Showing papers in "Phytomedicine in 2017"

TL;DR: Over 1000 research articles published on neem has uncovered over 300 structurally diverse constituents, one third of which are limonoids including nimbolide, azadarachtin, and gedunin, which manifest their effects by modulating multiple cell signaling pathways.

TL;DR: The results suggested that, compared to the normal rats, the structure of gut microbiota was significantly changed in diabetic rats, and oral administration with TSPK and PSPK could prevent T2D by its regulation role on the gut microbiota.

TL;DR: The reviewed studies presented evidence that green tea influences psychopathological symptoms and brain function and beneficial green tea effects on cognition are observed under the combined influence of both caffeine and l-theanine, whereas separate administration of either substance was found to have a lesser impact.

TL;DR: It is hypothesized that natural products from plants may also protect from radiation damage caused as adverse side effects of cancer radiotherapy, and some secondary metabolites from plants reveal radioprotective features against cellular damage caused by irradiation.

TL;DR: Several promising results on the potentiation effects of antifungals' and antibacterials' activities by low MW natural products mainly on polyphenols and terpenes were reported in the literature and, in spite of that most works included only in vitro assays, this knowledge opens a wide range of possibilities for the combination antimicrobial therapy.

TL;DR: A comprehensive and critical review of known pharmacological and biological effects of butein, an important chalcone polyphenol first isolated from Rhus verniciflua Stokes, implicated in the prevention and treatment of various chronic disease conditions.

TL;DR: It is demonstrated that icariin has neuroprotective effect on dopaminergic neurons in PD mice model and the potential mechanisms might be related to PI3K/Akt and MEK/ERK pathways.

TL;DR: The beneficial role of PZA is demonstrated in renal fibrosis and podocyte injury and it is highlighted that PZA inhibits RAS and further suppresses TGF-β/Smad pathway through inhibiting Smad2/3 phosphorylation via blocking Smad-TGFβRI protein interaction.

TL;DR: Further preclinical studies are required to confirm the pharmacological properties of α-asarone against depression, anxiety, Parkinson's disease, psychosis, drug dependence, pain, inflammation, cholestasis and thrombosis.

TL;DR: Local population has a rich indigenous knowledge, but is always stays not adequately documented, and some listed species are suffering from surexploitation which can subjects to the disappearance of the most vulnerable species.

TL;DR: The synergistic interaction of ferulic acid and metformin is due their action on parallel pathways which are involved in glucose uptake, and it is possible to reduce the dose of met formin (by combining with ferulic Acid) required to achieve normoglycemia.

TL;DR: Harmine might be a potent inducer of apoptosis and autophagy, which offered evidences to therapy of harmine in gastric carcinoma in the folk medicine.

TL;DR: Successful treatment of all 18 ACT-resistant severe malaria cases suggests that DLA should be rapidly incorporated into the antimalarial regimen for Africa and possibly wherever else ACT resistance has emerged.

TL;DR: The results encourage the use of Citrus peels, which is wasted in huge amounts, as cancer preventive food additives and as anticancer agents, without any conspicuous toxic symptoms.

TL;DR: Evaluating the effect of the extracts of water dropwort and its pharmacological molecules, hyperoside and isorhamnetin, on inflammatory response, especially inflammasome activation suggested them to be candidates to attenuate inflammaome inhibition.

TL;DR: The results of this study suggest that the tannin-rich extract from Ximenia americana var.

TL;DR: Berberine inhibits cell growth and migration by targeting ephrin-B2, and the inhibitory effects of berberine on ZR-75-30 cell proliferation and cell migration are confirmed.

TL;DR: Compounds 1-5 are valuable cytotoxic compounds that could be used to combat MDR cancer cells and Benzophenoe 5 is the most active molecule and deserve more investigations to develop new anticancer drugs.

TL;DR: The results demonstrated that COP induces apoptosis in HCT-116 cells through PI3K/Akt and mitochondrial-associated apoptotic pathway and suggest that COP has potential to be a therapeutic candidate for colon cancer patients.

TL;DR: Galangin (100mg/kg, p.o.) significantly ameliorated cisplatin induced nephrotoxicity by suppressing MAPK induced inflammation and apoptosis.

TL;DR: This review article aims to recapitulate different anticancer properties of SNG, and describes some of the molecular targets involved in exerting its effect, and depicts the pharmacokinetic and toxicological properties ofSNG.

TL;DR: The developed formulation strategy of nanosuspension could be exploited to improve the solubility and bio-availability of poorly soluble NN and other phytomedicines.

TL;DR: It was found that fargesin exhibits anti-inflammation effects on THP-1 cells via suppression of PKC pathway including downstream JNK, nuclear factors AP-1 and NF-ĸB, and the molecular mechanisms underlying them.

TL;DR: It is suggested that EGCG-antibiotic combinations might provide an alternative approach to treat infections with A. baumannii regardless of antibiotic resistance.

TL;DR: AMNQ is a potential antiproliferative natural compound that deserves more investigations to develop novel cytotoxic drugs against sensitive and MDR cancers, including MDR phenotypes.

TL;DR: Aloesin is found to ameliorates each phase of the wound healing process including inflammation, proliferation and remodeling through MAPK/Rho and Smad signaling pathways and indicates that aloesin has the therapeutic potential for treating cutaneous wounds.

TL;DR: It is shown that CPL extract possesses anti-inflammatory effect in mouse model of allergic airway inflammation by down-regulating IL-4, IL-5, eotaxin, TNF-α, NF-ĸB, and iNOS expression levels.

TL;DR: The findings indicate that EC induces mitochondrial-dependent apoptosis in HCC cells through ROS generation and p38 MAPK activation, making EC a promising candidate for further development as an anticancer agent for H CC cells.

TL;DR: EECP induced the expression of antioxidant-related genes, such as HO-1, GCLM, and GCLC, which has great implications for the potential of propolis to alleviate oxidative stress in wound tissues.

TL;DR: There is significant compositional variation among commercial finished products and two main causative quality problems were identified as adulteration by incorrect species or adulterated with food dyes.