Journal ArticleDOI
A Fluorescent Sensor for Dual-Channel Discrimination between Phosgene and a Nerve-Gas Mimic
TLDR
A o-phenylenediamine-pyronin linked dye that is capable of both fluorogenic and colorimetric discrimination between phosgene and the prototypical nerve-agent mimic, diethyl chlorophosphate (DCP) in the solution or gas phase is designed.Abstract:
The ability to analyze highly toxic chemical warfare agents (CWAs) and related chemicals in a rapid and precise manner is essential in order to alleviate serious threats to humankind and public security caused by unexpected terrorist attacks and industrial accidents. In this investigation, we designed a o-phenylenediamine-pyronin linked dye that is capable of both fluorogenic and colorimetric discrimination between phosgene and the prototypical nerve-agent mimic, diethyl chlorophosphate (DCP) in the solution or gas phase. Moreover, this dye has been used to construct a portable kit that can be employed for real-time monitoring of DCP and phosgene in the field, both in a discriminatory manner, and in a simple and safe way.read more
Citations
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Journal ArticleDOI
Wireless Hazard Badges to Detect Nerve-Agent Simulants.
TL;DR: In this article, a single-use wearable hazard badge that dosimetrically detects diethylchlorophosphate (DCP), a model organophosphorous cholinesterase inhibitor simulant, is presented.
Journal ArticleDOI
A colorimetric and ratiometric fluorescent probe with ultralow detection limit and high selectivity for phosgene sensing
TL;DR: A colorimetric and ratiometric fluorescent probe (AC-6ED) with anthracene carboximide as fluorophore and ethylenediamine group as recognition moiety has been developed for phosgene detection in solutions and in the gas phase based on the intramolecular charge transfer (ICT) mechanism as discussed by the authors.
Journal ArticleDOI
Readily prepared iminocoumarin for rapid, colorimetric and ratiometric fluorescent detection of phosgene
TL;DR: This probe is based on a readily prepared and highly fluorescent iminocoumarin, which reacts rapidly with phosgene to form a cyclic carbamate product to produce, distinctive colorimetric and ratiometric fluorescent signal changes.
Journal ArticleDOI
Handy ratiometric detection of gaseous nerve agents with AIE-fluorophore-based solid test strips
TL;DR: A ratiometric fluorescent test-strip sensor (DPA-TPE-Py) for rapid, sensitive and selective detection of the gaseous nerve agent simulant diethyl chlorophosphate (DCP) has been developed as discussed by the authors.
Journal ArticleDOI
An ultrasensitive fluorescent probe for phosgene detection in solution and in air
TL;DR: In this article, an ultrasensitive fluorescent turn-on probe (HBT-Phos) for rapid detection of the highly toxic phosgene is reported, which uses 2-(2′-hydroxyphenyl)benzothiazole(HBT), a well-known excited-state intramolecular proton transfer (ESIPT) dye as the fluorophore and an oxime moiety as the reaction site.
References
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New Strategies for Fluorescent Probe Design in Medical Diagnostic Imaging
TL;DR: Although MRI, US, and x-ray CT are often listed as molecular imaging modalities, in truth, radionuclide and optical imaging are the most practical modalities for molecular imaging, because of their sensitivity and the specificity for target detection.
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Prognostic factors for local recurrence, metastasis, and survival rates in squamous cell carcinoma of the skin, ear, and lip : implications for treatment modality selection
TL;DR: All studies since 1940 on the prognosis of squamous cell carcinoma of the skin and lip are reviewed, finding local recurrences occur less frequently when SCC is treated by Mohs micrographic surgery.
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Decontamination of chemical warfare agents
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Dissolution of cholesterol gallstones by chenodeoxycholic acid.
TL;DR: Chenodeoxycholic acid may offer medical treatment for cholesterol cholelithiasis in man and the ratio of bile acids and lecithin to cholesterol in bile increased in all patients.
Journal ArticleDOI
Fluorescent Detection of Chemical Warfare Agents: Functional Group Specific Ratiometric Chemosensors
Shi-Wei Zhang,Timothy M. Swager +1 more
TL;DR: Indicators providing highly sensitive and functional group specific fluorescent response to diisopropyl fluorophosphate (DFP, a nerve gas (G-agent) simulant) are reported.