A quantitative description of membrane current and its application to conduction and excitation in nerve
A. L. Hodgkin,A. F. Huxley +1 more
Reads0
Chats0
TLDR
This article concludes a series of papers concerned with the flow of electric current through the surface membrane of a giant nerve fibre by putting them into mathematical form and showing that they will account for conduction and excitation in quantitative terms.Abstract:
This article concludes a series of papers concerned with the flow of electric current through the surface membrane of a giant nerve fibre (Hodgkinet al, 1952,J Physiol116, 424–448; Hodgkin and Huxley, 1952,J Physiol116, 449–566) Its general object is to discuss the results of the preceding papers (Section 1), to put them into mathematical form (Section 2) and to show that they will account for conduction and excitation in quantitative terms (Sections 3–6)read more
Citations
More filters
Journal ArticleDOI
Time Course of TEA+-Induced Anomalous Rectification in Squid Giant Axons
TL;DR: Changes in the voltage clamp currents of squid giant axons wrought by low axoplasmic TEA+ (tetraethylammonium chloride) concentrations (0.3 mM and above) are described and it is found that the channels cannot be closed by the normal voltage-sensitive mechanism until they are free of TEA+.
BookDOI
Model neural networks and behavior
TL;DR: One day, you will discover a new adventure and knowledge by spending more money, but when does this happen?
Journal ArticleDOI
Mathematical Frameworks for Oscillatory Network Dynamics in Neuroscience
TL;DR: In this article, a set of mathematical tools that are suitable for addressing the dynamics of oscillatory neural networks, broadening from a standard phase oscillator perspective to provide a practical framework for further successful applications of mathematics to understand network dynamics in neuroscience.
Journal ArticleDOI
Changes in conduction velocity during acute ischemia in ventricular myocardium of the isolated porcine heart
TL;DR: The time dependence of nonuniform propagation and the relatively high conduction velocities explain two major characteristics of reentrant tachycardias in acute ischemia: the large diameters of reENTrant circuits and the beat-to-beat changes in localization of conduction block.
Journal ArticleDOI
A quantitative analysis of the activation and inactivation kinetics of HERG expressed in Xenopus oocytes.
TL;DR: Simulations showed that modulation of inactivation is a minimal component of the increase of this current by [K+]o, and that a large increase in total conductance must also occur, as well as the existence of at least one relatively voltage‐insensitive step.
References
More filters
Journal ArticleDOI
Potential, impedance, and rectification in membranes
TL;DR: A theoretical picture has been presented based on the use of the general kinetic equations for ion motion under the influence of diffusion and electrical forces and on a consideration of possible membrane structures that shows qualitative agreement with the rectification properties and very good agreementwith the membrane potential data.
Journal ArticleDOI
Currents carried by sodium and potassium ions through the membrane of the giant axon of Loligo
A. L. Hodgkin,A. F. Huxley +1 more
TL;DR: The identity of the ions which carry the various phases of the membrane current is chiefly concerned with sodium ions, since there is much evidence that the rising phase of the action potential is caused by the entry of these ions.
Journal ArticleDOI
Measurement of current-voltage relations in the membrane of the giant axon of Loligo.
TL;DR: The importance of ionic movements in excitable tissues has been emphasized by a number of recent experiments which are consistent with the theory that nervous conduction depends on a specific increase in permeability which allows sodium ions to move from the more concentrated solution outside a nerve fibre to the more dilute solution inside it.
Journal ArticleDOI
The dual effect of membrane potential on sodium conductance in the giant axon of Loligo
A. L. Hodgkin,A. F. Huxley +1 more
TL;DR: This paper contains a further account of the electrical properties of the giant axon of Loligo and deals with the 'inactivation' process which gradually reduces sodium permeability after it has undergone the initial rise associated with depolarization.