Journal ArticleDOI
Physiological role of silent receptors of atrial natriuretic factor
Thomas Maack,M. Suzuki,Fernando Almeida,Daniel R. Nussenzveig,Robert M. Scarborough,Glenn A. McEnroe,John A. Lewicki +6 more
TLDR
The results show that the majority of the renal receptors of ANF are biologically silent, and this new class of receptors may serve as specific peripheral storage-clearance binding sites, acting as a hormonal buffer system to modulate plasma levels of ANf.Abstract:
A ring-deleted analog of atrial natriuretic factor--des[Gln18, Ser19, Gly20, Leu21, Gly22] ANF4-23-NH2 (C-ANF4-23)--binds with high affinity to approximately 99% of ANF receptors in the isolated perfused rat kidney. In this preparation, C-ANF4-23 is devoid of detectable renal effects and does not antagonize any of the known renal hemodynamic and natriuretic actions of biologically active ANF1-28. In contrast, both C-ANF4-23 and ANF1-28 increase sodium excretion and decrease blood pressure in intact anesthetized rats. This apparent contradiction is resolved by the finding that the ring-deleted analog markedly increases plasma levels of endogenous immunoreactive ANF in the rat. The results show that the majority of the renal receptors of ANF are biologically silent. This new class of receptors may serve as specific peripheral storage-clearance binding sites, acting as a hormonal buffer system to modulate plasma levels of ANF.read more
Citations
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Journal ArticleDOI
Brain natriuretic peptide as a novel cardiac hormone in humans. Evidence for an exquisite dual natriuretic peptide system, atrial natriuretic peptide and brain natriuretic peptide.
Masashi Mukoyama,Kazumasa Nakao,Kiminori Hosoda,Shin Ichi Suga,Yoshihiko Saito,Yoshihiro Ogawa,Gotaro Shirakami,Michihisa Jougasaki,K Obata,Hirofumi Yasue +9 more
TL;DR: Results indicate that BNP is a novel cardiac hormone secreted predominantly from the ventricle, and that the synthesis, secretion and clearance of BNP differ from those of ANP, suggesting discrete physiological and pathophysiological roles of HBNP in a dual natriuretic peptide system.
Journal ArticleDOI
A membrane form of guanylate cyclase is an atrial natriuretic peptide receptor.
Michael Chinkers,David L. Garbers,Ming-Shi Chang,David G. Lowe,Hemin Chin,David V. Goeddel,Stephanie Schulz +6 more
TL;DR: The isolation, sequence and expression of a complementary DNA clone encoding the membrane form of guanylate cyclase from rat brain are reported, which represents a new class of mammalian cell-surface receptors which contain an extracellular ligand-binding domain and an intracellular guanyl cyclase catalytic domain.
Journal ArticleDOI
Natriuretic peptides, their receptors, and cyclic guanosine monophosphate-dependent signaling functions.
TL;DR: The structure, function, regulation, and biological consequences of natriuretic peptides and their associated signaling proteins are described.
Journal ArticleDOI
Cardiac natriuretic peptides act via p38 MAPK to induce the brown fat thermogenic program in mouse and human adipocytes.
Marica Bordicchia,Dianxin Liu,Ez-Zoubir Amri,Gérard Ailhaud,Paolo Dessì-Fulgheri,Chaoying Zhang,Nobuyuki Takahashi,Riccardo Sarzani,Sheila Collins +8 more
TL;DR: The ability of mammals to resist body fat accumulation is linked to their ability to expand the number and activity of brown-like adipocytes within white fat depots as mentioned in this paper, which can induce a functional “brown-like” adipocyte phenotype.
Journal ArticleDOI
Plasma Brain Natriuretic Peptide as an Indicator of Left Ventricular Systolic Function and Long-term Survival After Acute Myocardial Infarction Comparison With Plasma Atrial Natriuretic Peptide and N-Terminal Proatrial Natriuretic Peptide
Torbjørn Omland,A. Aakvaag,Vernon V. S. Bonarjee,Kenneth Caidahl,Rolv Terje Lie,Dennis W.T. Nilsen,Johan Sundsfjord,Kenneth Dickstein +7 more
TL;DR: Although plasma ANP appears to be a better predictor of left ventricular dysfunction, plasma BNP may have greater potential to complement standard prognostic indicators used in risk stratification after AMI because of its strong, independent association with long-term survival, enhanced in vitro stability, and simplicity of analysis.
References
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Journal ArticleDOI
Atrial natriuretic factor: a hormone produced by the heart
TL;DR: This hormone, described in 1981 as atrial natriuretic factor (ANF), is diuretic, hypotensive, and has an inhibitory effect on renin and aldosterone secretion.
Journal ArticleDOI
Atrial natriuretic factor elicits an endothelium-independent relaxation and activates particulate guanylate cyclase in vascular smooth muscle
Raymond J. Winquist,Elizabeth P. Faison,Scott A. Waldman,Karen Schwartz,Ferid Murad,Robert M. Rapoport +5 more
TL;DR: The direct (endothelium-independent) vasodilator effect of ANF may be mediated via increased tissue levels of cGMP via activation of particulate guanylate cyclase.
Journal ArticleDOI
Atriopeptins as cardiac hormones.
Philip Needleman,Steven Paul Adams,Barbara R. Cole,Mark G. Currie,David M. Geller,Marshall L. Michener,Clifford B. Saper,David S. Schwartz,David G. Standaert +8 more
TL;DR: This work treated atriopeptins as cardiac hormones as well as prolactin-like substances as a single substance as a treatment for atrial fibrillation in healthy adults.
Journal ArticleDOI
Effect of native and synthetic atrial natriuretic factor on cyclic GMP.
Pavel Hamet,Johanne Tremblay,Stephen C. Pang,Raul Garcia,Gaétan Thibault,Jolanta Gutkowska,Marc Cantin,Jacques Genest +7 more
TL;DR: During the course of ANF purification, the ANF-induced increase of cGMP production by kidney cells paralleled the heightened specific natriuretic activity of the atrial factor, and indirect inhibition of c GMP phosphodiesterase appears to participate in its effect.
Journal ArticleDOI
Ser-Leu-Arg-Arg-atriopeptin III: the major circulating form of atrial peptide.
David S. Schwartz,David M. Geller,Pamela T. Manning,Ned R. Siegel,Kam F. Fok,Christine E. Smith,Philip Needleman +6 more
TL;DR: Fractionation of plasma atriopeptin immunoreactivity by reverse-phase high-performance liquid chromatography showed that the major portion consists of two species of low molecular weight peptides in a ratio of 10 to 1, and both peaks exhibited potent vasorelaxant activity, suggesting the presence of the carboxyl terminal Phe-Arg sequence of atRIopeptin in each species.