Showing papers in "Journal of Fluorine Chemistry in 2010"

TL;DR: The top 10 fluorine containing pharmaceuticals (by US Sales in 2008) are highlighted in this article, where the structures and modes of action of these important drugs compounds are reviewed and representative synthetic routes are highlighted.

TL;DR: In this article, the synthesis of α-fluorinated ethers, thioethers, amines, and phosphines is reviewed and an updated overview of the synthesis process is given.

TL;DR: In this article, the reaction of hypervalent iodine trifluoromethylating reagents with a variety of arenes and N-heteroarenes gives access to the corresponding triffluoromethsylated compounds.

TL;DR: In this article, trifluoromethylation of aromatic and hetero-aromatic compounds by CF3I in the presence of Fe(II) compound, H2O2 and dimethylsulfoxide was investigated.

TL;DR: In this article, a review article provides a critical overview of several different synthetic approaches developed for asymmetric preparation of fluorine-containing amines, amino alcohols, α- and β-amino acids.

TL;DR: In this paper, a facile and efficient synthesis of polyhydroquinoline derivatives was reported via four-component condensation reaction of aldehydes, dimedone, active methylene compounds, and ammonium acetate in the presence of Hf(NPf 2 ) 4 in C 10 F 18 at 60

TL;DR: In this paper, new synthetic routes to (NHC)copper-trifluoroacetate and -chlorodifluoracetate complexes were developed (n-heterocyclic carbenes) so baseline reactivity patterns could be established for the decarboxylative trifluorsomethylation of organic halides.

TL;DR: In this article, the authors investigated the feasibility of using synthetic siderite for F− removal from aqueous solution and found that F− adsorption was spontaneous and exothermic in nature.

TL;DR: In this paper, a simple generation, in situ, of silver and n-tetrabutylammonium trifluoromethoxides which were able to react with electrophilic substrates was described.

TL;DR: In this article, the effect of various parameters like complexation and precipitation time, lanthanum loading and ammonia strength on fluoride removal have been studied and it is observed that the parameters for the synthesis of LCB have significant influence on development of the LCB and in turn on the fluoride removal capacity.

TL;DR: In this paper, trifluoroacetaldehyde was used as a starting compound for the synthesis of chiral α-substituted Trifluoromethyl tert-butyl sulfinimine derivatives.

TL;DR: A simple, inexpensive, environmentally friendly and efficient route for the synthesis of benzimidazole and formamidine derivatives by the reaction of O-phenylenediamines or amines with orthoesters using hexafluoroisopropanol as a solvent/catalyst is described in this paper.

TL;DR: In this paper, a solution polymerization of 2-(perfluoro-(1,1-bis-isopropyl)-2-propenyl)oxyethyl methacrylate (POMA) with butyl acrylate, MA, and methacrylic acid (MAA) initiated by AIBN in the co-solvents of ethyl acetate, butyl alcohol and toluene was successfully prepared.

TL;DR: Fluoroacrylate copolymer mini-mulsion was prepared by mini-emulsion polymerization under microwave irradiation as mentioned in this paper, and the morphology, size and size distribution of the latex particles as well as changes in the size during polymerization were characterized by TEM and photon correlation spectroscopy (PCS).

TL;DR: In this paper, two methods of nucleophilic fluorination to prepare α-fluoroacetophenones from α-bromoacetophenone by using KF with PEG-400 or TBAF with ZnF2 are described.

TL;DR: In this paper, the structure of 2,4-dinitrotrifluoromethylbenzene has been elucidated and the reactions of both copper species with 2.4-Dinitrochlorobenzene, 4-iodonitrobenzenesene and 4-nitrogen iodide have been studied.

TL;DR: In this article, a comprehensive spectroscopic characterization of all known crystalline AlF3 phases (α-, β-, η-, κ-, θ-AlF3) is presented for the first time.

TL;DR: In this article, the authors demonstrate that the racemic form of isopropyl 3,3,3-trifluoro-2-hydroxypropanoate (1) sublimed faster regardless of the starting enantiomeric composition.

TL;DR: In this article, N-phenyl-3, 3,3,3-trifluorolactic acid amides were used as a substrate for the study of SDE via sublimation.

TL;DR: In this article, the single crystal structures of five co-crystals formed by the reaction of different iodide and bromide salts with di- and triiodoperfluorobenzenes (I-ArF) are reported.

TL;DR: A mass-spectrometric determination of the sublimation pressure diagram of α -trifluoromethyl)-lactic acid as a function of its enantiomeric composition at 293 K was performed in this paper.

TL;DR: In this paper, an H/F σ-bond metathesis exchange of both vinylic C-F bonds of perfluorocyclobutene was studied.

TL;DR: In this article, 2,3,4,5,6-Pentafluorobiphenyl (PFBi) was modified by the nucleophilic substitution of one fluorine using a series of O-, S- and N-nucleophiles, viz.

TL;DR: In this article, a boron hydroxide derivative reacts with fluoride anions under acidic conditions to afford the corresponding fluoride derivative 4-fluoro-4-phenyl-1,3,5,7,8-pentamethyl-3a,4a-diaza,4-bora-s-indacene (4).

TL;DR: Several new synthesis methods of fluorinated carbon nanofibres, such as controlled fluorination using fluorinating agent (TbF4 or XeF 2), or assisted fluorination under UV and gamma irradiation, are reviewed and compared with the direct fluorine gas.

TL;DR: An historical overview of some of the author's contributions to the organometallic chemistry of fluorinated organic ligands is presented in this article, along with an overview of their work in the literature.

TL;DR: In this article, a detailed reaction mechanism was developed and used to model experimental data on the pyrolysis of CHF 3 and the non-oxidative gas-phase reaction with CH 4 in an alumina tube reactor at temperatures between 873 and 1173 K and at atmospheric pressure.

TL;DR: An optimized procedure for the multigram synthesis of 3-(trifluoromethyl)bicyclo[1.1]pent-1-ylglycine (CF 3 -Bpg) has been developed in this paper.

TL;DR: In this paper, the authors showed that α-trifluoromethyl lactic acid amide derivatives have substantial magnitude of the self-disproportionation of enantiomers (SDE) via sublimation.

TL;DR: In this paper, the self-disproportionation of enantiomers of heterocycles having a tertiary trifluoromethyl alcohol center on an achiral silica-gel stationary phase is discussed.