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Book ChapterDOI

A Novel Double Fault Diagnosis and Detection Technique in Digital Microfluidic Biochips

TL;DR: The proposed algorithm detects double faults anywhere in the chip satisfying the dynamic fluidic constraints and improves the fault diagnosis time to an extent.
Abstract: This paper presents a rigorous offline double fault diagnosis as well as a detection technique for Digital Microfluidic Biochips (DMFBs). Due to the underlying mixed technology biochips exhibit unique failure mechanisms and defects. Thus, offline and online test mechanisms are required to certify the dependability of the system. In this paper, the proposed algorithm detects double faults anywhere in the chip satisfying the dynamic fluidic constraints and improves the fault diagnosis time to an extent.

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Citations
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Journal ArticleDOI
TL;DR: An efficient fault detection mechanism is formulated to identify multiple numbers of defective/faulty electrodes on an m × n biochip array, where m and n can be of any positive number.
Abstract: The involvement of Digital Microfluidic Biochips (DMFBs) in the field of disease detection, automated drug discovery, on-chip DNA (Deoxyribonucleic acid) analysis has become well-accepted d...

3 citations


Cites background or methods from "A Novel Double Fault Diagnosis and ..."

  • ...Three major components in a biochip are 2Dmicrofluidic array, dispensing ports/reservoirs, and optical detectors [12] (see Figure 1)....

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  • ...Multiple and double fault detection techniques have been proposed in [11] and [12], respectively, by Chowdhury et al....

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Journal ArticleDOI
TL;DR: An aspect of fast fault diagnosis appliance for perceiving double faults and recognizing the fault locations within the biochip is introduced and the suggested result outpoured that the propound technique is competent, efficacious as well as delineate signifying improvement over the surviving method.
Abstract: Progress of digital microfluidic biochip (DMFB) confronts for the defective and specious electrodes. Not only these hinder the routing of droplets but also the completion time of assay is influenced by those defective electrodes. As Microfluidic-based biochips are broadly used in the revolution of medical diagnosis, gigantic parallel DNA analysis, automatic drug discovery and real-time biomolecular recognition including numerous safety-critical applications, this biochip definitely responsible for appropriate and accurate result. Prior accepting it for perceptive purposes the microfluidic biochip must confirm its precision and robustness. In this article, an aspect of fast fault diagnosis appliance for perceiving double faults and recognizing the fault locations within the biochip is introduced. If the biochip is defect free then the proposed approach computes the traversal time as well. The suggested result outpoured that the propound technique is competent, efficacious as well as delineate signifying improvement over the surviving method. Furthermore this paper added expedient reconfiguration contrivance.

2 citations


Cites background or methods from "A Novel Double Fault Diagnosis and ..."

  • ...Comparison of proposed technique with existing technique [23, 39]...

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  • ...diagnosis technique could be comprehended from [23]....

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  • ...Matrix Size Proposed Existing [23, 39] Improvement (%) 4×4 17 24 29....

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  • ...Next we have presented the comparative studies of the proposed technique with [23, 39], [22, 33] and [43] in Table 4, 5 and 6 respectively....

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  • ...On the other hand, multiple fault detection is not an indicative of intelligence; as detection of multiple faults is very intricate grind [23]....

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References
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Journal ArticleDOI
TL;DR: In this paper, the authors provide an in-depth look at the state-of-the-art in integrated microfludic devices for a broad range of application areas from on-chip DNA analysis, immunoassays and cytometry to advances in integrated detection technologies for and miniaturized fuel processing devices.

738 citations


"A Novel Double Fault Diagnosis and ..." refers background in this paper

  • ...An integrated microfluidic device incorporates many of the necessary components and functionality of a typical room-sized laboratory onto a small chip [1]....

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Proceedings ArticleDOI
02 Apr 2003
TL;DR: A microfluidic lab-on-chip (LoC) for measuring the concentration of human body metabolites, using submicroliter droplets as reaction chambers, is presented in this article.
Abstract: A microfluidic lab-on-chip (LoC) for measuring the concentration of human body metabolites, using submicroliter droplets as reaction chambers, is presented in this paper. The device is based on the manipulation of droplets using the principle of electrowetting and is integrated with an optical absorbance measurement system for detection. We have demonstrated the detection of glucose using a colorimetric enzyme-kinetic assay in less than 40 seconds. The sensor response is linear in the range of 25mg/dl to 300mg/dl, with less than 5% deviation from linearity at the upper limit. In addition to glucose, we have also demonstrated the feasibility of lactate, glutamate, and pyruvate assays using our system.

