A quantitative description of membrane current and its application to conduction and excitation in nerve
A. L. Hodgkin,A. F. Huxley +1 more
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This article concludes a series of papers concerned with the flow of electric current through the surface membrane of a giant nerve fibre by putting them into mathematical form and showing that they will account for conduction and excitation in quantitative terms.Abstract:
This article concludes a series of papers concerned with the flow of electric current through the surface membrane of a giant nerve fibre (Hodgkinet al, 1952,J Physiol116, 424–448; Hodgkin and Huxley, 1952,J Physiol116, 449–566) Its general object is to discuss the results of the preceding papers (Section 1), to put them into mathematical form (Section 2) and to show that they will account for conduction and excitation in quantitative terms (Sections 3–6)read more
Citations
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Voltage-dependent gating of Shaker A-type potassium channels in Drosophila muscle.
TL;DR: The voltage-dependent gating mechanism of A1-type potassium channels coded for by the Shaker locus of Drosophila was studied and it was concluded that all of the molecular transitions after first opening, including the inactivation transition, are voltage independent and therefore not associated with charge movement through the membrane.
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Developmental changes in Na+ conductances in rat neocortical neurons: appearance of a slowly inactivating component.
TL;DR: There are no kinetic differences in the Na+ channels between cell types in rat neocortical neurons and the observation that Na+ current inactivation occurs with two exponentials is verified.
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The hitchhiker’s guide to the voltage-gated sodium channel galaxy
TL;DR: The current understanding of Nav channel gating mechanisms, ion selectivity and permeation, and modulation by therapeutics and toxins are synthesized in light of the new structures of the prokaryotic Nav channels that, for the time being, serve as structural models of their eukaryotic counterparts.
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Allosteric Voltage Gating of Potassium Channels I: Mslo Ionic Currents in the Absence of Ca2+
TL;DR: A gating scheme where a central transition between a closed and an open conformation is allosterically regulated by the state of four independent and identical voltage sensors is understood, where the majority of the channel's voltage dependence results from rapid C-C and O-O states, whereas the C-O transitions are rate limiting and weakly voltage dependent.
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The slow passage through a Hopf bifurcation: delay, memory effects, and resonance
TL;DR: In this article, the authors explored analytically and numerically in the context of the FitzHugh-Nagumo model of nerve membrane excitability, and found that the transition is realized when the parameter is considerably beyond the value predicted from a straightforward bifurcation analysis which neglects; the dynamic aspect of the parameter variation.
References
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Potential, impedance, and rectification in membranes
TL;DR: A theoretical picture has been presented based on the use of the general kinetic equations for ion motion under the influence of diffusion and electrical forces and on a consideration of possible membrane structures that shows qualitative agreement with the rectification properties and very good agreementwith the membrane potential data.
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Currents carried by sodium and potassium ions through the membrane of the giant axon of Loligo
A. L. Hodgkin,A. F. Huxley +1 more
TL;DR: The identity of the ions which carry the various phases of the membrane current is chiefly concerned with sodium ions, since there is much evidence that the rising phase of the action potential is caused by the entry of these ions.
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Measurement of current-voltage relations in the membrane of the giant axon of Loligo.
TL;DR: The importance of ionic movements in excitable tissues has been emphasized by a number of recent experiments which are consistent with the theory that nervous conduction depends on a specific increase in permeability which allows sodium ions to move from the more concentrated solution outside a nerve fibre to the more dilute solution inside it.
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The dual effect of membrane potential on sodium conductance in the giant axon of Loligo
A. L. Hodgkin,A. F. Huxley +1 more
TL;DR: This paper contains a further account of the electrical properties of the giant axon of Loligo and deals with the 'inactivation' process which gradually reduces sodium permeability after it has undergone the initial rise associated with depolarization.