
TL;DR: This review provides an overview of Eubacterium species from a phylogenetic perspective, describes how they alter with diet and age and summarizes its association with the human gut and various health conditions.
Journal ArticleDOI
Nutritional Components in Western Diet Versus Mediterranean Diet at the Gut Microbiota-Immune System Interplay. Implications for Health and Disease.
Cielo García-Montero,Oscar Fraile-Martínez,Ana M Gómez-Lahoz,Leonel Pekarek,Alejandro J. Castellanos,Fernando Noguerales-Fraguas,Santiago Coca,Santiago Coca,Luis G. Guijarro,Natalio García-Honduvilla,Natalio García-Honduvilla,Ángel Asúnsolo,Ángel Asúnsolo,Lara Sanchez-Trujillo,Lara Sanchez-Trujillo,Guillermo Lahera,Guillermo Lahera,Julia Buján,Julia Buján,Jorge Monserrat,Jorge Monserrat,Melchor Alvarez-Mon,Miguel Angel Alvarez-Mon,Miguel A Ortega +23 more
TL;DR: In this article, the regulatory role of nutritional components of WD and MD in the gut microbiota and immune system interplay, in order to understand, and create awareness of, the influence of diet over both key components.
Journal ArticleDOI
Increased jejunal permeability in human obesity is revealed by a lipid challenge and is linked to inflammation and type 2 diabetes.
Laurent Genser,Doriane Aguanno,Hédi Soula,Liping Dong,Laurence Trystram,Karen E. Assmann,Joe-Elie Salem,Jean-Christophe Vaillant,Jean-Michel Oppert,Fabienne Laugerette,Marie-Caroline Michalski,Philippe Wind,Monique Rousset,Edith Brot-Laroche,Armelle Leturque,Karine Clément,Sophie Thenet,Christine Poitou +17 more
TL;DR: Inter intestinal barrier defects are present in human severe obesity and exacerbated by a lipid challenge, which paves the way to the development of novel therapeutic approaches to modulate intestinal barrier function or personalize nutrition therapy to decrease lipid‐induced jejunal leakage in metabolic diseases.
References
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Journal ArticleDOI
An obesity-associated gut microbiome with increased capacity for energy harvest
Peter J. Turnbaugh,Ruth E. Ley,Michael A. Mahowald,Vincent Magrini,Elaine R. Mardis,Jeffrey I. Gordon +5 more
TL;DR: It is demonstrated through metagenomic and biochemical analyses that changes in the relative abundance of the Bacteroidetes and Firmicutes affect the metabolic potential of the mouse gut microbiota and indicates that the obese microbiome has an increased capacity to harvest energy from the diet.
Journal ArticleDOI
Microbial ecology: Human gut microbes associated with obesity
TL;DR: It is shown that the relative proportion of Bacteroidetes is decreased in obese people by comparison with lean people, and that this proportion increases with weight loss on two types of low-calorie diet.
Journal ArticleDOI
Inflammation and metabolic disorders
TL;DR: Dysfunction of the immune response and metabolic regulation interface can be viewed as a central homeostatic mechanism, dysfunction of which can lead to a cluster of chronic metabolic disorders, particularly obesity, type 2 diabetes and cardiovascular disease.
Journal ArticleDOI
Enterotypes of the human gut microbiome
Manimozhiyan Arumugam,Jeroen Raes,Eric Pelletier,Denis Le Paslier,Takuji Yamada,Daniel R. Mende,Gabriel Fernandes,Julien Tap,Thomas Brüls,Jean-Michel Batto,Marcelo Bertalan,Natalia Borruel,Francesc Casellas,Leyden Fernández,Laurent Gautier,Torben Hansen,Masahira Hattori,Tetsuya Hayashi,Michiel Kleerebezem,Ken Kurokawa,Marion Leclerc,Florence Levenez,Chaysavanh Manichanh,H. Bjørn Nielsen,Trine Nielsen,Nicolas Pons,Julie Poulain,Junjie Qin,Thomas Sicheritz-Pontén,Sebastian Tims,David Torrents,Edgardo Ugarte,Erwin G. Zoetendal,Jun Wang,Francisco Guarner,Oluf Pedersen,Willem M. de Vos,Søren Brunak,Joël Doré,Jean Weissenbach,S. Dusko Ehrlich,Peer Bork +41 more
TL;DR: Three robust clusters (referred to as enterotypes hereafter) are identified that are not nation or continent specific and confirmed in two published, larger cohorts, indicating that intestinal microbiota variation is generally stratified, not continuous.
Journal ArticleDOI
Obesity alters gut microbial ecology
Ruth E. Ley,Fredrik Bäckhed,Peter J. Turnbaugh,Catherine A. Lozupone,Robin D. Knight,Jeffrey I. Gordon +5 more
TL;DR: Analysis of the microbiota of genetically obese ob/ob mice, lean ob/+ and wild-type siblings, and their ob/+ mothers, all fed the same polysaccharide-rich diet, indicates that obesity affects the diversity of the gut microbiota and suggests that intentional manipulation of community structure may be useful for regulating energy balance in obese individuals.
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