169 citations


"A Novel Double Fault Diagnosis and ..." refers background or methods in this paper

  • ...Microfluidic biochips have been characterized for the detection of faults [4], [5], [6], [7]....

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  • ...The test planning problem was formulated in terms of Euler circuit in [6], [7]....

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Journal ArticleDOI
TL;DR: In this article, a push-pull differential resonant accelerometer with double-ended-tuning-fork (DETF) as the inertial force sensor was designed and tested.
Abstract: We present the design, fabrication, and testing of a push-pull differential resonant accelerometer with double-ended-tuning-fork (DETF) as the inertial force sensor. The accelerometer is fabricated with the silicon-on-insulator microelectromechanical systems (MEMS) technology that bridges surface micromachining and bulk micromachining by integrating the 50-/spl mu/m-thick high-aspect ratio MEMS structure with the standard circuit foundry process. Two DETF resonators serve as the force sensor measuring the acceleration through a frequency shift caused by the inertial force acting as axial loading. Two-stage microleverage mechanisms with an amplification factor of 80 are designed for force amplification to increase the overall sensitivity to 160 Hz/g, which is confirmed by the experimental value of 158 Hz/g. Trans-resistance amplifiers are designed and integrated on the same chip for output signal amplification and processing. The 50-/spl mu/m thickness of the high-aspect ratio MEMS structure has no effect on the amplification factor of the mechanism but contributes to a greater capacitance force; therefore, the resonator can be actuated by a much lower ac voltage comparing to the 2-/spl mu/m-thick DETF resonators. The testing results agree with the designed sensitivity for static acceleration.

138 citations

Proceedings ArticleDOI
30 Sep 2003
TL;DR: This paper presents a costeffective concurrent test methodology for droplet-based microelectrofluidic systems, presents a classification of catastrophic and parametric faults in such systems and shows how faults can be detected by electrostatically controlling and tracking droplet motion.
Abstract: Composite microsystems that integrate mechanical and fluidic components are fast emerging as the next generation of system-on-chip designs. As these systems become widespread in safety-critical biomedical applications, dependability emerges as a critical performance parameter. In this paper, we present a costeffective concurrent test methodology for droplet-based microelectrofluidic systems. We present a classification of catastrophic and parametric faults in such systems and show how faults can be detected by electrostatically controlling and tracking droplet motion. We then present tolerance analysis based on Monte-Carlo simulations to characterize the impact of parameter variations on system performance. To the best of our knowledge, this constitutes the first attempt to define a fault model and to develop a test methodology for droplet-based microelectrofluidic systems.

127 citations


"A Novel Double Fault Diagnosis and ..." refers background in this paper

  • ...In [8], a functional testing has been proposed, referring to [4], [10], [11] that targets the functional operations of the microfluidic modules....

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  • ...Microfluidic biochips have been characterized for the detection of faults [4], [5], [6], [7]....

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  • ...As has been described in [4], faults in digital microfluidic systems can be classified as being either catastrophic or parametric....

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Journal ArticleDOI
TL;DR: A parallel scan-like testing methodology for digital microfluidic devices and a diagnosis method based on test outcomes is proposed, enhanced such that multiple defect sites can be efficiently located using parallel scan -like testing.
Abstract: Dependability is an important attribute for microfluidic biochips that are used for safety-critical applications such as point-of-care health assessment, air-quality monitoring, and food-safety testing. Therefore, these devices must be adequately tested after manufacture and during bioassay operations. We propose a parallel scan-like testing methodology for digital microfluidic devices. A diagnosis method based on test outcomes is also proposed. The diagnosis technique is enhanced such that multiple defect sites can be efficiently located using parallel scan-like testing. Defect diagnosis can be used to reconfigure a digital microfluidic biochip such that faults can be avoided, thereby enhancing chip yield and defect tolerance. We evaluate the proposed method using complexity analysis as well as applying it to a fabricated biochip.

123 citations


"A Novel Double Fault Diagnosis and ..." refers background or methods in this paper

  • ...An efficient diagnosis technique has been enhanced in [14] by...

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  • ...Time Slice Required % improvement in Diagnosis Existing [14] Proposed Case 1 Case 2 Case 3 (Min) (Max) Diagnosis Detection Diagnosis Detection (max) Diagnosis Detection 1 32 20 24 24 32 28 28 12....

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  • ...O(N), and compared to parallel scan-like test and multiple defect diagnosis [14], which has 8N steps, the time needed for this diagnosis is reduced....

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