Open AccessJournal Article
14-3-3 proteins: an important regulator of autophagy in diseases.
TLDR
The role of 14-3-3 proteins in the control of autophagy in cancer, neurodegenerative diseases and other pathological conditions is summarized.Abstract:
Autophagy is a cell digestion process that determines cell fate by promoting cell survival or inducing cell death in a cell context-dependent manner. Several classical signaling pathways, such as phosphoinositide-3-kinase and mammalian target of rapamycin, tightly regulate autophagy. 14-3-3 proteins regulate various signaling pathways by phosphorylation-dependent binding with partner proteins. 14-3-3 proteins also regulate autophagy by binding with autophagy-related proteins such as Beclin-1 and hVPS34. This review summarizes the role of 14-3-3 proteins in the control of autophagy in cancer, neurodegenerative diseases and other pathological conditions.read more
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LRRK2 Biology from structure to dysfunction: research progresses, but the themes remain the same
TL;DR: Current knowledge of the basic biochemistry and cellular function of LRRK2 is summarized to paint a picture of a research field that in many ways is moving forward with great momentum, but in other ways has not changed fundamentally.
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Identification of Novel Lipid Droplet Factors that Regulate Lipophagy and Cholesterol Efflux in Macrophage Foam Cells
Sabrina Robichaud,Garrett Fairman,Viyashini Vijithakumar,Esther Mak,David P. Cook,David P. Cook,Alexander R. Pelletier,Sylvain Huard,Barbara C. Vanderhyden,Barbara C. Vanderhyden,Daniel Figeys,Mathieu Lavallée-Adam,Kristin Baetz,Mireille Ouimet +13 more
TL;DR: This study is the first to systematically identify several LD-associated proteins of the lipophagy machinery, a finding with important biological and therapeutic implications that may represent a novel strategy to treat atherosclerosis.
Journal ArticleDOI
Neural stem cell small extracellular vesicle-based delivery of 14-3-3t reduces apoptosis and neuroinflammation following traumatic spinal cord injury by enhancing autophagy by targeting Beclin-1.
Yuluo Rong,Wei Liu,Chengtang Lv,Jiaxing Wang,Yongjun Luo,Dongdong Jiang,Linwei Li,Zheng Zhou,Wei Zhou,Qingqing Li,Guoyong Yin,Lipeng Yu,Jin Fan,Weihua Cai +13 more
TL;DR: The results indicate that 14-3-3t acts via a newly-discovered mechanism for the activation of autophagy by NSC-sEVs, further promoting functional behavior recovery following spinal cord injury.
Journal ArticleDOI
The role of 14-3-3 proteins in cell signalling pathways and virus infection
Jiaqi Liu,Shengliang Cao,Guofei Ding,Bin Wang,Yingchao Li,Yuzhong Zhao,Qingyuan Shao,Jian Feng,Sidang Liu,Liting Qin,Yihong Xiao +10 more
TL;DR: The biological functions of 14‐3‐3 proteins in protein trafficking, cell‐cycle control, apoptosis, autophagy and other cell signal transduction pathways, as well as the associated mechanisms are summarized.
Journal ArticleDOI
Quantitative Subcellular Proteomics of the Orbitofrontal Cortex of Schizophrenia Patients.
Erika Velasquez,Daniel Martins-de-Souza,Daniel Martins-de-Souza,Ingrid Velásquez,Gabriel Reis Alves Carneiro,Andrea Schmitt,Peter Falkai,Gilberto B. Domont,Fábio C. S. Nogueira +8 more
TL;DR: The activation of NF-kB is suggested as a possible pathway that links the deregulation of glutamate, calcium, apoptosis and the activation of the immune system in schizophrenia patients.
References
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MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB
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Chaperone-mediated autophagy: a unique way to enter the lysosome world
Susmita Kaushik,Ana Maria Cuervo +1 more
TL;DR: The characteristics of chaperone-mediated autophagy are reviewed and the subset of molecules that confer cells the capability to identify individual cytosolic proteins and direct them across the lysosomal membrane for degradation are reviewed.
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Autophagy, amyloidogenesis and Alzheimer disease
TL;DR: The combination of increased autophagy induction and defective clearance of Aβ-generating autophagic vacuoles creates conditions favorable for Aβ accumulation in Alzheimer disease.
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Akt-Mediated Regulation of Autophagy and Tumorigenesis Through Beclin 1 Phosphorylation
Richard C. Wang,Yongjie Wei,Z. H. An,Zhongju Zou,Guanghua Xiao,Govind Bhagat,Michael A. White,Julia Reichelt,Beth Levine +8 more
TL;DR: It is shown that Beclin 1, an essential autophagy and tumor suppressor protein, is a target of the protein kinase Akt, and Akt-mediated phosphorylation of BeClin 1 functions in Autophagy inhibition, oncogenesis, and the formation of an autophile-inhibitory BeclIn 1/14-3-3/vimentin intermediate filament complex.