Journal ArticleDOI
A review of the optical properties of biological tissues
TLDR
The known optical properties (absorption, scattering, total attenuation, effective attenuation and/or anisotropy coefficients) of various biological tissues at a variety of wavelengths are reviewed in this article.Abstract:
The known optical properties (absorption, scattering, total attenuation, effective attenuation, and/or anisotropy coefficients) of various biological tissues at a variety of wavelengths are reviewed. The theoretical foundations for most experimental approaches are outlined. Relations between Kubelka-Munk parameters and transport coefficients are listed. The optical properties of aorta, liver, and muscle at 633 nm are discussed in detail. An extensive bibliography is provided. >read more
Citations
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Calcium measurements in perfused mouse heart: quantitating fluorescence and absorbance of Rhod-2 by application of photon migration theory.
TL;DR: A ratiometric method using fluorescence and absorbance is validated as a measure of the quantum yield of calcium-dependent fluorescence, enabling determination of the dynamics of cytosolic calcium in the perfused mouse heart.
Journal ArticleDOI
Has Molecular and Cellular Imaging Enhanced Drug Discovery and Drug Development
Gang Niu,Xiaoyuan Chen +1 more
TL;DR: Several important applications of molecular and cellular imaging in drug discovery and development are discussed, which include: measurement of pharmacodynamic endpoints by imaging metabolism and proliferation, imaging angiogenic parameters, and imaging a particular pathway or downstream target.
Journal ArticleDOI
Co-localized confocal Raman spectroscopy and optical coherence tomography (CRS-OCT) for depth-resolved analyte detection in tissue.
Jason R. Maher,Oranat Chuchuen,Marcus H. Henderson,Sanghoon Kim,Matthew T. Rinehart,Angela D. M. Kashuba,Adam Wax,David F. Katz +7 more
TL;DR: The CRS-OCT instrument was used to accurately measure depth-resolved, physiologically-relevant concentrations of Tenofovir, a microbicide drug used to prevent the sexual transmission of HIV, in ex vivo tissue samples.
Journal ArticleDOI
Optical Wireless Power Transmission Using Si Photovoltaic Through Air, Water, and Skin
TL;DR: In this paper, the system efficiencies of optical wireless power transmissions through atmosphere, water, optical fiber, and human skin are numerically calculated and analyzed, assuming that the electrical-to-optical power conversion efficiency of laser diode to be 40% and does not have wavelength dependency.
Journal ArticleDOI
Sonophoric nanoprobe aided pH measurement in vivo using photoacoustic spectroscopy
TL;DR: The ability of the hydrophobic functional groups in the polyacrylamide matrix to shield the molecular dye from being affected by the proteins in the plasma, and prevent the dye from leaching out, is demonstrated.
References
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Journal ArticleDOI
The Optics of Human Skin
R. Rox Anderson,John A. Parrish +1 more
TL;DR: An integrated review of the transfer of optical radiation into human skin is presented, aimed at developing useful models for photomedicine.
Journal ArticleDOI
New contributions to the optics of intensely light-scattering materials.
TL;DR: In this paper, the Gurevic and Judd formulas were derived from the Kubelka-Munk differential equations, and they are exact under the same conditions as in this paper, that is, when the material is perfectly dull and when the light, is perfectly diffused or if it is parallel and hits the specimen under an angle of 60° from normal.
Journal ArticleDOI
Time resolved reflectance and transmittance for the non-invasive measurement of tissue optical properties.
TL;DR: A simple model is developed, based on the diffusion approximation to radiative transfer theory, which yields analytic expressions for the pulse shape in terms of the interaction coefficients of a homogeneous slab.
Journal ArticleDOI
The delta-Eddington approximation for radiative flux transfer
TL;DR: In this paper, the delta-Eddington approximation was used to calculate monochromatic radiative fluxes in an absorbing-scattering atmosphere, by combining a Dirac delta function and a two-term approximation, which overcomes the poor accuracy of the Eddington approximation for highly asymmetric phase functions.