α-Methylnoradrenaline induced hypotension and bradycardia after administration into the area of the nucleus tractus solitarii
Frans P. Nijkamp,Wybren de Jong +1 more
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Bilateral injections of α-methylnoradrenaline into the area of the nucleus tractus solitarii of the brain stem caused a dose-dependent decrease of systemic arterial blood pressure and heart rate of anesthetized rats.About:
This article is published in European Journal of Pharmacology.The article was published on 1975-06-01 and is currently open access. It has received 29 citations till now. The article focuses on the topics: Baroreceptor & Angiotensin II.read more
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Distribution of α2 agonist binding sites in the rat and human central nervous system: Analysis of some functional, anatomic correlates of the pharmacologic effects of clonidine and related adrenergic agents
TL;DR: These functional, anatomical and neurochemical correlates of the alpha 2 binding site distribution establish a neurological basis for the complex pharmacological effects of centrally acting alpha 2 agonists.
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Effect of catecholamine-receptor stimulating agents on blood pressure after local application in the nucleus tractus solitarii of the medulla oblongata.
TL;DR: The present data suggest that the catecholaminergic receptors in the A2-region of the NTS differ from the classic vascular alpha-receptor and that the NTS also may contain structures which can antagonize the decrease in blood pressure.
Journal ArticleDOI
Neurophysiology and neuropharmacology of cardiovascular regulation and stress
TL;DR: The conclusion is reached that further multidisciplinary research will reveal underlying neurophysiological and neuropharmacological mechanisms responsible for stress induced cardiovascular disease and lead to new methods of treatment.
Journal ArticleDOI
Centrally induced hypotension and bradycardia after administration of alpha-methylnoradrenaline into the area of the nucleus tractus solitarii of the rat.
W. De Jong,Frans P. Nijkamp +1 more
TL;DR: In anaesthetized rats, bilateral injections of α‐methylnoradrenaline, noradrenalin or adrenaline into the area of the nucleus tractus solitarii of the brain stem caused dose‐dependent decreases of systemic arterial blood pressure and heart rate.
Journal ArticleDOI
Chronic lability of arterial pressure produced by selective destruction of the catecholamine innervation of the nucleus tractus solitarii in the rat.
TL;DR: It is suggested that the catecholamine innervation of NTS modulates rather than mediates baroreceptor reflexes, serving to maintain arterial pressure within narrow limits.
References
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Central hypotensive effect of α-methyldopa
M. Henning,P. A. van Zwieten +1 more
TL;DR: In cats under chloralose anaesthesia l-α-methyldopa was infused for 1 hr into the left vertebral artery a gradual and significant lowering of mean arterial blood pressure was observed, and the dopamine and noradrenaline contents of the brain were significantly reduced while brain 5-hydroxytryptamine and heart nor adrenaline concentrations remained normal.
Journal ArticleDOI
Central inhibitory effect of α-methyldopa on blood pressure, heart rate and body temperature of renal hypertensive rats
TL;DR: It is suggested that in the renal hypertensive rat the decrease in blood pressure and in body temperature depends on a central action of alpha-methyldopa metabolites.
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