14-3-3 proteins: a highly conserved, widespread family of eukaryotic proteins.
Alastair Aitken,D. B. Collinge,B. P. H. van Heusden,T. Isobe,Patrick H. Roseboom,G. Rosenfeld,Jürgen Soll +6 more
TLDR
A family of proteins known as 14-3-3 is currently receiving increased attention by investigators studying a broad range of biological systems, including plants and invertebrates, and current thinking indicates that these proteins may function as regulators in signal transduction/phosphorylation mechanisms.About:
This article is published in Trends in Biochemical Sciences.The article was published on 1992-12-01 and is currently open access. It has received 481 citations till now. The article focuses on the topics: Conserved sequence.read more
Citations
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Protein import into mitochondria.
TL;DR: Molecular chaperones in the matrix exert multiple functions in translocation, sorting, folding, and assembly of newly imported proteins.
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The 14-3-3 brain protein in cerebrospinal fluid as a marker for transmissible spongiform encephalopathies.
TL;DR: In patients with dementia, a positive immunoassay for the 14-3-3 brain protein in cerebrospinal fluid strongly supports a diagnosis of Creutzfeldt-Jakob disease, but this finding does not support the use of the test in patients without clinically evident dementia.
Journal ArticleDOI
The ins and outs of Raf kinases.
TL;DR: Signal-integrating enzymes that have the ability to switch tyrosine kinase signalling to serine/threonine phosphorylation and connect growth factor receptors with transcription factors and mediates transformation by most oncogenes are studied.
Journal ArticleDOI
P-Type ATPases
Michael G. Palmgren,Poul Nissen +1 more
TL;DR: The atomic structure of P-type ATPases in different conformations, together with ample mutagenesis evidence, has provided detailed insights into the pumping mechanism by these biological nanomachines.
References
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Five distinct calcium and phospholipid binding proteins share homology with lipocortin I.
R B Pepinsky,Richard Tizard,R J Mattaliano,Lesley K. Sinclair,G T Miller,Jeffrey L. Browning,E P Chow,C Burne,K S Huang,D Pratt +9 more
TL;DR: Two 35-kDa proteins from rat peritoneal lavages that inhibit phospholipase A2 activity are purified and it is confirmed that they are lipocortin-related, and the two inhibitors are referred to aslipocortins III and V.
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Protein kinase C--a family affair.
Peter J. Parker,Gurdip Kour,Richard Marais,Fiona Mitchell,Catherine J. Pears,Dick Schaap,Silvia Stabel,Catherine Webster +7 more
TL;DR: Characterization of the activities of some of these proteins in vitro shows that there are functional differences with respect to both their regulation and substrate specificity, which indicates that each member of this family may play a unique role in signal transduction.
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Brain 14-3-3 protein is an activator protein that activates tryptophan 5-monooxygenase and tyrosine 3-monooxygenase in the presence of Ca2+,calmodulin-dependent protein kinase II
TL;DR: The finding that the 14‐3‐3 protein is substantially identical to the ‘activator’ protein that activates tryptophan 5‐monooxygenase and tyrosine 3‐monono oxygengenase in the presence of Ca2+,calmodulin dependent protein kinase II suggests that it plays a role in the regulation of serotonin and noradrenaline biosynthesis in brain.
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The Drosophila EGF receptor homolog (DER) gene is allelic to faint little ball, a locus essential for embryonic development
Eyal D. Schejter,Ben-Zion Shilo +1 more
TL;DR: Recessive lethal mutations in the genetic locus of the Drosophila EGF receptor homolog (DER) were isolated and were shown to be allelic to the previously described locus faint little ball.
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Identification of four phosphorylation sites in the N-terminal region of tyrosine hydroxylase.
TL;DR: The data establish that the initiator methionine is removed by post-translational processing to leave pro-2 as the amino-terminus of the mature protein in tyrosine hydroxylase.