A quantitative description of membrane current and its application to conduction and excitation in nerve
A. L. Hodgkin,A. F. Huxley +1 more
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This article concludes a series of papers concerned with the flow of electric current through the surface membrane of a giant nerve fibre by putting them into mathematical form and showing that they will account for conduction and excitation in quantitative terms.Abstract:
This article concludes a series of papers concerned with the flow of electric current through the surface membrane of a giant nerve fibre (Hodgkinet al, 1952,J Physiol116, 424–448; Hodgkin and Huxley, 1952,J Physiol116, 449–566) Its general object is to discuss the results of the preceding papers (Section 1), to put them into mathematical form (Section 2) and to show that they will account for conduction and excitation in quantitative terms (Sections 3–6)read more
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References
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Potential, impedance, and rectification in membranes
TL;DR: A theoretical picture has been presented based on the use of the general kinetic equations for ion motion under the influence of diffusion and electrical forces and on a consideration of possible membrane structures that shows qualitative agreement with the rectification properties and very good agreementwith the membrane potential data.
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Currents carried by sodium and potassium ions through the membrane of the giant axon of Loligo
A. L. Hodgkin,A. F. Huxley +1 more
TL;DR: The identity of the ions which carry the various phases of the membrane current is chiefly concerned with sodium ions, since there is much evidence that the rising phase of the action potential is caused by the entry of these ions.
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Measurement of current-voltage relations in the membrane of the giant axon of Loligo.
TL;DR: The importance of ionic movements in excitable tissues has been emphasized by a number of recent experiments which are consistent with the theory that nervous conduction depends on a specific increase in permeability which allows sodium ions to move from the more concentrated solution outside a nerve fibre to the more dilute solution inside it.
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The dual effect of membrane potential on sodium conductance in the giant axon of Loligo
A. L. Hodgkin,A. F. Huxley +1 more
TL;DR: This paper contains a further account of the electrical properties of the giant axon of Loligo and deals with the 'inactivation' process which gradually reduces sodium permeability after it has undergone the initial rise associated with depolarization.