7-Methylxanthine methyltransferase of coffee plants. Gene isolation and enzymatic properties.
TLDR
The results suggest that, in coffee plants, caffeine is synthesized through three independent methylation steps from xanthosine, in which CaMXMT catalyzes the second step to produce theobromine.About:
This article is published in Journal of Biological Chemistry.The article was published on 2001-03-16 and is currently open access. It has received 137 citations till now. The article focuses on the topics: Caffeine synthase & Xanthosine.read more
Citations
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Alkaloid Biosynthesis: Metabolism and Trafficking
Jörg Ziegler,Peter J. Facchini +1 more
TL;DR: The application of genomics to the alkaloid field has accelerated the discovery of cDNAs encoding previously elusive biosynthetic enzymes, and technologies, such as large-scale gene expression analyses and metabolic engineering approaches with transgenic plants, have provided new insights into the regulatory architecture of alkaloids metabolism.
Journal ArticleDOI
The coffee genome provides insight into the convergent evolution of caffeine biosynthesis
Lorenzo Carretero-Paulet,Alexis Dereeper,Gaëtan Droc,Romain Guyot,Marco Pietrella,Chunfang Zheng,Adriana Alberti,François Anthony,G. Aprea,Jean-Marc Aury,Pascal Bento,Maria Bernard,Stéphanie Bocs,Claudine Campa,Alberto Cenci,Alberto Cenci,Marie Christine Combes,Dominique Crouzillat,Corinne Da Silva,Loretta Daddiego,Fabien De Bellis,Stéphane Dussert,Olivier Garsmeur,Thomas Gayraud,Valentin Guignon,Katharina Jahn,Katharina Jahn,Véronique Jamilloux,Thierry Joët,Karine Labadie,Tianying Lan,Tianying Lan,Julie Leclercq,Maud Lepelley,Thierry Leroy,Leiting Li,Pablo Librado,Loredana Lopez,Adriana Muñoz,Adriana Muñoz,Benjamin Noel,Alberto Pallavicini,Gaetano Perrotta,Valérie Poncet,David Pot,Priyono,Michel Rigoreau,Mathieu Rouard,Julio Rozas,Christine Tranchant-Dubreuil,Robert VanBuren,Qiong Zhang,Alan Carvalho Andrade,Xavier Argout,Benoît Bertrand,Alexandre de Kochko,Giorgio Graziosi,Giorgio Graziosi,Robert J Henry,Jayarama,Ray Ming,Chifumi Nagai,Steve Rounsley,David Sankoff,Giovanni Giuliano,Victor A. Albert,Patrick Wincker,Patrick Wincker,Patrick Wincker,Philippe Lashermes +69 more
TL;DR: The Coffea canephora (coffee) genome was sequenced and identified a conserved gene order, and comparative analyses of caffeine NMTs demonstrate that these genes expanded through sequential tandem duplications independently of genes from cacao and tea, suggesting that caffeine in eudicots is of polyphyletic origin.
Journal ArticleDOI
Caffeine and related purine alkaloids: biosynthesis, catabolism, function and genetic engineering.
TL;DR: Information is presented on metabolic engineering that has produced coffee seedlings with reduced caffeine content, and transgenic caffeine-producing tobacco plants with enhanced disease resistance and evidence for the involvement of caffeine in chemical defense and allelopathy is discussed.
Journal ArticleDOI
S-Adenosyl-l-methionine: Beyond the universal methyl group donor
TL;DR: This review aims to summarize the present knowledge of catalytic roles of AdoMet in plant metabolism.
Journal ArticleDOI
Caffeine: a well known but little mentioned compound in plant science
Hiroshi Ashihara,Alan Crozier +1 more
TL;DR: The cloning of caffeine biosynthesis genes opens up the possibility of using genetic engineering to produce naturally decaffeinated tea and coffee.
References
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Book
Biochemistry & Molecular Biology of Plants
TL;DR: This edition of Biochemistry & Molecular Biology of Plants holds a unique place in the plant sciences literature as it provides the only comprehensive, authoritative, integrated single volume book in this essential field of study.
Journal ArticleDOI
Developmental Regulation of Methyl Benzoate Biosynthesis and Emission in Snapdragon Flowers
Natalia Dudareva,Lisa M. Murfitt,Craig J. Mann,Nina M. Gorenstein,Natalia Kolosova,Christine M. Kish,Connie C. Bonham,Karl V. Wood +7 more
TL;DR: Linear regression analysis revealed that production of methyl benzoate is regulated by the amount of benzoic acid and theamount of BAMT protein, which in turn is regulated at the transcriptional level.
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Synthesis of small heat-shock proteins is part of the developmental program of late seed maturation.
TL;DR: It is demonstrated that class I sHSPs are expressed during Arabidopsis seed development in a pattern similar to that previously observed in other species: they are first detected during mid-maturation, are most abundant in dry seeds, and decline rapidly during germination.
BookDOI
S-adenosylmethionine-dependent methyltransferases : structures and functions
Xiaodong Cheng,Robert Blumenthal +1 more
TL;DR: This invaluable volume, written by an international group of scientists, presents an overview of the AdoMet-dependent methyltransferases, with special emphasis on structure-function relationships.
Journal ArticleDOI
Rapid systemic accumulation of transcripts encoding a tobacco WRKY transcription factor upon wounding.
TL;DR: The results indicate that WIZZ is a new transcription factor which participates in early stages of the wound response, and specifically binds to sequences containing two TTGAC core motifs that are separated by a spacer of appropriate length.
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Caffeine: a well known but little mentioned compound in plant science
Hiroshi Ashihara,Alan Crozier +1 more