Journal ArticleDOI
A Fluorescent Sensor for Dual-Channel Discrimination between Phosgene and a Nerve-Gas Mimic
TLDR
A o-phenylenediamine-pyronin linked dye that is capable of both fluorogenic and colorimetric discrimination between phosgene and the prototypical nerve-agent mimic, diethyl chlorophosphate (DCP) in the solution or gas phase is designed.Abstract:
The ability to analyze highly toxic chemical warfare agents (CWAs) and related chemicals in a rapid and precise manner is essential in order to alleviate serious threats to humankind and public security caused by unexpected terrorist attacks and industrial accidents. In this investigation, we designed a o-phenylenediamine-pyronin linked dye that is capable of both fluorogenic and colorimetric discrimination between phosgene and the prototypical nerve-agent mimic, diethyl chlorophosphate (DCP) in the solution or gas phase. Moreover, this dye has been used to construct a portable kit that can be employed for real-time monitoring of DCP and phosgene in the field, both in a discriminatory manner, and in a simple and safe way.read more
Citations
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Journal ArticleDOI
Fluorescent Chemosensors with Varying Degrees of Intramolecular Charge Transfer for Detection of a Nerve Agent Mimic in Solutions and in Vapor
TL;DR: Six 6-aminoquinolines with various N-substituents as chemosensors for a nerve-agent mimic diethylchlorophosphate (DCP) and the effects of the ICT character on the sensing property have been clarified.
Journal ArticleDOI
Fluorescent Chemosensors for Various Analytes Including Reactive Oxygen Species, Biothiol, Metal Ions, and Toxic Gases
TL;DR: The history of chemosensors is introduced, a review of studies that have been carried out, and the targets for these sensors vary from metal ions, anions, reactive oxygen/nitrogen species, biothiols, and toxic gases.
Journal ArticleDOI
An AIE-based fluorescent test strip for the portable detection of gaseous phosgene
TL;DR: An AIE-based fluorescent test strip (OPD-TPE-Py-2CN) for rapid and sensitive detection of gaseous phosgene was designed and the detection limit is lower than the "harmless" level of human response to acute phosGene exposure.
Journal ArticleDOI
Molecular Rotors for the Detection of Chemical Warfare Agent Simulants
TL;DR: The fluorogenic probe o-OH is able to detect and quantify organophosphorus nerve agent mimics in solution and in the vapor phase following immobilization on a solid substrate, making the system a suitable candidate for the field detection of chemical warfare agents.
Journal ArticleDOI
Colorimetric and Ratiometric Chemosensor for Visual Detection of Gaseous Phosgene Based on Anthracene Carboxyimide Membrane.
TL;DR: An anthracene carboxyimide-based chemosensor (AC-Phos) is reported for colorimetric and ratiometric fluorescence detection of highly toxic phosgene with a high selectivity and a low detection limit (2.3 nM).
References
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New Strategies for Fluorescent Probe Design in Medical Diagnostic Imaging
TL;DR: Although MRI, US, and x-ray CT are often listed as molecular imaging modalities, in truth, radionuclide and optical imaging are the most practical modalities for molecular imaging, because of their sensitivity and the specificity for target detection.
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Prognostic factors for local recurrence, metastasis, and survival rates in squamous cell carcinoma of the skin, ear, and lip : implications for treatment modality selection
TL;DR: All studies since 1940 on the prognosis of squamous cell carcinoma of the skin and lip are reviewed, finding local recurrences occur less frequently when SCC is treated by Mohs micrographic surgery.
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Decontamination of chemical warfare agents
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Dissolution of cholesterol gallstones by chenodeoxycholic acid.
TL;DR: Chenodeoxycholic acid may offer medical treatment for cholesterol cholelithiasis in man and the ratio of bile acids and lecithin to cholesterol in bile increased in all patients.
Journal ArticleDOI
Fluorescent Detection of Chemical Warfare Agents: Functional Group Specific Ratiometric Chemosensors
Shi-Wei Zhang,Timothy M. Swager +1 more
TL;DR: Indicators providing highly sensitive and functional group specific fluorescent response to diisopropyl fluorophosphate (DFP, a nerve gas (G-agent) simulant) are reported.