Open AccessJournal Article
14-3-3 proteins: an important regulator of autophagy in diseases.
TLDR
The role of 14-3-3 proteins in the control of autophagy in cancer, neurodegenerative diseases and other pathological conditions is summarized.Abstract:
Autophagy is a cell digestion process that determines cell fate by promoting cell survival or inducing cell death in a cell context-dependent manner. Several classical signaling pathways, such as phosphoinositide-3-kinase and mammalian target of rapamycin, tightly regulate autophagy. 14-3-3 proteins regulate various signaling pathways by phosphorylation-dependent binding with partner proteins. 14-3-3 proteins also regulate autophagy by binding with autophagy-related proteins such as Beclin-1 and hVPS34. This review summarizes the role of 14-3-3 proteins in the control of autophagy in cancer, neurodegenerative diseases and other pathological conditions.read more
Citations
More filters
Journal ArticleDOI
LRRK2 Biology from structure to dysfunction: research progresses, but the themes remain the same
TL;DR: Current knowledge of the basic biochemistry and cellular function of LRRK2 is summarized to paint a picture of a research field that in many ways is moving forward with great momentum, but in other ways has not changed fundamentally.
Journal ArticleDOI
Identification of Novel Lipid Droplet Factors that Regulate Lipophagy and Cholesterol Efflux in Macrophage Foam Cells
Sabrina Robichaud,Garrett Fairman,Viyashini Vijithakumar,Esther Mak,David P. Cook,David P. Cook,Alexander R. Pelletier,Sylvain Huard,Barbara C. Vanderhyden,Barbara C. Vanderhyden,Daniel Figeys,Mathieu Lavallée-Adam,Kristin Baetz,Mireille Ouimet +13 more
TL;DR: This study is the first to systematically identify several LD-associated proteins of the lipophagy machinery, a finding with important biological and therapeutic implications that may represent a novel strategy to treat atherosclerosis.
Journal ArticleDOI
Neural stem cell small extracellular vesicle-based delivery of 14-3-3t reduces apoptosis and neuroinflammation following traumatic spinal cord injury by enhancing autophagy by targeting Beclin-1.
Yuluo Rong,Wei Liu,Chengtang Lv,Jiaxing Wang,Yongjun Luo,Dongdong Jiang,Linwei Li,Zheng Zhou,Wei Zhou,Qingqing Li,Guoyong Yin,Lipeng Yu,Jin Fan,Weihua Cai +13 more
TL;DR: The results indicate that 14-3-3t acts via a newly-discovered mechanism for the activation of autophagy by NSC-sEVs, further promoting functional behavior recovery following spinal cord injury.
Journal ArticleDOI
The role of 14-3-3 proteins in cell signalling pathways and virus infection
Jiaqi Liu,Shengliang Cao,Guofei Ding,Bin Wang,Yingchao Li,Yuzhong Zhao,Qingyuan Shao,Jian Feng,Sidang Liu,Liting Qin,Yihong Xiao +10 more
TL;DR: The biological functions of 14‐3‐3 proteins in protein trafficking, cell‐cycle control, apoptosis, autophagy and other cell signal transduction pathways, as well as the associated mechanisms are summarized.
Journal ArticleDOI
Quantitative Subcellular Proteomics of the Orbitofrontal Cortex of Schizophrenia Patients.
Erika Velasquez,Daniel Martins-de-Souza,Daniel Martins-de-Souza,Ingrid Velásquez,Gabriel Reis Alves Carneiro,Andrea Schmitt,Peter Falkai,Gilberto B. Domont,Fábio C. S. Nogueira +8 more
TL;DR: The activation of NF-kB is suggested as a possible pathway that links the deregulation of glutamate, calcium, apoptosis and the activation of the immune system in schizophrenia patients.
References
More filters
Journal ArticleDOI
Neuroprotective Effect of TAT-14-3-3ε Fusion Protein against Cerebral Ischemia/Reperfusion Injury in Rats
TL;DR: It is suggested that TAT-14-3-3ε can be efficiently transduced into brain and exert significantly protective effect against brain ischemic injury through inhibiting neuronal apoptosis and autophagic activation.
Journal ArticleDOI
Genome-wide analysis of autophagy-related genes in banana highlights MaATG8s in cell death and autophagy in immune response to Fusarium wilt
TL;DR: It is found that seven MaATG8s were commonly regulated by Foc, and the effect of 3-MA treatment could be rescued by exogenous salicylic acid, jasmonic acid and ethylene, indicating the involvement of autophagy-mediated plant hormones in banana resistance to Fusarium wilt.
Journal ArticleDOI
Akt, 14-3-3ζ, and vimentin mediate a drug-resistant invasive phenotype in diffuse large B-cell lymphoma.
TL;DR: It is shown that chemical inhibition of Akt overcomes CHOP resistance in DLBCL cells, and activation of an Akt–14-3-3ζ signaling pathway in promoting a multidrug-resistant phenotype associated with a vimentin-dependent invasive behavior in DL BCL cells.
Journal ArticleDOI
14-3-3 Proteins SGF14c and SGF14l Play Critical Roles during Soybean Nodulation
Osman Radwan,Xia Wu,Manjula Govindarajulu,Marc Libault,David J. Neece,Man-Ho Oh,R. Howard Berg,Gary Stacey,Christopher G. Taylor,Steven C. Huber,Steven J. Clough +10 more
TL;DR: In this article, RNA interference was employed to silence SGF14c expression in soybean roots using Agrobacterium rhizogenes-mediated root transformation using B. japonicum inoculation, and transcriptomic, proteomic and cytological data suggest a critical role of one or both of these 14-3-3 proteins in early development stages of soybean nodules.
Journal ArticleDOI
Identification of different isoforms of 14-3-3 protein family in human dermal and epidermal layers
Ruhangiz T. Kilani,Abelardo Medina,Alastair Aitken,Reza B. Jalili,Matthew J. Carr,Aziz Ghahary +5 more
TL;DR: All members of 14-3-3 proteins are expressed by cells of epidermal but not dermal layer of skins and that these proteins are mainly expressed by differentiated keratinocytes.