α-Methylnoradrenaline induced hypotension and bradycardia after administration into the area of the nucleus tractus solitarii
Frans P. Nijkamp,Wybren de Jong +1 more
TLDR
Bilateral injections of α-methylnoradrenaline into the area of the nucleus tractus solitarii of the brain stem caused a dose-dependent decrease of systemic arterial blood pressure and heart rate of anesthetized rats.About:
This article is published in European Journal of Pharmacology.The article was published on 1975-06-01 and is currently open access. It has received 29 citations till now. The article focuses on the topics: Baroreceptor & Angiotensin II.read more
Citations
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Distribution of α2 agonist binding sites in the rat and human central nervous system: Analysis of some functional, anatomic correlates of the pharmacologic effects of clonidine and related adrenergic agents
TL;DR: These functional, anatomical and neurochemical correlates of the alpha 2 binding site distribution establish a neurological basis for the complex pharmacological effects of centrally acting alpha 2 agonists.
Journal ArticleDOI
Effect of catecholamine-receptor stimulating agents on blood pressure after local application in the nucleus tractus solitarii of the medulla oblongata.
TL;DR: The present data suggest that the catecholaminergic receptors in the A2-region of the NTS differ from the classic vascular alpha-receptor and that the NTS also may contain structures which can antagonize the decrease in blood pressure.
Journal ArticleDOI
Neurophysiology and neuropharmacology of cardiovascular regulation and stress
TL;DR: The conclusion is reached that further multidisciplinary research will reveal underlying neurophysiological and neuropharmacological mechanisms responsible for stress induced cardiovascular disease and lead to new methods of treatment.
Journal ArticleDOI
Centrally induced hypotension and bradycardia after administration of alpha-methylnoradrenaline into the area of the nucleus tractus solitarii of the rat.
W. De Jong,Frans P. Nijkamp +1 more
TL;DR: In anaesthetized rats, bilateral injections of α‐methylnoradrenaline, noradrenalin or adrenaline into the area of the nucleus tractus solitarii of the brain stem caused dose‐dependent decreases of systemic arterial blood pressure and heart rate.
Journal ArticleDOI
Chronic lability of arterial pressure produced by selective destruction of the catecholamine innervation of the nucleus tractus solitarii in the rat.
TL;DR: It is suggested that the catecholamine innervation of NTS modulates rather than mediates baroreceptor reflexes, serving to maintain arterial pressure within narrow limits.
References
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Further evidence for a central hypotensive action of α-methyldopa in both the rat and cat
L. Finch,G. Haeusler +1 more
TL;DR: The results strongly suggest that the central actions of α‐methyldopa are important for its hypotensive effect, although a possible peripheral effect cannot be excluded.
Journal ArticleDOI
Evidence that the hypotensive action of methyldopa is mediated by central actions of methylnoradrenaline.
M. Henning,A. Rubenson +1 more
TL;DR: The formation ofα‐methylnoradrenaline from α‐MD was prevented after FLA‐63 but there was a significant increase in the amounts of α‐methyldopamine formed.
Journal ArticleDOI
Noradrenaline: central inhibitory control of blood pressure and heart rate.
TL;DR: The results suggest an inhibitory role of an α-adrenoceptor in the area of the nucleus tractus solitarii in the central control of blood pressure in anesthetized rats.
Journal ArticleDOI
α-sympathetic receptor stimulation in the brain and hypotensive activity of α-methyldopa
A. Heise,G. Kroneberg +1 more
TL;DR: It was concluded that α-methyldopa exerts its blood pressure decreasing effect at least partly by the stimulation of central α-sympathetic receptors.
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