α-Methylnoradrenaline induced hypotension and bradycardia after administration into the area of the nucleus tractus solitarii
Frans P. Nijkamp,Wybren de Jong +1 more
TLDR
Bilateral injections of α-methylnoradrenaline into the area of the nucleus tractus solitarii of the brain stem caused a dose-dependent decrease of systemic arterial blood pressure and heart rate of anesthetized rats.About:
This article is published in European Journal of Pharmacology.The article was published on 1975-06-01 and is currently open access. It has received 29 citations till now. The article focuses on the topics: Baroreceptor & Angiotensin II.read more
Citations
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Journal ArticleDOI
α-Methyldopa induces a naltrexone-insensitive antinociception and hypomotility in rats
Paul L.M. van Giersberge,Paul L.M. van Giersberge,Elizabeth van Duinkerken,C.G.J. (Fred) Sweep,Victor M. Wiegant,Jan M. van Ree,Wybren de Jong,Wybren de Jong +7 more
TL;DR: The results indicate that endogenous opioid peptides are involved in the hypotensive action of α‐methyldopa but not in β‐endorphin‐like immunoreactivity in plasma and cerebrospinal fluid and antinociception.
Journal ArticleDOI
Selective stimulation of central alpha-autoreceptors following treatment with alpha-methyldopa and FLA 136.
TL;DR: The α-adrenoreceptor blocking agent yohimbine increased the nialamide-induced accumulation of normetanephrine and completely antagonized the actions ofα-methyldopa and FLA 136, indicating that the effects of the two drugs are due to stimulation of α- adrenoreceptors.
Book ChapterDOI
Centrally Acting Drugs as a Tool to Study Central Mechanisms of Blood Pressure Control
W. Hoefke,W. Gaida +1 more
TL;DR: The importance of adrenergic and of serotonergic mechanisms and of gamma-amino-butyric acid in regulating blood pressure is reviewed in this article using centrally acting antihypertensive agents as tools.
Journal ArticleDOI
Contrasting subcellular responses to monohydroxytamoxifen and oestradiol benzoate in the immature rat uterus [proceedings].
C. J. Dix,Virgil Craig Jordan +1 more
TL;DR: Monohydroxytamoxifen can stimulate a rise in rat uterine progesterone receptor content but, unlike oestradiol benzoate, cannot increase uterine DNA content or epithelial cell division.
References
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Journal ArticleDOI
Further evidence for a central hypotensive action of α-methyldopa in both the rat and cat
L. Finch,G. Haeusler +1 more
TL;DR: The results strongly suggest that the central actions of α‐methyldopa are important for its hypotensive effect, although a possible peripheral effect cannot be excluded.
Journal ArticleDOI
Evidence that the hypotensive action of methyldopa is mediated by central actions of methylnoradrenaline.
M. Henning,A. Rubenson +1 more
TL;DR: The formation ofα‐methylnoradrenaline from α‐MD was prevented after FLA‐63 but there was a significant increase in the amounts of α‐methyldopamine formed.
Journal ArticleDOI
Noradrenaline: central inhibitory control of blood pressure and heart rate.
TL;DR: The results suggest an inhibitory role of an α-adrenoceptor in the area of the nucleus tractus solitarii in the central control of blood pressure in anesthetized rats.
Journal ArticleDOI
α-sympathetic receptor stimulation in the brain and hypotensive activity of α-methyldopa
A. Heise,G. Kroneberg +1 more
TL;DR: It was concluded that α-methyldopa exerts its blood pressure decreasing effect at least partly by the stimulation of central α-sympathetic receptors.
Related Papers (5)
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Nobutaka Doba,Donald J. Reis +1 more
Topographic atlas of catecholamine and acetylcholinesterase-containing neurons in the rat brain. I. Forebrain (telencephalon, diencephalon).
Evidence for the existence of monoamine-containing neurons in the central nervous system. i. demonstration of monoamines in the cell bodies of brain stem neurons.
Dahlstroem A,Fuxe K +1 more