Journal ArticleDOI
A Magnetofluorescent Carbon Dot Assembly as an Acidic H 2 O 2 -Driven Oxygenerator to Regulate Tumor Hypoxia for Simultaneous Bimodal Imaging and Enhanced Photodynamic Therapy
Qingyan Jia,Jiechao Ge,Weimin Liu,Xiuli Zheng,Shiqing Chen,Yongmei Wen,Hongyan Zhang,Pengfei Wang +7 more
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TLDR
The collective properties of the Mn‐CD assembly enable it to be utilized as an acidic H2O2‐driven oxygenerator to increase the oxygen concentration in hypoxic solid tumors for simultaneous bimodal FL/MR imaging and enhanced PDT.Abstract:
Recent studies indicate that carbon dots (CDs) can efficiently generate singlet oxygen (1 O2 ) for photodynamic therapy (PDT) of cancer. However, the hypoxic tumor microenvironment and rapid consumption of oxygen in the PDT process will severely limit therapeutic effects of CDs due to the oxygen-dependent PDT. Thus, it is becoming particularly important to develop a novel CD as an in situ tumor oxygenerator for overcoming hypoxia and substantially enhancing the PDT efficacy. Herein, for the first time, magnetofluorescent Mn-CDs are successfully prepared using manganese(II) phthalocyanine as a precursor. After cooperative self-assembly with DSPE-PEG, the obtained Mn-CD assembly can be applied as a smart contrast agent for both near-infrared fluorescence (FL) (maximum peak at 745 nm) and T1 -weighted magnetic resonance (MR) (relaxivity value of 6.97 mM-1 s-1 ) imaging. More interestingly, the Mn-CD assembly can not only effectively produce 1 O2 (quantum yield of 0.40) but also highly catalyze H2 O2 to generate oxygen. These collective properties of the Mn-CD assembly enable it to be utilized as an acidic H2 O2 -driven oxygenerator to increase the oxygen concentration in hypoxic solid tumors for simultaneous bimodal FL/MR imaging and enhanced PDT. This work explores a new biomedical use of CDs and provides a versatile carbon nanomaterial candidate for multifunctional nanotheranostic applications.read more
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Journal ArticleDOI
Innovative Strategies for Hypoxic-Tumor Photodynamic Therapy
TL;DR: These efforts have produced many innovative methods to avoid the limits of PDT associated with hypoxia, which are summarized in this review.
Journal ArticleDOI
Evolution and Synthesis of Carbon Dots: From Carbon Dots to Carbonized Polymer Dots
TL;DR: CPDs are revealed as an emerging class of CDs with distinctive polymer/carbon hybrid structures and properties, and critical insights into facilitating their potential in various application fields are proposed.
Journal ArticleDOI
Carbon Dots: A New Type of Carbon-Based Nanomaterial with Wide Applications
Junjun Liu,Rui Li,Bai Yang +2 more
TL;DR: This Outlook comprehensively summarize the classification of CDs based on the analysis of their formation mechanism, micro-/nanostructure and property features, and describe their synthetic methods and optical properties including strong absorption, photoluminescence, and phosphorescence.
Journal ArticleDOI
Photosensitizers for Photodynamic Therapy
TL;DR: The strategies to improve ROS generation through optimizing photoinduced electron transfer and energy transfer processes of PSs are highlighted and the approaches that combine PDT with other therapeutics and the targeted delivery in cancer cells or tumor tissue are introduced.
Journal ArticleDOI
Precise nanomedicine for intelligent therapy of cancer
Huabing Chen,Zhanjun Gu,An Hongwei,An Hongwei,Chunying Chen,Chunying Chen,Jie Chen,Jie Chen,Ran Cui,Siqin Chen,Wei-Hai Chen,Xuesi Chen,Xuesi Chen,Xiaoyuan Chen,Zhuo Chen,Baoquan Ding,Qian Dong,Qin Fan,Ting Fu,Da-Yong Hou,Qiao Jiang,Hengte Ke,Xiqun Jiang,Gang Liu,Suping Li,Tianyu Li,Zhuang Liu,Guangjun Nie,Muhammad Ovais,Muhammad Ovais,Dai-Wen Pang,Nasha Qiu,Youqing Shen,Huayu Tian,Huayu Tian,Chao Wang,Hao Wang,Zi-Qi Wang,Huaping Xu,Jiang Fei Xu,Xiangliang Yang,Shuang Zhu,Xianchuang Zheng,Xian-Zheng Zhang,Yanbing Zhao,Weihong Tan,Weihong Tan,Xi Zhang,Yuliang Zhao +48 more
TL;DR: The recent advances of intelligent cancer nanomedicine are demonstrated, and the comprehensive understanding of their structure-function relationship for smart and efficient cancer nanotechine including various imaging and therapeutic applications, as well as nanotoxicity is discussed.
References
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