α-Methylnoradrenaline induced hypotension and bradycardia after administration into the area of the nucleus tractus solitarii
Frans P. Nijkamp,Wybren de Jong +1 more
TLDR
Bilateral injections of α-methylnoradrenaline into the area of the nucleus tractus solitarii of the brain stem caused a dose-dependent decrease of systemic arterial blood pressure and heart rate of anesthetized rats.About:
This article is published in European Journal of Pharmacology.The article was published on 1975-06-01 and is currently open access. It has received 29 citations till now. The article focuses on the topics: Baroreceptor & Angiotensin II.read more
Citations
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Journal ArticleDOI
Chronic lability of arterial pressure produced by destruction of A2 catecholaminergic neurons in rat brainstem.
TL;DR: It is concluded that destruction of A2 neurons produces persistent lability and exaggerated reactivity of arterial pressure as a consequence of partial removal of the noradrenergic innervation of the nucleus tractus solitarii of the NTS, and the results suggest that nor adrenergic neurons of A1 serve to modulate baroreceptor reflexes in NTS.
Journal ArticleDOI
The hypotensive activity and side effects of methyldopa, clonidine, and guanfacine.
TL;DR: A discussion on the pharmacological basis of the side effects of the centrally acting antihypertensives has been limited to those adverse reactions that are somehow related to alpha-adrenergic receptors.
Journal ArticleDOI
Blood pressure responses to local application of serotonergic agents in the nucleus tractus solitarii
TL;DR: The present data suggest that enhancement of serotonergic activity in the region of the nucleus tractus solitarius produces a neurogenic pressor response.
Book ChapterDOI
Localization of catecholaminergic receptor sites in the nucleus tractus solitarii involved in the regulation of arterial blood pressure.
Zandberg P,De Jong W +1 more
TL;DR: It was found that the minimum effective dose of α-methylnoradrenaline in NTS region causing a hypotensive response after bilateral local application was 80 pmoles, and data suggest that the area of the NTS may be a site of action for central hypotensive drugs that act by adrenergic receptor stimulation in the brain.
References
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Journal ArticleDOI
Further evidence for a central hypotensive action of α-methyldopa in both the rat and cat
L. Finch,G. Haeusler +1 more
TL;DR: The results strongly suggest that the central actions of α‐methyldopa are important for its hypotensive effect, although a possible peripheral effect cannot be excluded.
Journal ArticleDOI
Evidence that the hypotensive action of methyldopa is mediated by central actions of methylnoradrenaline.
M. Henning,A. Rubenson +1 more
TL;DR: The formation ofα‐methylnoradrenaline from α‐MD was prevented after FLA‐63 but there was a significant increase in the amounts of α‐methyldopamine formed.
Journal ArticleDOI
Noradrenaline: central inhibitory control of blood pressure and heart rate.
TL;DR: The results suggest an inhibitory role of an α-adrenoceptor in the area of the nucleus tractus solitarii in the central control of blood pressure in anesthetized rats.
Journal ArticleDOI
α-sympathetic receptor stimulation in the brain and hypotensive activity of α-methyldopa
A. Heise,G. Kroneberg +1 more
TL;DR: It was concluded that α-methyldopa exerts its blood pressure decreasing effect at least partly by the stimulation of central α-sympathetic receptors.
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