Journal ArticleDOI
A new nonenzymatic method and device to obtain a fat tissue derivative highly enriched in pericyte-like elements by mild mechanical forces from human lipoaspirates.
Francesca Bianchi,Margherita Maioli,Margherita Maioli,Erika Leonardi,Elena Olivi,Elena Olivi,Gianandrea Pasquinelli,Sabrina Valente,Armando J. Mendez,Camillo Ricordi,Mirco Raffaini,Carlo Tremolada,Carlo Ventura,Carlo Ventura +13 more
TLDR
The features of fresh product were retained in the Lipogems product obtained from human cadavers, paving the way to an off-the-shelf strategy for reconstructive procedures and regenerative medicine.About:
This article is published in Cell Transplantation.The article was published on 2013-11-01. It has received 252 citations till now. The article focuses on the topics: Adipose tissue & Mesenchymal stem cell.read more
Citations
More filters
Journal ArticleDOI
Adipose stem cells: biology and clinical applications for tissue repair and regeneration.
TL;DR: The regenerative properties of ASCs that can be harnessed for clinical applications are discussed, current and future challenges for ASC clinical use are explored, and such challenges include knowledge-based deficiencies, hurdles for translating research to the clinic, and barriers to establishing a new paradigm of medical care.
Journal ArticleDOI
Prevascularization in tissue engineering: Current concepts and future directions.
TL;DR: An overview of current strategies for the generation of preformed microvascular networks within tissue constructs and their adaptation to individual therapeutic interventions will markedly contribute to a broad implementation of tissue engineering applications into clinical practice.
Journal ArticleDOI
Adipose Tissue and Mesenchymal Stem Cells: State of the Art and Lipogems® Technology Development
TL;DR: Lipogems® technology is emerging as a valid intraoperative system to obtain an optimal final product that may be used immediately for regenerative purposes, and several clinical trials are under way to support the initial encouraging outcomes.
Journal ArticleDOI
Adult Mesenchymal Stem Cells: When, Where, and How
TL;DR: The medicine of tomorrow will encompass optimizing the tissues' intrinsic regenerative potential through management of local MSCs, as well as addressing other tissue dysfunctions and diseases.
Journal ArticleDOI
Challenges in Clinical Development of Mesenchymal Stromal/Stem Cells: Concise Review
Ilenia Mastrolia,Elisabetta Manuela Foppiani,Alba Murgia,Olivia Candini,Anna Valeria Samarelli,Giulia Grisendi,Elena Veronesi,Edwin M. Horwitz,Massimo Dominici +8 more
TL;DR: The aim was to dissect the current challenges in the development of still promising cell types that, after more than half a century, still need to reach their maturity.
References
More filters
Journal ArticleDOI
A new mathematical model for relative quantification in real-time RT-PCR.
TL;DR: This study enters into the particular topics of the relative quantification in real-time RT-PCR of a target gene transcript in comparison to a reference gene transcript and presents a new mathematical model that needs no calibration curve.
Journal ArticleDOI
Multilineage cells from human adipose tissue: implications for cell-based therapies.
Patricia A. Zuk,Min Zhu,Hiroshi Mizuno,Jerry I. Huang,Futrell Jw,Adam J. Katz,Prosper Benhaim,H. P. Lorenz,Marc H. Hedrick +8 more
TL;DR: The data support the hypothesis that a human lipoaspirate contains multipotent cells and may represent an alternative stem cell source to bone marrow-derived MSCs.
Journal ArticleDOI
Human Adipose Tissue Is a Source of Multipotent Stem Cells
Patricia A. Zuk,Min Zhu,Peter Ashjian,Daniel A. De Ugarte,Jerry I. Huang,Hiroshi Mizuno,Zeni Alfonso,John K. Fraser,Prosper Benhaim,Marc H. Hedrick +9 more
TL;DR: To confirm whether adipose tissue contains stem cells, the PLA population and multiple clonal isolates were analyzed using several molecular and biochemical approaches and PLA cells exhibited unique characteristics distinct from those seen in MSCs, including differences in CD marker profile and gene expression.
Journal ArticleDOI
Mesenchymal stem cells as trophic mediators.
Arnold I. Caplan,James E. Dennis +1 more
TL;DR: Several studies which tested the use of MSCs in models of infarct (injured heart), stroke (brain), or meniscus regeneration models are reviewed within the context of M SC‐mediated trophic effects in tissue repair.
Journal ArticleDOI
Secretion of Angiogenic and Antiapoptotic Factors by Human Adipose Stromal Cells
Jalees Rehman,Dmitry O. Traktuev,Jingling Li,Stephanie Merfeld-Clauss,Constance J. Temm-Grove,Jason E. Bovenkerk,Carrie L. Pell,Brian H. Johnstone,Robert V. Considine,Keith L. March +9 more
TL;DR: The findings suggest that autologous delivery of either native or transduced subcutaneous ASCs, which are regulated by hypoxia, may be a novel therapeutic option to enhance angiogenesis or achieve cardiovascular protection.