Journal ArticleDOI
A novel nasal almotriptan loaded solid lipid nanoparticles in mucoadhesive in situ gel formulation for brain targeting: Preparation, characterization and in vivo evaluation.
Nancy Abdel Hamid Abou Youssef,Abeer Ahmed Kassem,Ragwa M. Farid,Fatma Ahmed Ismail,Magda A. El-Massik,Nabila Boraie +5 more
TLDR
Results revealed rapid ALM brain delivery of the optimized formula, and toxicological results confirmed the safety of NF for nasal administration, encouraging for further clinical trials of the developed system in humans in future research.About:
This article is published in International Journal of Pharmaceutics.The article was published on 2018-09-05. It has received 75 citations till now. The article focuses on the topics: Solid lipid nanoparticle.read more
Citations
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Journal ArticleDOI
Solid Lipid Nanoparticles for Drug Delivery: Pharmacological and Biopharmaceutical Aspects
TL;DR: The currently active clinical trials on lipid nanoparticles were reviewed, with a brief discussion on what achievements or milestones are still to be reached, as a way of understanding the reasons for the scarce number of solid lipid nanoparticle undergoing clinical trials.
Journal ArticleDOI
Stimuli-responsive In situ gelling system for nose-to-brain drug delivery.
Mukta Agrawal,Shailendra Saraf,Swarnlata Saraf,Sunil Kumar Dubey,Anu Puri,Umesh Gupta,Prashant Kesharwani,V. Ravichandiran,Pramod Kumar,Vegi Ganga Modi Naidu,Upadhyayula Suryanarayana Murty,Ajazuddin,Amit Alexander +12 more
TL;DR: The article is aimed to gather all the information of the past 10 years related to the development and application of stimuli-responsive in situ nasal gel for brain drug delivery.
Journal ArticleDOI
Intranasal delivery of nanostructured lipid carriers, solid lipid nanoparticles and nanoemulsions: A current overview of in vivo studies.
Cláudia Pina Costa,João Nuno Moreira,José Manuel Sousa Lobo,Ana Catarina Silva,Ana Catarina Silva +4 more
TL;DR: Although the exact mechanism of drug transport from the nose to the brain is not fully understood and its effectiveness in humans is unclear, it appears that the intranasal route together with the use of NLCs, SLNs or NEs is advantageous for targeting drugs to thebrain.
Journal ArticleDOI
Solid Lipid Nanoparticles: A Promising Nanomaterial in Drug Delivery.
TL;DR: SLNs have emerged as a promising nanomaterial for efficient delivery of various Active Pharmaceutical Ingredients (APIs) and have also shown great potential for delivery of gene/DNA, vaccines, as well as in cosmeceuticals.
Journal ArticleDOI
Revisiting the blood-brain barrier: A hard nut to crack in the transportation of drug molecules.
Seetha Harilal,Jobin Jose,Della Grace Thomas Parambi,Rajesh Kumar,Mazhuvancherry Kesavan Unnikrishnan,Md. Sahab Uddin,Githa Elizabeth Mathew,Rahul Pratap,Akash Marathakam,Bijo Mathew +9 more
TL;DR: The concluding section outlines contemporary trends in drug discovery, focusing on molecular determinants of BBB permeation and novel drug-delivery systems, such as dendrimers, liposomes, nanoparticles, nanogels, etc.
References
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Journal ArticleDOI
Solid lipid nanoparticles: Production, characterization and applications
W. Mehnert,Karsten Mäder +1 more
TL;DR: An overview about the selection of the ingredients, different ways of SLN production and SLN applications, and the in vivo fate of the carrier are presented.
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Statistics and Chemometrics for Analytical Chemistry
TL;DR: A recent visit to one of BP’s European technology centers produced a request to develop statistics training for the people in the analytical lab, so a search to see what books were available found this book, a husband and wife pairing of an analytical chemist and a statistician, hard to imagine a much better book for use as the first course with a group of analytical chemists.
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Design and Production of Nanoparticles Formulated From Nano-Emulsion Templates-A Review
TL;DR: A link between nano-emulsion formulation methods and nanoparticle generation is proposed, while at the same time bearing in mind the above-mentioned parameters for active molecule encapsulation.
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Nanostructured lipid matrices for improved microencapsulation of drugs
TL;DR: A special preparation process-applicable to NLC but also SLN-allows the production of highly concentrated particle dispersions (>30-95%).
Journal ArticleDOI
Intranasal delivery to the central nervous system: Mechanisms and experimental considerations
TL;DR: This review focuses on the current understanding of the mechanisms underlying intranasal delivery to the central nervous system involving the olfactory and trigeminal nerves, the vasculature, the cerebrospinal fluid, and the lymphatic system.