Journal ArticleDOI
A Fluorescent Sensor for Dual-Channel Discrimination between Phosgene and a Nerve-Gas Mimic
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TLDR
A o-phenylenediamine-pyronin linked dye that is capable of both fluorogenic and colorimetric discrimination between phosgene and the prototypical nerve-agent mimic, diethyl chlorophosphate (DCP) in the solution or gas phase is designed.Abstract:
The ability to analyze highly toxic chemical warfare agents (CWAs) and related chemicals in a rapid and precise manner is essential in order to alleviate serious threats to humankind and public security caused by unexpected terrorist attacks and industrial accidents. In this investigation, we designed a o-phenylenediamine-pyronin linked dye that is capable of both fluorogenic and colorimetric discrimination between phosgene and the prototypical nerve-agent mimic, diethyl chlorophosphate (DCP) in the solution or gas phase. Moreover, this dye has been used to construct a portable kit that can be employed for real-time monitoring of DCP and phosgene in the field, both in a discriminatory manner, and in a simple and safe way.read more
Citations
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Chemodosimeter for Selective and Sensitive Chromogenic and Fluorogenic Detection of Mustard Gas for Real Time Analysis.
TL;DR: A novel chemosensor, 3,6-bis(dimethylamino)-9(10H)-acridine thione (1), that can detect mustard gas and its simulant by both chromogenic and fluorogenic methods is presented, and for the first time, a single probe was able to demonstrate the detection with unprecedented selectivity over most probable interferences.
Journal ArticleDOI
Highly selective and sensitive chromogenic detection of nerve agents (sarin, tabun and VX): a multianalyte detection approach
TL;DR: A novel strategy using ferrocenyl dye for highly selective chromogenic detection of all nerve agents using real-time visual detection with a lower limit of detection (below LD50) made the present protocol highly appealing and versatile.
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Rapid, specific, and ultrasensitive fluorogenic sensing of phosgene through an enhanced PeT mechanism
TL;DR: In this article, an enhanced PeT-based fluorogenic phosgene probe 1-CN was proposed, comprising a BODIPY fluorescence reporter, and a catechol quencher at the meso-position acting as the phosegene reaction site.
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Selectively instant-response nanofibers with a fluorescent chemosensor toward phosgene in gas phase
TL;DR: A novel molecular design of a fluorescent chemosensor together with its polymer nanofibrous membrane for instant response to gaseous phosgene is presented.
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Real nerve agent study assessing pyridyl reactivity: Selective fluorogenic and colorimetric detection of Soman and simulant
TL;DR: In this paper, a chemical probe is tested with live agents for the purpose of benchmarking fluorescent pyridyl-containing systems with actual nerve agents and simulants together, and the molecule showed selective fluorogenic and colorimetric detection of Soman (GD) and its simulant over other G-series nerve agents.
References
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New Strategies for Fluorescent Probe Design in Medical Diagnostic Imaging
TL;DR: Although MRI, US, and x-ray CT are often listed as molecular imaging modalities, in truth, radionuclide and optical imaging are the most practical modalities for molecular imaging, because of their sensitivity and the specificity for target detection.
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Prognostic factors for local recurrence, metastasis, and survival rates in squamous cell carcinoma of the skin, ear, and lip : implications for treatment modality selection
TL;DR: All studies since 1940 on the prognosis of squamous cell carcinoma of the skin and lip are reviewed, finding local recurrences occur less frequently when SCC is treated by Mohs micrographic surgery.
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Decontamination of chemical warfare agents
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Dissolution of cholesterol gallstones by chenodeoxycholic acid.
TL;DR: Chenodeoxycholic acid may offer medical treatment for cholesterol cholelithiasis in man and the ratio of bile acids and lecithin to cholesterol in bile increased in all patients.
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Fluorescent Detection of Chemical Warfare Agents: Functional Group Specific Ratiometric Chemosensors
Shi-Wei Zhang,Timothy M. Swager +1 more
TL;DR: Indicators providing highly sensitive and functional group specific fluorescent response to diisopropyl fluorophosphate (DFP, a nerve gas (G-agent) simulant) are reported.