Journal ArticleDOI
A Fluorescent Sensor for Dual-Channel Discrimination between Phosgene and a Nerve-Gas Mimic
TLDR
A o-phenylenediamine-pyronin linked dye that is capable of both fluorogenic and colorimetric discrimination between phosgene and the prototypical nerve-agent mimic, diethyl chlorophosphate (DCP) in the solution or gas phase is designed.Abstract:
The ability to analyze highly toxic chemical warfare agents (CWAs) and related chemicals in a rapid and precise manner is essential in order to alleviate serious threats to humankind and public security caused by unexpected terrorist attacks and industrial accidents. In this investigation, we designed a o-phenylenediamine-pyronin linked dye that is capable of both fluorogenic and colorimetric discrimination between phosgene and the prototypical nerve-agent mimic, diethyl chlorophosphate (DCP) in the solution or gas phase. Moreover, this dye has been used to construct a portable kit that can be employed for real-time monitoring of DCP and phosgene in the field, both in a discriminatory manner, and in a simple and safe way.read more
Citations
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Journal ArticleDOI
Rational design of a reversible fluorescent probe for sensing GSH in mitochondria
TL;DR: In this article , a reversible fluorescent probe (named GeP) was designed for sensing GSH based on the nucleophilic addition and dissociation of intracellular GSH to GeP. GeP showed a fast response time and a 20-fold fluorescence change toward GSH.
Journal ArticleDOI
A benzoxazole functionalized fluorescent probe for selective Fe3+ detection and intracellular imaging in living cells
TL;DR: Fluorescent imaging in living L929 and MG-63 cells offered a promising candidate for mapping Fe3+ in biological samples and a rhodamine based 2-aminobenzoxazole functionalized probe showed strong fluorescence emission and color change.
Journal ArticleDOI
Rapid and sensitive detection of nerve agent mimics by meso-substituted BODIPY piperazines as fluorescent chemosensors
TL;DR: In this paper, three meso-substituted BODIPY piperazines, BPA-1, bPA-2 and BPA3, have been prepared for rapid and sensitive detections of nerve agent simulants (DCP and DFP) in solutions and in gaseous phase.
Journal ArticleDOI
Acid is a potential interferent in fluorescent sensing of chemical warfare agent vapors
Sheng-Qiang Fan,Genevieve H. Dennison,Nicholas FitzGerald,Paul L. Burn,Ian R. Gentle,Paul E. Shaw +5 more
TL;DR: In this paper, the authors disentangle the response of pyridyl-containing sensing materials to acid-containing and acid-free Sarin and simulants, and provide strong evidence that care needs to be taken when interpreting the results of fluorescence-based solid-state sensing studies of G-series CWAs and their simulants.
Journal ArticleDOI
Multifunctional fluorescent probes "killing two birds with one stone" - recent progress and outlook
Ya-Lin Qi,Li-Li Chen,Long Guo,Yu-Yao Cao,Hai-Rong Wang,Yu-Shun Yang,Ya-Dong Lu,Hai-Liang Zhu +7 more
TL;DR: This review focused on the different functions, design principles, sensing mechanisms and biological applications of Multifunctional fluorescent probes, and highlighted the challenges and future research directions in this rapidly developing field.
References
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Journal ArticleDOI
New Strategies for Fluorescent Probe Design in Medical Diagnostic Imaging
TL;DR: Although MRI, US, and x-ray CT are often listed as molecular imaging modalities, in truth, radionuclide and optical imaging are the most practical modalities for molecular imaging, because of their sensitivity and the specificity for target detection.
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Prognostic factors for local recurrence, metastasis, and survival rates in squamous cell carcinoma of the skin, ear, and lip : implications for treatment modality selection
TL;DR: All studies since 1940 on the prognosis of squamous cell carcinoma of the skin and lip are reviewed, finding local recurrences occur less frequently when SCC is treated by Mohs micrographic surgery.
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Decontamination of chemical warfare agents
Journal ArticleDOI
Dissolution of cholesterol gallstones by chenodeoxycholic acid.
TL;DR: Chenodeoxycholic acid may offer medical treatment for cholesterol cholelithiasis in man and the ratio of bile acids and lecithin to cholesterol in bile increased in all patients.
Journal ArticleDOI
Fluorescent Detection of Chemical Warfare Agents: Functional Group Specific Ratiometric Chemosensors
Shi-Wei Zhang,Timothy M. Swager +1 more
TL;DR: Indicators providing highly sensitive and functional group specific fluorescent response to diisopropyl fluorophosphate (DFP, a nerve gas (G-agent) simulant) are reported.