Acceptability of oral solid medicines in older adults with and without dysphagia: A nested pilot validation questionnaire based observational study
TLDR
Assessment of acceptability of oral solid medicines in older ambulatory patients with and without dysphagia found that higher acceptability scores were seen in the dysphagic population than in the non-dysphagic population for all of the dosage forms that were easier to swallow than tablets and capsules.About:
This article is published in International Journal of Pharmaceutics.The article was published on 2016-10-30 and is currently open access. It has received 71 citations till now. The article focuses on the topics: Dysphagia & Population.read more
Figures
Table 1. Products used to represent 9 mm tablets in different shapes 
Table 2. Products used to represent various oral formulations 
Fig 3. Acceptability scores of different oral solid dosage forms (ODT: orally disintegrating tablet). 
Table 4. Participants’ impression on the flexible solid oral dosage forms. 2 
Figure 1. Percentage of participants selecting the tablet size and shape that started to cause difficulty in swallowing. 
Fig 2. Percentage of participants selecting the capsule size that might start to cause difficulty in swallowing
Citations
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Journal ArticleDOI
3D printed drug delivery and testing systems - a passing fad or the future?
TL;DR: An overview of the advantages and limitations of 3D printing for drug delivery and testing, as compared to traditional manufacturing techniques is provided.
Journal ArticleDOI
Patient acceptability of 3D printed medicines.
TL;DR: This study is the first to guide the pharmaceutical industry towards developing patient-centric medicine in different geometries via 3DP, with the highest acceptability scores for torus printlets indicating that FDM 3DP is a promising fabrication technology towards increasing patient acceptability of solid oral medicines.
Journal ArticleDOI
Patient acceptability, safety and access: A balancing act for selecting age-appropriate oral dosage forms for paediatric and geriatric populations.
TL;DR: This review provides a comprehensive and up-to-date analysis of oral dosage forms considering key aspects of formulation design including dosage considerations, ease of use, tolerability and safety, manufacturing complexity, stability, supply and cost.
Journal ArticleDOI
Patient Centric Pharmaceutical Drug Product Design-The Impact on Medication Adherence.
Enrica Menditto,Valentina Orlando,Giuseppe De Rosa,Paola Minghetti,Umberto M. Musazzi,Caitriona Cahir,Marta Kurczewska-Michalak,Przemyslaw Kardas,Elísio Costa,José Manuel Sousa Lobo,Isabel Almeida +10 more
TL;DR: Packaging, orodispersible formulations, fixed dose combinations products, multiparticulate formulations, topical formulations and 3D printing are of particular relevance in a PCDPD process and will be addressed in this review.
Journal ArticleDOI
3D printing technology as innovative solutions for biomedical applications.
TL;DR: This review condense the findings, summarize the improvements that are needed for the use of 3D printing in medicine, as well as plausible methods for creating medicines and medical devices in the future.
References
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Journal ArticleDOI
Medication administration in nursing homes
TL;DR: With the availability of most oral medicines as a liquid formulation, the majority of reported crushing or opening that is taking place is unnecessary and in many instances this is because of prescriber reluctance to change the prescription.
Journal ArticleDOI
Validation of the Sydney Swallow Questionnaire (SSQ) in a cohort of head and neck cancer patients
Raghav C. Dwivedi,Raghav C. Dwivedi,Suzanne St. Rose,Justin W. G. Roe,Justin W. G. Roe,Afroze S. Khan,Christopher Pepper,Christopher M. Nutting,Christopher M. Nutting,Peter Clarke,Cyrus Kerawala,Cyrus Kerawala,Peter Rhys-Evans,Peter Rhys-Evans,Kevin J. Harrington,Kevin J. Harrington,Rehan Kazi,Rehan Kazi +17 more
TL;DR: The Sydney Swallow Questionnaire is a precise, reliable and valid tool for assessing swallow in this patient group and is able to demonstrate the reliability and validity of the SSQ in HNC patients.
Journal ArticleDOI
Frequency of medication errors in primary care patients with polypharmacy
TL;DR: The frequency of medication errors is high in patients with polypharmacy in primary care and development of strategies (e.g. external medication review) is required to counteract medication errors.
Journal ArticleDOI
Regulatory perspectives on acceptability testing of dosage forms in children
TL;DR: The aim of this overview is to provide an update on current thinking and understanding of the problem, and discuss issues relating to the acceptability testing, which hopefully will result in a harmonised, globally acceptable approach for confirmation of theacceptability in the future.
Journal ArticleDOI
Swallowing difficulties with oral drugs among polypharmacy patients attending community pharmacies
Julien Marquis,Marie Paule Schneider,Valérie Payot,Anne-Christine Cordonier,Olivier Bugnon,Kurt E. Hersberger,Isabelle Arnet +6 more
TL;DR: A fairly high prevalence of swallowing difficulties in polypharmacy patients attending their community pharmacies is reported, with intentional non adherence and altering the oral dose formulation were the most common and potentially harmful strategies used by patients to overcome their swallowing difficulties.