A BODIPY-Based Fluorescent Probe to Visually Detect Phosgene: Toward the Development of a Handheld Phosgene Detector.
TL;DR: A prototypical handheld phosGene detector with a promising sensing capability that expedites the detection of gaseous phosgene without sophisticated instrumentation was developed and involves a rapid response period suitable for issuing early warnings during emergency situations.
Abstract: A boron-dipyrromethene (BODIPY)-based fluorescent probe with a phosgene-specific reactive motif shows remarkable selectivity toward phosgene, in the presence of which the nonfluorescent dye rapidly transforms into a new structure and induces a fluorescent response clearly observable to the naked eye under ultraviolet light. Given that dynamic, a prototypical handheld phosgene detector with a promising sensing capability that expedites the detection of gaseous phosgene without sophisticated instrumentation was developed. The proposed method using the handheld detector involves a rapid response period suitable for issuing early warnings during emergency situations.
Summary (1 min read)
- Shows remarkable selectivity toward phosgene, in the presence of which the nonfluorescent dye rapidly transforms into a new structure and induces a fluorescent response clearly observable to the naked eye under ultraviolet light.
- The need for its detection is critical not only to protect civilians against terrorist plots, but also to alert workers to its leakage in industrial plants.
- For the spectral investigation, the authors used triphosgene as a comparatively safe phosgene source, which instantly transforms into phosgene in the presence of tertiary amines.
Synthesis of BOD-SYR
- The reaction mixture was heated at reflux under.
- The liquid phases residue was purified by column chromatography.
Synthesis of BOD-UREA
- Then, triphosgene solution (125 mm in dry DCM) was added drop by drop to the BOD-SYR solution under Ar for 10 min.
- After evaporation of solvent, the resultant residue was purified by column chromatography (2:1 hexane/ethyl acetate) to afford BOD-UREA (3 mg, 26 % yield).
Conflict of interest
- The authors declare no conflict of interest.
- For more details see the Supporting Information. .
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Q1. What are the contributions mentioned in the paper "A bodipy**-based fluorescent probe to visually detect phosgene: toward the development of a handheld phosgene detector" ?
In general, detecting phosgene with a molecular probe involves trapping the molecule using a reactive site ( e. g., hydroxy and amine functional groups ), which, following structural modification, generates a detectable optical signal, for example a colour change or fluorescence emission. Dr. U. H. Yildiz Inovasens Co. İzmir Technology Development Zone Inc. Teknopark, 35430 Urla, İzmir ( Turkey ) [ * * ] boron-dipyrromethene Supporting information and the ORCID identification number ( s ) for the author ( s ) of this article can be found under https: //doi. org/10.