Journal ArticleDOI
A Fluorescent Sensor for Dual-Channel Discrimination between Phosgene and a Nerve-Gas Mimic
TLDR
A o-phenylenediamine-pyronin linked dye that is capable of both fluorogenic and colorimetric discrimination between phosgene and the prototypical nerve-agent mimic, diethyl chlorophosphate (DCP) in the solution or gas phase is designed.Abstract:
The ability to analyze highly toxic chemical warfare agents (CWAs) and related chemicals in a rapid and precise manner is essential in order to alleviate serious threats to humankind and public security caused by unexpected terrorist attacks and industrial accidents. In this investigation, we designed a o-phenylenediamine-pyronin linked dye that is capable of both fluorogenic and colorimetric discrimination between phosgene and the prototypical nerve-agent mimic, diethyl chlorophosphate (DCP) in the solution or gas phase. Moreover, this dye has been used to construct a portable kit that can be employed for real-time monitoring of DCP and phosgene in the field, both in a discriminatory manner, and in a simple and safe way.read more
Citations
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Journal ArticleDOI
Fluorescent and Colorimetric Chemosensors for Anions, Metal Ions, Reactive Oxygen Species, Biothiols, and Gases
TL;DR: In this article, the contributions of colorimetric and fluorescent chemosensors in detecting anions, metal ions, reactive oxygen species (ROS), reactive nitrogen species, biothiols, and gases are discussed.
Journal ArticleDOI
Smart hydrogel sensor for detection of organophosphorus chemical warfare nerve agents
Craig M. Whitaker,Eleanor E. Derouin,Morgan B. O'Connor,Claire K. Whitaker,Jacob A. Whitaker,Jordan J. Snyder,Noelle R. Kaufmann,Ashley N. Gilliard,Allison K. Reitmayer +8 more
TL;DR: In this paper, a novel "turn-off" fluorescence, smart hydrogel sensor for detection of a nerve agent simulant has been developed and tested and demonstrated an extremely fast and select fluorescence quenching detection response to the Sarin simulant diethylchlorophosphate (DCP) in aqueous and vapor phases.
Journal ArticleDOI
Development of BINOL-Si complexes with large stokes shifts and their application as chemodosimeters for nerve agent
TL;DR: In this article, three fluorescent BINOL-Si complexes (FS1, FS2 and FS3) were designed and synthesized to detect diethyl chlorophosphate (DCP), a mimic of lethal nerve agents.
Journal ArticleDOI
A Powerful Turn-On Fluorescent Probe for Phosgene: A Primary Amide Strategically Attached to an Anthracene Fluorophore
Journal ArticleDOI
Two-phase activated colorimetric and ratiometric fluorescent sensor for visual detection of phosgene via AIE coupled TICT processes.
TL;DR: In this article, an excellent colorimetric and ratiometric fluorescent sensor DPA-CI was developed by incorporated a diphenylamine (DPA) and a 2-imine-3-benzo[d]imidazole as the enhanced push-pull electronic structure into the coumarin fluorophore matrix.
References
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New Strategies for Fluorescent Probe Design in Medical Diagnostic Imaging
TL;DR: Although MRI, US, and x-ray CT are often listed as molecular imaging modalities, in truth, radionuclide and optical imaging are the most practical modalities for molecular imaging, because of their sensitivity and the specificity for target detection.
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Prognostic factors for local recurrence, metastasis, and survival rates in squamous cell carcinoma of the skin, ear, and lip : implications for treatment modality selection
TL;DR: All studies since 1940 on the prognosis of squamous cell carcinoma of the skin and lip are reviewed, finding local recurrences occur less frequently when SCC is treated by Mohs micrographic surgery.
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Decontamination of chemical warfare agents
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Dissolution of cholesterol gallstones by chenodeoxycholic acid.
TL;DR: Chenodeoxycholic acid may offer medical treatment for cholesterol cholelithiasis in man and the ratio of bile acids and lecithin to cholesterol in bile increased in all patients.
Journal ArticleDOI
Fluorescent Detection of Chemical Warfare Agents: Functional Group Specific Ratiometric Chemosensors
Shi-Wei Zhang,Timothy M. Swager +1 more
TL;DR: Indicators providing highly sensitive and functional group specific fluorescent response to diisopropyl fluorophosphate (DFP, a nerve gas (G-agent) simulant) are reported.