Accelerated wound healing by injectable microporous gel scaffolds assembled from annealed building blocks
TLDR
An injectable, interconnected microporous gel scaffold assembled from annealed microgel building blocks whose chemical and physical properties can be tailored by microfluidic fabrication facilitated cell migration that resulted in rapid cutaneous-tissue regeneration and tissue-structure formation within five days.Abstract:
Injectable microporous scaffolds assembled from annealed microgel building blocks whose properties can be tailored by microfluidic fabrication facilitate rapid wound healing in vivo.read more
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Designing hydrogels for controlled drug delivery.
Jianyu Li,David J. Mooney +1 more
TL;DR: This Review discusses how different mechanisms interact and can be integrated to exert fine control in time and space over the drug presentation, and collects experimental release data from the literature and presents quantitative comparisons between different systems to provide guidelines for the rational design of hydrogel delivery systems.
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Antibacterial adhesive injectable hydrogels with rapid self-healing, extensibility and compressibility as wound dressing for joints skin wound healing.
TL;DR: In vivo experiments indicated that curcumin loaded hydrogels significantly accelerated wound healing rate with higher granulation tissue thickness and collagen disposition and upregulated vascular endothelial growth factor (VEGF) in a full-thickness skin defect model.
Journal ArticleDOI
Modeling Physiological Events in 2D vs. 3D Cell Culture.
Kayla Duval,Hannah Grover,Li-Hsin Han,Yongchao Mou,Adrian F. Pegoraro,Jeffery J. Fredberg,Zi Chen +6 more
TL;DR: 2D and 3D cell culture methods are reviewed, advantages and limitations of these techniques in modeling physiologically and pathologically relevant processes are discussed, and directions for future research are suggested.
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Emerging Droplet Microfluidics
TL;DR: The purpose of this review is to convey the fundamentals of droplet microfluidics, a critical analysis on its current status and challenges, and opinions on its future development.
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Mechanical forces direct stem cell behaviour in development and regeneration
Kyle H. Vining,David J. Mooney +1 more
TL;DR: Fundamental insights into the mechanobiology of stem cells also inform the design of artificial niches to support stem cells for regenerative therapies.
References
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Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering
TL;DR: Although modern synthetic biomaterials represent oversimplified mimics of natural ECMs lacking the essential natural temporal and spatial complexity, a growing symbiosis of materials engineering and cell biology may ultimately result in synthetic materials that contain the necessary signals to recapitulate developmental processes in tissue- and organ-specific differentiation and morphogenesis.
Journal ArticleDOI
Porous scaffold design for tissue engineering
TL;DR: The integration of CTD with SFF to build designer tissue-engineering scaffolds is reviewed and the mechanical properties and tissue regeneration achieved using designer scaffolds are details.
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Growth Factors, Matrices, and Forces Combine and Control Stem Cells
TL;DR: Multifaceted technologies are increasingly required to produce and interrogate cells ex vivo, to build predictive models, and, ultimately, to enhance stem cell integration in vivo for therapeutic benefit.
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Formation of dispersions using “flow focusing” in microchannels
TL;DR: In this paper, a flow-focusing geometry is integrated into a microfluidic device and used to study drop formation in liquid-liquid systems, where both monodisperse and polydisperse emulsions can be produced.
Journal ArticleDOI
The Design of Scaffolds for Use in Tissue Engineering. Part I. Traditional Factors
TL;DR: The authors analyze the factors necessary to enhance the design and manufacture of scaffolds for use in tissue engineering in terms of materials, structure, and mechanical properties and review the traditional scaffold fabrication methods.
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