A unique recognition site mediates the interaction of fibrinogen with the leukocyte integrin Mac-1 (CD11b/CD18).
Dario C. Altieri,Francisca R. Agbanyo,Janet Plescia,Mark H. Ginsberg,Thomas S. Edgington,Edward F. Plow +5 more
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TLDR
It is concluded that fibrinogen interacts with the leukocyte integrin Mac-1 through a novel recognition site that is not shared with other known integrins that function as fibr inogen receptors.About:
This article is published in Journal of Biological Chemistry.The article was published on 1990-07-25 and is currently open access. It has received 185 citations till now. The article focuses on the topics: Integrin alpha M & CD18.read more
Citations
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Journal ArticleDOI
Fibrinogen Stimulates Macrophage Chemokine Secretion Through Toll-Like Receptor 4
TL;DR: It is suggested that innate responses to fibrinogen and bacterial endotoxin may converge at the evolutionarily conserved Toll-like recognition molecules, thereby promoting immune surveillance at sites of inflammation.
Book ChapterDOI
Fibrinogen and Fibrin
TL;DR: The transglutaminase, Factor XIIIa, covalently binds specific glutamine residues in one fibrin molecule to lysine residues in another via isopeptide bonds, stabilizing the clot against mechanical, chemical, and proteolytic insults.
Journal ArticleDOI
Fibrin gels and their clinical and bioengineering applications
TL;DR: The biochemical and mechanical properties of fibrin have recently been exploited in numerous studies that suggest its potential for applications in medicine and bioengineering.
Journal ArticleDOI
The I domain is a major recognition site on the leukocyte integrin Mac-1 (CD11b/CD18) for four distinct adhesion ligands.
Michael S. Diamond,Julio Garcia-Aguilar,Joanna K. Bickford,Angel L. Corbí,Timothy A. Springer +4 more
TL;DR: It is found that the alpha subunit NH2-terminal region and divalent cation binding region, despite being separated by over 200 amino acids of the I domain, appear structurally apposed because three mAbs require the presence of both of these regions for antigenic reactivity, and chimeras that contain the NH2 terminus of p150,95 require the divalentCation binding regions of p 150,95 to associate firmly with the beta subunit.
Journal ArticleDOI
A subpopulation of Mac-1 (CD11b/CD18) molecules mediates neutrophil adhesion to ICAM-1 and fibrinogen.
TL;DR: A novel mAb (CBRM1/5) that binds to an activation-specific neoepitope on a subset of Mac-1 molecules on neutrophils and monocytes after stimulation with chemoattractants or phorobol esters but does not recognize Mac- 1 on resting myeloid cells is described.
References
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Journal ArticleDOI
New perspectives in cell adhesion : RGD and integrins
TL;DR: Together, the adhesion proteins and their receptors constitute a versatile recognition system providing cells with anchorage, traction for migration, and signals for polarity, position, differentiation, and possibly growth.
Journal ArticleDOI
Protein and cell membrane iodinations with a sparingly soluble chloroamide, 1,3,4,6-tetrachloro-3a,6a-diphrenylglycoluril.
Pamela J. Fraker,John C. Speck +1 more
TL;DR: The stability and sparing solubility of this chloroglycoluril in water can account for the minimal damage to proteins and living cells observed in these iodinations and allow for elimination of the reduction step employed at the close of iodinations with soluble chloroamides such as chloramine-T.
Journal ArticleDOI
Integrins: a family of cell surface receptors.
TL;DR: This brief review of sequence data from embryogenesis, thrombosis, and lymphocyte help and killing is summarized and attempts to clarify the relationships among the members of this family of cell surface receptors.
Journal ArticleDOI
Arg-Gly-Asp: a versatile cell recognition signal.
TL;DR: The RGD sequence as a basic unit of a widespread cellular recognition system is established and the same peptides also inhibit the attachment of fibroblasts to a number of other proteins, including vitronectin.
Journal Article
The role of the monocyte in atherogenesis: I. Transition of blood-borne monocytes into foam cells in fatty lesions.
TL;DR: The results indicate that blood mononuclear cells associated with lesion formation in this model are, in fact, monocytes, which subsequently undergo transformation into macrophage foam cells in fatty streak lesions.